Potentiation of the analgesic properties of fentanyl-like opioids with alpha 2-adrenoceptor agonists in rats
Meert TF, De Kock M. Potentiation of the analgesic properties of fentanyl-like opioids with alpha 2-adrenoceptor agonists in rats. Anesthesiology 1994; 81: 677-688.
Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury
Ossipov MH et al. Synergistic antinociceptive interactions of morphine and clonidine in rats with nerve-ligation injury. Anesthesiology 1997; 86: 196-204.
The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy
Stone LS et al. The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 1997; 17: 7157-7165.
Alpha 2-adrenoceptor agonists and stress-induced analgesia in rats: Influence of stressors and methods of analysis
De Kock M, Meert TF. Alpha 2-adrenoceptor agonists and stress-induced analgesia in rats: influence of stressors and methods of analysis. Pharmacol Biochem Behav 1997; 58: 109-117.
Spinal morphine/clonidine antinociceptive synergism is regulated by protein kinase C, but not protein kinase A activity
Wei ZY, Roerig SC. Spinal morphine/clonidine antinociceptive synergism is regulated by protein kinase C, but not protein kinase A activity. J Pharmacol Exp Ther 1998; 287: 937-943.
Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knock out mice brain
Höcker J et al. Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knock out mice brain. Eur J Pharmacol 2008; 582: 70-77.
Yohimbine-induced alterations in alpha(2)-adrenoceptors in kidney regions of the spontaneously hypertensive rats: An autoradiographic analysis
Saiz J et al. Yohimbine-induced alterations in alpha(2)-adrenoceptors in kidney regions of the spontaneously hypertensive rats: an autoradiographic analysis. Pharmacol Rep 200; 60: 391-398.
Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
Hunter JC et al. Assessment of the role of alpha2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 1997; 122: 1339-1344.
Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
Lakhlani PP et al. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci U S A 1997; 94: 9950-9955.
Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors
Sawamura S et al. Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors. J Neurosci 2000; 20: 9242-9251.
Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice
Bucheler MM et al. Two alpha(2)-adrenergic receptor subtypes, alpha(2A) and alpha(2C), inhibit transmitter release in the brain of gene-targeted mice. Neuroscience 2002; 109: 819-826.
Regional distribution of alpha(2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the alpha(2C)-subtype: An autoradiographic study with [(3)H]RX821002 and [(3)H] rauwolscine
Holmberg M et al. Regional distribution of alpha(2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the alpha(2C)-subtype: an autoradiographic study with [(3)H]RX821002 and [(3)H] rauwolscine. Neuroscience 2003; 117: 875-898.
alpha 2-Adrenergic receptors in human spinal cord: Specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels
Smith MS et al. alpha 2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels. Brain Res Mol Brain Res 1995; 34: 109-117.
Characterization and autoradiographical localization of non-adrenoceptor idazoxan binding sites in the rat brain
Mallard NJ et al. Characterization and autoradiographical localization of non-adrenoceptor idazoxan binding sites in the rat brain. Br J Pharmacol 1992; 106: 1019-1027.
Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system
Rosin DL et al. Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. J Comp Neurol 1996; 372: 135-165.
Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: Evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals
Wang R et al. Expression of alpha 2-adrenergic receptor subtypes in the mouse brain: evaluation of spatial and temporal information imparted by 3 kb of 5' regulatory sequence for the alpha 2A AR-receptor gene in transgenic animals. Neuroscience 1996; 74: 199-218.
The analgesic efficacy of partial opioid agonists is increased in mice with targeted inactivation of the alpha2A-adrenoceptor gene
Ozdogan UK et al. The analgesic efficacy of partial opioid agonists is increased in mice with targeted inactivation of the alpha2A-adrenoceptor gene. Eur J Pharmacol 2006; 529: 105-113.
The alpha2A-adrenoceptor subtype is not involved in inflammatory hyperalgesia or morphine-induced antinociception
Lähdesmäki J et al. The alpha2A-adrenoceptor subtype is not involved in inflammatory hyperalgesia or morphine-induced antinociception. Eur J Pharmacol 2003; 468: 183-189.
Fluorescence resonance energy transfer analysis of {alpha}2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes
Zurn A et al. Fluorescence resonance energy transfer analysis of {alpha}2a-adrenergic receptor activation reveals distinct agonist-specific conformational changes. Mol Pharmacol 2009; 75: 534-541.
