Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways

Molecular Medicine

Volumn 7, Issue 12, 2001, Pages 816-830

  Bouzahzah, Boumediene ^a   Albanese, Chris ^a   Ahmed, Fayyaz ^a   Pixley, Fiona ^a   Lisanti, Michael P ^a   Segall, Jeffrey D ^a   Condeelis, John ^a   Joyce, David ^a   Minden, Audrey ^a   Der, Channing J ^a   Chan, Amanda ^a   Symons, Marc ^a   Pestell, Richard G ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGAR; GUANOSINE TRIPHOSPHATASE; PHOSPHOTYROSINE; PROTEIN CDC42; RAC PROTEIN; RHO FACTOR; VINCULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BREAST ADENOCARCINOMA; BREAST EPITHELIUM; BREAST TUMOR; CANCER GRAFT; CANCER SIZE; CARCINOGENESIS; CARCINOGENICITY; CELL CULTURE; CELL GROWTH; CELL LINE; CELL SPREADING; CELL STRAIN; CHEMOTAXIS; CONTROLLED STUDY; IN VIVO STUDY; LUNG METASTASIS; LUNG PARENCHYMA; METASTASIS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM;

EID: 0035715879     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401974     Document Type: Article

References (78)

1. Rho GTPases and signaling networks
2. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
3. Membrane ruffling and signal transduction
4. Rho family of proteins in cell adhesion and cell migration
5. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
6. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
7. Rho Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
8. Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility
9. ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility
10. A role for cdc42 in macrophage chemotaxis
11. Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways
12. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
13. Motility and invasion are differentially modulated by Rho family GTPases
14. Lamellipodia in invasion
15. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
16. Development and biologic properties of malignant cell sublines and clones of a spontaneously metastasizing rat mammary adenocarcinoma
17. Comparison of 'spontaneous' and 'experimental' metastasis using rat 13762 mammary adenocarcinoma metastatic cell clones
18. EGF receptor in neoplasia and metastasis
19. Heterogeneous response to the growth factors [EGF, PDGF (bb), TGF-alpha, bFGF, IL-2] on glioma spheroid growth, migration and invasion
20. EGF and TGF-alpha are potent chemoattractants for endothelial cells and EGF-like peptides are present at sites of tissue regeneration
21. Epidermal growth factor promotes the chemotactic migration of cultured rat intestinal epithelial cells
22. EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism
23. EGF stimulates actin nucleation at the tip of the lamellipod in mammary adenocarcinoma cells
24. Regulation of protrusion shape and adhesion to the substratum during chemotactic responses of mammalian carcinoma cells
25. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway
26. Epidermal growth factor induction of the c-jun promoter by a Rac pathway
27. 2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun
28. Rac regulation of transformation, gene expression and actin organisation by multiple, PAK-independent pathways
29. Caveolin-1 inhibits EGF-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenoviral-mediated gene delivery of caveolin-1
30. p300 and P/CAF acetylate the androgen receptor at sites governing hormone-dependent transactivation
31. Transforming growth factor β1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo
32. ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
33. Angiotensin II (AII) activation of cyclin D1-dependent kinase activity
34. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and activate the p42/p44 MAP kinase cascade
35. A critical step in metastasis: In vivo analysis of intravasation at the primary tumor
36. Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly
37. The molecular architecture of focal adhesions
38. Molecular interactions in cell adhesion complexes
39. Integrin transmembrane signaling and cytoskeletal control
40. Molecular diversity of cell-matrix adhesions
41. Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions
42. Cell locomotion and focal adhesions are regulated by substrate flexibility
43. Assembly of focal adhesions: Progress, paradigms, and portents
44. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
45. Involvement of microtubules in the control of adhesion-dependent signal transduction
46. EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLC (gamma) signaling pathway
47. A role for Rho in Ras transformation
48. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation
49. Integrin-mediated signals regulated by members of the Rho family of GTPases
50. Ligand mediated activation of ectopic EGF receptor promotes matrix protein adhesion and lung colonization of rat mammary adenocarcinoma cells
51. Induction of apoptosis by EGF receptor in rat mammary adenocarcinoma cells coincides with enhanced spontaneous tumour metastasis
52. GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more
53. Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior
54. Rho family GTPases and neuronal growth cone remodeling: Relationship between increased complexity induced by Cdc42Hs, Rac1 and acetylcholine and collapse induced by RhoA and lysophosphatidic acid
55. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
56. Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization
57. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by ras
58. Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer
59. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
60. Focal adhesion assembly
61. Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions
62. Effects of protein-kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system
63. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function
64. Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes
65. Signaling to Rho GTPases
66. Integrin alphav-beta3 mediates chemotactic and haptotactic motility in human melanoma cells through different signaling pathways
67. Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity
68. Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation
69. Integrin and cytoskeletal regulation of growth factor signaling to the MAP kinase pathway
70. Differential effect of rac and cdc42 on p38 kinase activity and cell cycle progression of nonadherent primary mouse fibroblasts
71. An essential role for Rac in Ras transformation
72. 1
73. Rac1 protects epithelial cells against anoikis
74. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
75. Integration of Rac-dependent regulation of cyclin D1 transcription through an NF-κB-dependent pathway
76. Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change
77. Ligand-induced activation of epidermal growth factor receptor in intact rat mammary adenocarcinoma cells without detectable receptor phosphorylation
78. Genomic analysis of metastasis reveals an essential role for RhoC