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Volumn 48, Issue 35, 2009, Pages 8366-8378

Novel regulation of Smad3 oligomerization and DNA binding by its linker domain

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; BONE MORPHOGENETIC PROTEINS; DNA BINDING; HETERO-OLIGOMERIZATION; IN-LINE; LINKER REGION; MAMMALIAN CELLS; NUCLEAR ACCUMULATION; PHOSPHORYLATION SITES; SIGNALING PATHWAYS; TRANSACTIVATION; TRANSCRIPTIONALLY ACTIVE; TRANSFORMING GROWTH FACTORS; UBIQUITIN LIGASES; WILD TYPES;

EID: 69749123315     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9005489     Document Type: Article
Times cited : (12)

References (47)
  • 1
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague, J. (1998) TGF-beta signal transduction. Annu. Rev. Biochem. 67, 753-791.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massague, J.1
  • 2
    • 0026445528 scopus 로고
    • Transforming growth factor-beta: Recent progress and new challenges
    • Sporn, M. B., and Roberts, A. B. (1992) Transforming growth factor-beta: recent progress and new challenges. J. Cell Biol. 119, 1017-1021.
    • (1992) J. Cell Biol. , vol.119 , pp. 1017-1021
    • Sporn, M.B.1    Roberts, A.B.2
  • 3
    • 33646562542 scopus 로고    scopus 로고
    • The logic of TGFbeta signaling
    • Massague, J., and Gomis, R. R. (2006) The logic of TGFbeta signaling. FEBS letters 580, 2811-2820.
    • (2006) FEBS Letters , vol.580 , pp. 2811-2820
    • Massague, J.1    Gomis, R.R.2
  • 4
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel, P. M., and Massague, J. (2003) Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nature Rev. 3, 807-821.
    • (2003) Nature Rev. , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 5
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi, Y., and Massague, J. (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113, 685-700. (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 7
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • Massague, J., Seoane, J., and Wotton, D. (2005) Smad transcription factors. Genes Dev. 19, 2783-2810.
    • (2005) Genes Dev. , vol.19 , pp. 2783-2810
    • Massague, J.1    Seoane, J.2    Wotton, D.3
  • 8
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling
    • DOI 10.1016/S0092-8674(00)81600-1
    • Shi, Y., Wang, Y. F., Jayaraman, L., Yang, H., Massague, J., and Pavletich, N. P. (1998) Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell 94, 585-594. (Pubitemid 28427577)
    • (1998) Cell , vol.94 , Issue.5 , pp. 585-594
    • Shi, Y.1    Wang, Y.-F.2    Jayaraman, L.3    Yang, H.4    Massague, J.5    Pavletich, N.P.6
  • 9
    • 0035167095 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner
    • Kurisaki, A., Kose, S., Yoneda, Y., Heldin, C. H., and Moustakas, A. (2001) Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner. Mol. Biol. Cell 12, 1079-1091. (Pubitemid 33052000)
    • (2001) Molecular Biology of the Cell , vol.12 , Issue.4 , pp. 1079-1091
    • Kurisaki, A.1    Kose, S.2    Yoneda, Y.3    Heldin, C.-H.4    Moustakas, A.5
  • 10
    • 0030837455 scopus 로고    scopus 로고
    • A structural basis for mutational inactivation of the tumour suppressor Smad4
    • DOI 10.1038/40431
    • Shi, Y., Hata, A., Lo, R. S., Massague, J., and Pavletich, N. P. (1997) A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388, 87-93. (Pubitemid 27283894)
    • (1997) Nature , vol.388 , Issue.6637 , pp. 87-93
    • Shi, Y.1    Hata, A.2    Lo, R.S.3    Massague, J.4    Pavletich, N.P.5
  • 11
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • Massague, J. (2008) TGFbeta in Cancer. Cell 134, 215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 12
    • 0344625381 scopus 로고    scopus 로고
    • TGF-beta signaling and cancer: Structural and functional consequences of mutations in Smads
    • Hata, A., Shi, Y., and Massague, J. (1998) TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads. Mol. Med. Today 4, 257-262.
    • (1998) Mol. Med. Today , vol.4 , pp. 257-262
    • Hata, A.1    Shi, Y.2    Massague, J.3
  • 13
    • 0347991862 scopus 로고    scopus 로고
    • Integration of Smad and MAPK pathways: A link and a linker revisited
    • Massague, J. (2003) Integration of Smad and MAPK pathways: a link and a linker revisited. Genes Dev. 17, 2993-2997.
    • (2003) Genes Dev. , vol.17 , pp. 2993-2997
    • Massague, J.1
  • 14
    • 0034023127 scopus 로고    scopus 로고
    • Role of Ras and Mapks in TGFbeta signaling. Cytokine Growth Factor
    • Mulder, K.M. (2000) Role of Ras and Mapks in TGFbeta signaling. Cytokine Growth Factor Rev. 11, 23-35.
    • (2000) Rev. , vol.11 , pp. 23-35
    • Mulder, K.M.1
  • 15
    • 0030773834 scopus 로고    scopus 로고
    • Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
    • DOI 10.1038/39348
    • Kretzschmar, M., Doody, J., and Massague, J. (1997) Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389, 618-622. (Pubitemid 27446181)
    • (1997) Nature , vol.389 , Issue.6651 , pp. 618-622
    • Kretzschmar, M.1    Doody, J.2    Massague, J.3
  • 16
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFfbeta/Smad signaling by oncogenic Ras
    • Kretzschmar, M., Doody, J., Timokhina, I., and Massague, J. (1999) Amechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev. 13, 804-816. (Pubitemid 29169840)
    • (1999) Genes and Development , vol.13 , Issue.7 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massague, J.4
  • 17
    • 30944436222 scopus 로고    scopus 로고
    • Smad3 phosphorylation by cyclin-dependent kinases
    • Liu, F. (2006) Smad3 phosphorylation by cyclin-dependent kinases. Cytokine Growth Factor Rev. 17, 9-17.
    • (2006) Cytokine Growth Factor Rev. , vol.17 , pp. 9-17
    • Liu, F.1
  • 18
    • 22844440952 scopus 로고    scopus 로고
    • Inhibition of Smad antiproliferative function by CDK phosphorylation
    • Liu, F., and Matsuura, I. (2005) Inhibition of Smad antiproliferative function by CDK phosphorylation. Cell Cycle 4, 63-66. (Pubitemid 41038929)
    • (2005) Cell Cycle , vol.4 , Issue.1 , pp. 63-66
    • Liu, F.1    Matsuura, I.2
  • 19
    • 0033780420 scopus 로고    scopus 로고
    • Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II
    • Wicks, S. J., Lui, S., Abdel-Wahab, N., Mason, R. M., and Chantry, A. (2000) Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol. and Cell. Biol. 20, 8103-8111.
    • (2000) Mol. and Cell. Biol. , vol.20 , pp. 8103-8111
    • Wicks, S.J.1    Lui, S.2    Abdel-Wahab, N.3    Mason, R.M.4    Chantry, A.5
  • 20
    • 14244251723 scopus 로고    scopus 로고
    • The Smad3 linker region contains a transcriptional activation domain
    • DOI 10.1042/BJ20041820
    • Wang, G., Long, J., Matsuura, I., He, D., and Liu, F. (2005) The Smad3 linker region contains a transcriptional activation domain. Biochem. J. 386, 29-34. (Pubitemid 40289221)
    • (2005) Biochemical Journal , vol.386 , Issue.1 , pp. 29-34
    • Wang, G.1    Long, J.2    Matsuura, I.3    He, D.4    Liu, F.5
  • 21
    • 21444453507 scopus 로고    scopus 로고
    • Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein
    • DOI 10.1093/nar/gki679
    • Prokova, V., Mavridou, S., Papakosta, P., and Kardassis, D. (2005) Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein. Nucleic Acids Res. 33, 3708-3721. (Pubitemid 41418540)
    • (2005) Nucleic Acids Research , vol.33 , Issue.12 , pp. 3708-3721
    • Prokova, V.1    Mavridou, S.2    Papakosta, P.3    Kardassis, D.4
  • 23
    • 34547183455 scopus 로고    scopus 로고
    • Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1, Smad5, and Smad6 - Modeling and analysis
    • Sangadala, S., Metpally, R. P., and Reddy, B. V. (2007) Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1, Smad5, and Smad6 - modeling and analysis. J. Biomol. Struct. Dyn. 25, 11-23.
    • (2007) J. Biomol. Struct. Dyn. , vol.25 , pp. 11-23
    • Sangadala, S.1    Metpally, R.P.2    Reddy, B.V.3
  • 25
    • 0024520745 scopus 로고
    • Site-directed mutagenesis by overlap extension using the polymerase chain reaction
    • DOI 10.1016/0378-1119(89)90358-2
    • Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77, 51-59. (Pubitemid 19125653)
    • (1989) Gene , vol.77 , Issue.1 , pp. 51-59
    • Ho, S.N.1    Hunt, H.D.2    Horton, R.M.3    Pullen, J.K.4    Pease, L.R.5
  • 27
    • 11244325724 scopus 로고    scopus 로고
    • Inhibition of p53-mediated transcriptional responses by mithramycin a
    • DOI 10.1038/sj.onc.1208141
    • Koutsodontis, G., and Kardassis, D. (2004) Inhibition of p53- mediated transcriptional responses by mithramycin A. Oncogene 23, 9190-9200. (Pubitemid 40069689)
    • (2004) Oncogene , vol.23 , Issue.57 , pp. 9190-9200
    • Koutsodontis, G.1    Kardassis, D.2
  • 28
    • 0033377867 scopus 로고    scopus 로고
    • TGF-beta type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek, E., Moustakas, A., Kurisaki, A., Heldin, C. H., and ten Dijke, P. (1999) TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J. Cell Sci. 112 (Pt 24), 4557-4568. (Pubitemid 30034805)
    • (1999) Journal of Cell Science , vol.112 , Issue.24 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Heldin, C.-H.4    Ten Dijke, P.5
  • 30
    • 35348854570 scopus 로고    scopus 로고
    • Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids
    • DOI 10.1021/bi700994m
    • Thymiakou, E., Zannis, V. I., and Kardassis, D. (2007) Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids. Biochemistry 46, 11473-11483. (Pubitemid 47585493)
    • (2007) Biochemistry , vol.46 , Issue.41 , pp. 11473-11483
    • Thymiakou, E.1    Zannis, V.I.2    Kardassis, D.3
  • 31
    • 24944439828 scopus 로고    scopus 로고
    • Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3
    • DOI 10.1021/bi050560g
    • Matsuura, I., Wang, G., He, D., and Liu, F. (2005) Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry 44, 12546-12553. (Pubitemid 41324345)
    • (2005) Biochemistry , vol.44 , Issue.37 , pp. 12546-12553
    • Matsuura, I.1    Wang, G.2    He, D.3    Liu, F.4
  • 32
    • 0033549789 scopus 로고    scopus 로고
    • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    • Zhu, H., Kavsak, P., Abdollah, S., Wrana, J. L., and Thomsen, G. H. (1999) A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400, 687-693. (Pubitemid 129516185)
    • (1999) Nature , vol.400 , Issue.6745 , pp. 687-693
    • Zhu, H.1    Kavsak, P.2    Abdollah, S.3    Wrana, J.L.4    Thomsen, G.H.5
  • 34
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • DOI 10.1093/emboj/17.11.3091
    • Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17, 3091-3100. (Pubitemid 28254381)
    • (1998) EMBO Journal , vol.17 , Issue.11 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    Dijke, P.T.4    Huet, S.5    Gauthier, J.-M.6
  • 35
    • 0032428684 scopus 로고    scopus 로고
    • SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
    • DOI 10.1016/S0092-8674(00)81701-8
    • Tsukazaki, T., Chiang, T. A., Davison, A. F., Attisano, L., and Wrana, J. L. (1998) SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 95, 779-791. (Pubitemid 29014458)
    • (1998) Cell , vol.95 , Issue.6 , pp. 779-791
    • Tsukazaki, T.1    Chiang, T.A.2    Davison, A.F.3    Attisano, L.4    Wrana, J.L.5
  • 36
    • 0036682952 scopus 로고    scopus 로고
    • Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control
    • Qin, B. Y., Lam, S. S., Correia, J. J., and Lin, K. (2002) Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. Genes Dev. 16, 1950-1963.
    • (2002) Genes Dev. , vol.16 , pp. 1950-1963
    • Qin, B.Y.1    Lam, S.S.2    Correia, J.J.3    Lin, K.4
  • 37
    • 0036682542 scopus 로고    scopus 로고
    • From mono- To oligo-Smads: The heart of the matter in TGF-beta signal transduction
    • DOI 10.1101/gad.1016802
    • Moustakas, A., and Heldin, C. H. (2002) From mono- to oligo- Smads: the heart of the matter in TGF-beta signal transduction. Genes Dev. 16, 1867-1871. (Pubitemid 34832916)
    • (2002) Genes and Development , vol.16 , Issue.15 , pp. 1867-1871
    • Moustakas, A.1    Heldin, C.-H.2
  • 38
    • 0030963943 scopus 로고    scopus 로고
    • DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells
    • de Winter, J. P., Roelen, B. A., ten Dijke, P., van der Burg, B., and van den Eijnden-van Raaij, A. J. (1997) DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells. Oncogene 14, 1891-1899.
    • (1997) Oncogene , vol.14 , pp. 1891-1899
    • De Winter, J.P.1    Roelen, B.A.2    Ten Dijke, P.3    Van Der Burg, B.4    Van Den Eijnden-van Raaij, A.J.5
  • 39
    • 0033515587 scopus 로고    scopus 로고
    • Cooperative binding of smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation
    • Stroschein, S. L., Wang, W., and Luo, K. (1999) Cooperative binding of Smad proteins to two adjacent DNA elements in the plasminogen activator inhibitor-1 promoter mediates transforming growth factor beta-induced smad-dependent transcriptional activation. J. Biol. Chem 274, 9431-9441. (Pubitemid 129517914)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.14 , pp. 9431-9441
    • Stroschein, S.L.1    Wang, W.2    Luo, K.3
  • 40
    • 0035947593 scopus 로고    scopus 로고
    • Filamin Associates with Smads and Regulates Transforming Growth Factor-beta Signaling
    • DOI 10.1074/jbc.M008422200
    • Sasaki, A., Masuda, Y., Ohta, Y., Ikeda, K., and Watanabe, K. (2001) Filamin associates with Smads and regulates transforming growth factor-beta signaling. J. Biol. Chem 276, 17871-17877. (Pubitemid 37411346)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.21 , pp. 17871-17877
    • Sasaki, A.1    Masuda, Y.2    Ohta, Y.3    Ikeda, K.4    Watanabe, K.5
  • 41
    • 1242293682 scopus 로고    scopus 로고
    • Identification and characterization of a human smad3 splicing variant lacking part of the linker region
    • DOI 10.1016/j.gene.2003.11.026
    • Kjellman, C., Honeth, G., Jarnum, S., Lindvall, M., Darabi, A., Nilsson, I., Edvardsen, K., Salford, L. G., and Widegren, B. (2004) Identification and characterization of a human smad3 splicing variant lacking part of the linker region. Gene 327, 141-152. (Pubitemid 38230110)
    • (2004) Gene , vol.327 , Issue.2 , pp. 141-152
    • Kjellman, C.1    Honeth, G.2    Jarnum, S.3    Lindvall, M.4    Darabi, A.5    Nilsson, I.6    Edvardsen, K.7    Salford, L.G.8    Widegren, B.9
  • 42
    • 0035116044 scopus 로고    scopus 로고
    • Structural insights on smad function in TGFbeta signaling
    • DOI 10.1002/1521-1878(200103)23:3<223::AID-BIES1032>3.0.CO;2-U
    • Shi, Y. (2001) Structural insights on Smad function in TGFbeta signaling. BioEssays 23, 223-232. (Pubitemid 32192141)
    • (2001) BioEssays , vol.23 , Issue.3 , pp. 223-232
    • Shi, Y.1
  • 43
    • 36849087360 scopus 로고    scopus 로고
    • Novel mutations in smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells
    • DOI 10.1021/bi701540u
    • Prokova, V., Mavridou, S., Papakosta, P., Petratos, K., and Kardassis, D. (2007) Novel mutations in Smad proteins that inhibit signaling by the transforming growth factor beta in mammalian cells. Biochemistry 46, 13775-13786. (Pubitemid 350223905)
    • (2007) Biochemistry , vol.46 , Issue.48 , pp. 13775-13786
    • Prokova, V.1    Mavridou, S.2    Papakosta, P.3    Petratos, K.4    Kardassis, D.5
  • 44
    • 1642332084 scopus 로고    scopus 로고
    • Integration of smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • DOI 10.1016/S0092-8674(04)00298-3, PII S0092867404002983
    • Seoane, J., Le, H. V., Shen, L., Anderson, S. A., and Massague, J. (2004) Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117, 211-223. (Pubitemid 38496241)
    • (2004) Cell , vol.117 , Issue.2 , pp. 211-223
    • Seoane, J.1    Le, H.-V.2    Shen, L.3    Anderson, S.A.4    Massague, J.5
  • 45
    • 0033573092 scopus 로고    scopus 로고
    • Crystal structure of a transcriptionally active smad4 fragment
    • DOI 10.1016/S0969-2126(00)88340-9
    • Qin, B., Lam, S. S., and Lin, K. (1999) Crystal structure of a transcriptionally active Smad4 fragment. Structure 7, 1493-1503. (Pubitemid 30007235)
    • (1999) Structure , vol.7 , Issue.12 , pp. 1493-1503
    • Qin, B.1    Lam, S.S.W.2    Lin, K.3
  • 46
    • 0027382805 scopus 로고
    • Transcriptional activation in yeast by the proline-rich activation domain of human CTF1
    • Kim, T. K., and Roeder, R. G. (1993) Transcriptional activation in yeast by the proline-rich activation domain of human CTF1. J. Biol. Chem 268, 20866-20869. (Pubitemid 23292263)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.28 , pp. 20866-20869
    • Kim, T.K.1    Roeder, R.G.2
  • 47
    • 0025865916 scopus 로고
    • Analysis of the DNA-binding and activation properties of the human transcription factor AP-2
    • Williams, T., and Tjian, R. (1991) Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev. 5, 670-682. (Pubitemid 21905986)
    • (1991) Genes and Development , vol.5 , Issue.4 , pp. 670-682
    • Williams, T.1    Tjian, R.2


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