Memo - RhoA - mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells

Journal of Cell Biology

Volumn 183, Issue 3, 2008, Pages 401-408

  Zaoui, Kossay ^a,b,c   Honoré, Stéphane ^c,d   Isnardon, Daniel ^a,b,c   Braguer, Diane ^c,d   Badache, Ali ^a,b,c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSTITUT PAOLI CALMETTES   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d University of the Mediterranean Aix Marseille II   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ; EPIDERMAL GROWTH FACTOR RECEPTOR 2; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ACTIN; DIAPH1 PROTEIN, HUMAN; MEMO PROTEIN, HUMAN; NONHEME IRON PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ACTIN FILAMENT; ARTICLE; BREAST CARCINOMA; CELL ADHESION; CELL CYCLE REGULATION; CELL GROWTH; CELL MIGRATION; CELL MOTILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LAMELLIPODIUM; MICROTUBULE ASSEMBLY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS REGULATION; BREAST TUMOR; CELL MEMBRANE; CELL MOTION; CYTOSOL; GENETICS; MICROTUBULE; PHYSIOLOGY; PSEUDOPODIUM; TUMOR CELL LINE;

ACTINS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; CYTOSOL; HUMANS; MICROTUBULES; NONHEME IRON PROTEINS; PSEUDOPODIA; RHOA GTP-BINDING PROTEIN;

EID: 56149118852     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200805107     Document Type: Article

References (24)

1. Bear , J.E., T.M. Svitkina, M. Krause, D.A. Schafer , J.J. Loureiro, G.A. Strasser , I.V. Maly, O.Y. Chaga, J.A. Cooper, G.G. Borisy, and F.B. Gertler . 2002. Antagonism between Ena/VASP proteins and actin f lament capping regulates f broblast motility. Cell. 109:509-521.
2. Burridge, K., and K. Wennerberg. 2004. Rho and Rac take center stage. Cell. 116:167-179.
3. Cho, S.Y., and R.L. Klemke. 2002. Purif cation of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J. Cell Biol. 156:725-736.
4. Giannone, G., B.J. Dubin-Thaler, O. Rossier, Y. Cai , O. Chaga , G. Jiang, W. Beaver , H.G. Dobereiner , Y. Freund, G. Borisy , and M.P. Sheetz. 2007. Lamellipodial actin mechanically links myosin activity with adhesionsite formation. Cell. 128:561-575.
5. Ishizaki, T., Y. Morishima, M. Okamoto, T. Furuyashiki, T. Kato, and S. Narumiya . 2001 . Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1. Nat. Cell Biol. 3:8-14.
6. Kaverina, I., O. Krylyshkina, and J.V. Small. 1999. Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J. Cell Biol. 146:1033-1044.
7. Kovar, D.R., E.S. Harris, R. Mahaffy, H.N. Higgs, and T.D. Pollard. 2006. Control of the assembly of ATP- and ADP-actin by formins and prof lin. Cell. 124:423-435.
8. Kurokawa, K., and M. Matsuda. 2005. Localized RhoA activation as a requirement for the induction of membrane ruffing. Mol. Biol. Cell. 16:4294-4303.
9. Lauffenburger , D.A. , and A.F. Horwitz . 1996 . Cell migration: a physically integrated molecular process. Cell. 84:359-369.
10. Marone, R., D. Hess, D. Dankort, W.J. Muller , N.E. Hynes , and A. Badache . 2004 . Memo mediates ErbB2-driven cell motility. Nat. Cell Biol. 6:515-522.
11. Michaelson, D., J. Silletti, G. Murphy, P. D'Eustachio, M. Rush, and M.R. Philips . 2001 . Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding. J. Cell Biol. 152:111-126.
12. Mitchison, T., and M. Kirschner. 1984. Dynamic instability of microtubule growth. Nature. 312:237-242.
13. Otey, C.A. , and O. Carpen . 2004 . Alpha-actinin revisited: a fresh look at an old player. Cell Motil. Cytoskeleton. 58:104-111.
14. Palazzo, A.F., T.A. Cook, A.S. Alberts, and G.G. Gundersen. 2001. mDia mediates Rho-regulated formation and orientation of stable microtubules. Nat. Cell Biol. 3:723-729.
15. Pertz, O., L. Hodgson, R.L. Klemke, and K.M. Hahn. 2006. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature. 440:1069-1072.
16. Pollard, T.D., and G.G. Borisy . 2003 . Cellular motility driven by assembly and disassembly of actin flaments. Cell. 112:453-465.
17. Ponti, A., M. Machacek, S.L. Gupton, C.M. Waterman-Storer, and G. Danuser. 2004 . Two distinct actin networks drive the protrusion of migrating cells. Science. 305:1782-1786.
18. Pourroy, B., S. Honore, E. Pasquier, V. Bourgarel-Rey , A. Kruczynski, C. Briand, and D. Braguer. 2006. Antiangiogenic concentrations of vinf unine increase the interphase microtubule dynamics and decrease the motility of endothelial cellsiCancer Res. 66:3256-3263.
19. Ridley, A.J., M.A. Schwartz, K. Burridge, R.A. Firtel, M.H. Ginsberg, G. Borisy , J.T. Parsons, and A.R. Horwitz. 2003. Cell migration: integrating signals from front to back. Science. 302:1704-1709.
20. Rodriguez, O.C., A.W. Schaefer , C.A. Mandato, P. Forscher , W.M. Bement, and C.M. Waterman-Storer. 2003. Conserved microtubule-actin interactions in cell movement and morphogenesis. Nat. Cell Biol. 5:599-609.
21. Totsukawa, G.,Y. Wu,Y. Sasaki, D.J. Hartshorne,Y.Yamakita, S.Yamashiro, and F. Matsumura . 2004 . Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fbroblasts. J. Cell Biol. 164:427-439.
22. Watanabe, N., P. Madaule, T. Reid, T. Ishizaki, G. Watanabe, A. Kakizuka, Y. Saito, K. Nakao, B.M. Jockusch, and S. Narumiya. 1997. p140mDia, a mammalian homolog of Drosophila diaphanous , is a target protein for Rho small GTPase and is a ligand for proflin. EMBO J. 16:3044-3056.
23. Wen, Y., C.H. Eng, J. Schmoranzer, N. Cabrera-Poch, E.J. Morris, M. Chen, B.J. Wallar, A.S. Alberts, and G.G. Gundersen. 2004. EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration. Nat. Cell Biol. 6:820-830.
24. Yang, C., L. Czech, S. Gerboth, S. Kojima, G. Scita, and T. Svitkina. 2007. Novel roles of formin mDia2 in lamellipodia and f lopodia formation in motile cells. PLoS Biol. 5:e317.