eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration

Oncogene

Volumn 26, Issue 21, 2007, Pages 3027-3040

  Amiri, A ^a   Noei, F ^a   Jeganathan, S ^a   Kulkarni, G ^a   Pinke, D E ^a   Lee, J M ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Actin; Akt; Cell motility; eEF1A2; Filopodia; Protein translation

Indexed keywords

ACTIN; ELONGATION FACTOR 1ALPHA; EUKARYOTIC PROTEIN ELONGATION FACTOR 1ALPHA 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; ROCK KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVATION; ENZYME ACTIVITY; FETUS; FILOPODIUM; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RNA INTERFERENCE;

ACTINS; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CYTOSKELETON; ENZYME ACTIVATION; FEMALE; HUMANS; ISOENZYMES; NEOPLASM INVASIVENESS; PEPTIDE ELONGATION FACTOR 1; PROTO-ONCOGENE PROTEINS C-AKT; RATS;

EUKARYOTA; MAMMALIA;

EID: 34248340402     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210101     Document Type: Article

References (50)

1. Adams AT, Auersperg N. (1985). A cell line, ROSE 199, derived from normal rat ovarian surface epithelium. Exp Cell Biol 53: 181-188.
2. Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH et al. (2002). Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nat Genet 31: 301-305.
3. Arboleda MJ, Lyons JF, Kabbinavar FF, Bray MR, Snow BE, Ayala R et al. (2003). Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res 63: 196-206.
4. Carpenter CL, Cantley LC. (1990). Phosphoinositide kinases. Biochemistry 29: 11147-11156.
5. Carragher NO, Frame MC. (2004). Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol 14: 241-249.
6. Chang R, Wang E. (2006). Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress. J Cell Biochem, epub ahead of print.
7. Chen J, Deangelo DJ, Kutok JL, Williams IR, Lee BH, Wadleigh M et al. (2004). Regulation of anoikis by Cdc42 and Rac1. Proc Natl Acad Sci USA 101: 14479-14484.
8. Chodniewicz D, Klemke RL. (2004). Guiding cell migration through directed extension and stabilization of pseudopodia. Exp Cell Res 301: 31-37.
9. Condeelis J. (1995). Elongation factor 1 alpha, translation and the cytoskeleton. Trends Biochem Sci 20: 169-170.
10. Crews CM, Collins JL, Lane WS, Snapper ML, Schreiber SL. (1994). GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha. J Biol Chem 269: 15411-15414.
11. Edmonds BT, Wyckoff J, Yeung YG, Wang Y, Stanley ER, Jones J et al. (1996). Elongation factor-1 alpha is an overexpressed actin binding protein in metastatic rat mammary adenocarcinoma. J Cell Sci 109(Part 11): 2705-2714.
12. Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K et al. (2005). Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev Cell 9: 389-402.
13. Fitzsimmons SA, Ireland H, Barr NI, Cuthbert AP, Going JJ, Newbold RF et al. (2003). Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15. Oncogene 22: 1737-1746.
14. Fruman DA, Meyers RE, Cantley LC. (1998). Phosphoinositide kinases. Annu Rev Biochem 67: 481-507.
15. Gross SR, Kinzy TG. (2005). Translation elongation factor 1A is essential for regulation of the actin cytoskeleton and cell morphology. Nat Struct Mol Biol 12: 772-778.
16. Heilmeyer Jr LM, Vereb Jr G, Vereb G, Kakuk A, Szivak I. (2003). Mammalian phosphatidylinositol 4-kinases. IUBMB Life 55: 59-65.
17. Hershey JW. (1991). Translational control in mammalian cells. Annu Rev Biochem 60: 717-755.
18. Jimeno J, Lopez-Martin JA, Ruiz-Casado A, Izquierdo MA, Scheuer PJ, Rinehart K. (2004). Progress in the clinical development of new marine-derived anticancer compounds. Anticancer Drugs 15: 321-329.
19. Kahns S, Lund A, Kristensen P, Knudsen CR, Clark BF, Cavallius J et al. (1998). The elongation factor 1 A-2 isoform from rabbit: cloning of the cDNA and characterization of the protein. Nucleic Acids Res 26: 1884-1890.
20. Knudsen SM, Frydenberg J, Clark BF, Leffers H. (1993). Tissue-dependent variation in the expression of elongation factor-1 alpha isoforms: isolation and characterisation of a cDNA encoding a novel variant of human elongation-factor 1 alpha. Eur J Biochem 215: 549-554.
21. Kulkarni G, Turbin DA, Amiri A, Jeganathan S, Andrade-Navarro MA, Wu TD et al. (2006). Expression of protein elongation factor eEF1A2 predicts favorable outcome in breast cancer. Breast Cancer Res Treat (e-pub ahead of print).
22. Kumar R, Gururaj AE, Barnes CJ. (2006). p21-activated kinases in cancer. Nat Rev Cancer 6: 459-471.
23. Lau J, Castelli LA, Lin EC, Macaulay SL. (2006). Identification of elongation factor 1alpha as a potential associated binding partner for Akt2. Mol Cell Biochem 286: 17-22.
24. Lee JM. (2003). The role of protein elongation factor eEF1A2 in ovarian cancer. Reprod Biol Endocrinol 1: 69.
25. Lee S, Wolfraim LA, Wang E. (1993). Differential expression of S1 and elongation factor-1 alpha during rat development. J Biol Chem 268: 24453-24459.
26. Li R, Wang H, Bekele BN, Yin Z, Caraway NP, Katz RL et al. (2005). Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach. Oncogene 25: 2628-2635.
27. Meijer HJ, Munnik T. (2003). Phospholipid-based signaling in plants. Annu Rev Plant Rev 54: 265-306.
28. Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero CP, Sterner CJ et al. (2005). The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8: 197-209.
29. Munshi R, Kandl KA, Carr-Schmid A, Whitacre JL, Adams AE, Kinzy TG. (2001). Overexpression of translation elongation factor 1A affects the organization and function of the actin cytoskeleton in yeast. Genetics 157: 1425-1436.
30. Nathrath MH, Kuosaite V, Rosemann M, Kremer M, Poremba C, Wakana S et al. (2002). Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man. Oncogene 21: 5975-5980.
31. Overduin M, Cheever ML, Kutateladze TG. (2001). Signaling with phosphoinositides: better than binary. Mol Interv 1: 150-159.
32. Owen CH, DeRosier DJ, Condeelis J. (1992). Actin crosslinking protein EF-1a of Dictyostelium discoideum has a unique bonding rule that allows square-packed bundles. J Struct Biol 109: 248-254.
33. Pencil SD, Toh Y, Nicolson GL. (1993). Candidate metastasisassociated genes of the rat 13762NF mammary adenocarcinoma. Breast Cancer Res Treat 25: 165-174.
34. Pendaries C, Tronchere H, Arbibe L, Mounier J, Gozani O, Cantley L et al. (2006). PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. EMBO J 25: 1024-1034.
35. Qian Y, Corum L, Meng Q, Blenis J, Zheng JZ, Shi X et al. (2004). PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. Am J Physiol Cell Physiol 286: C153-63.
36. Reinhard M, Halbrugge M, Scheer U, Wiegand C, Jockusch BM, Walter U. (1992). The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts. EMBO J 11: 2063-2070.
37. Riento K, Ridley AJ. (2003). Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol 4: 446-456.
38. Rodrigues SP, Fathers KE, Chan G, Zuo D, Halwani F, Meterissian S et al. (2005). CrkI and CrkII function as key signaling integrators for migration and invasion of cancer cells. Mol Cancer Res 3: 183-194.
39. Svitkina TM, Bulanova EA, Chaga OY, Vignjevic DM, Kojima S, Vasiliev JM et al. (2003). Mechanism of filopodia initiation by reorganization of a dendritic network. J Cell Biol 160: 409-421.
40. Thornton S, Anand N, Purcell D, Lee J. (2003). Not just for housekeeping: protein initiation and elongation factors in cell growth and tumorigenesis. J Mol Med 81: 536-548.
41. Tomlinson VA, Newbery HJ, Wray NR, Jackson J, Larionov A, Miller WR et al. (2005). Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours. BMC Cancer 5: 113.
42. Tornieri K, Welshhans K, Geddis MS, Rehder V. (2006). Control of neurite outgrowth and growth cone motility by phosphatidylinositol-3-kinase. Cell Motil Cytoskeleton 63: 173-192.
43. Verhagen PC, Hermans KG, Brok MO, van Weerden WM, Tilanus MG, de Weger RA et al. (2002). Deletion of chromosomal region 6q14-16 in prostate cancer. Int J Cancer 102: 142-147.
44. Vivanco I, Sawyers CL. (2002). The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501.
45. Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S et al. (2004). Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Science 304: 1164-1166.
46. Yamaguchi H, Wyckoff J, Condeelis J. (2005). Cell migration in tumors. Curr Opin Cell Biol 17: 559-564.
47. Yang F, Demma M, Warren V, Dharmawardhane S, Condeelis J. (1990). Identification of an actin-binding protein from Dictyostelium as elongation factor 1. Nature 347: 494-496.
48. Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI et al. (2004). Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 64: 4394-4399.
49. Yang W, Burkhart W, Cavallius J, Merrick WC, Boss WF. (1993). Purification and characterization of a phosphatidylinositol 4-kinase activator in carrot cells. J Biol Chem 268: 392-398.
50. Zhou GL, Zhuo Y, King CC, Fryer BH, Bokoch GM, Field J. (2003). Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration. Mol Cell Biol 23: 8058-8069.