α2-Adrenoceptor agonists and stress-induced analgesia in rats: Influence of stressors and methods of analysis

Pharmacology Biochemistry and Behavior

Volumn 58, Issue 1, 1997, Pages 109-117

  De Kock, Marc ^a   Meert, Theo F ^b  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

2 Adrenoceptor agonist; Benzodiazepine; Data analysis; Opioid; Stress; Tail withdrawal reaction test

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BENZODIAZEPINE DERIVATIVE; CHLORDIAZEPOXIDE; CLONIDINE; DEXMEDETOMIDINE; FENTANYL; NALOXONE; OPIATE; XYLAZINE;

ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; DRUG SCREENING; IMMOBILIZATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION; WITHDRAWAL REFLEX;

ADRENERGIC ALPHA-AGONISTS; ANALGESIA; ANALGESICS, OPIOID; ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; BENZODIAZEPINES; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HANDLING (PSYCHOLOGY); HOUSING, ANIMAL; IMIDAZOLES; IMMOBILIZATION; MALE; MEDETOMIDINE; NARCOTIC ANTAGONISTS; PAIN MEASUREMENT; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-2; STRESS, PSYCHOLOGICAL; XYLAZINE;

ANIMALIA;

EID: 0030762732     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00462-5     Document Type: Article

References (36)

1. Bernard J. M., Hommeril J. L., Passuti N., Pinaud M. Postoperative analgesia by intravenous clonidine. Anesthesiology. 75:1991;577-582.
2. Bodnar R. J., Merrigan K. P., Sperber E. Potentiation of cold-water swim analgesia and hypothermia by clonidine. Pharmcol. Biochem. Behav. 19:1983;447-451.
3. Browning S., Lawrence D., Livingston A., Morris B. Interactions of drugs active at opiate receptors and drugs active at alpha2-receptors on various test systems. Br. J. Pharmacol. 77:1982;487-491.
4. Chance W. T., Schechter M.D. Autoanalgesia. Blockade by yohimbine Eur. J. Pharmacol. 58:1979;89-90.
5. De Kock, M.; Meert, T. F.: Can alpha2-adrenoceptor agonists reverse or prevent tolerance to the antinociceptive activity of opioids in rats? Acta Anaesthesiol. Belg.; 1996, in press.
6. De Kock M., Pichon G., Scholtes J. L. Intraoperative clonidine enhances postoperative morphine patient-controlled analgesia. Can. J. Anaesth. 39:1992;537-544.
7. Dennis S. G., Melzack R., Gutman S., Boucher F. Pain modulation by adrenergic agents and morphine as measured by three pain tests. Life Sci. 26:1980;1247-1259.
8. Edwarts M., Serrao J. M., Gent J. P., Goodchild C. S., Chir B. On the mechanism by which midazolam causes spinally mediated analgesia. Anesthesiology. 73:1990;273-277.
9. Hayes R., Katayama Y. Range of environmental stimuli producing nociceptive suppression. Implications for neural mechanisms Ann. N.Y. Acad. Sci. 467:1986;1-13.
10. Horvath G., Kovaks M., Szikaszay M., Benedek G Mydriatic and antinociceptive effects of intrathecal dexmedetomidine in conscious rats. Eur. J. Pharmacol. 253:1994;61-66.
11. Janssen P. A. J., Niemegeers C., Dony J. The inhibitory effects of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawal reflex in rats. Arzneimittelforschung. 13:1963;502-507.
12. Kissin I., Brown P. T., Bradley E. L., Robinson C.A., Cassady J. L. Diazepam-morphine hypnotic synergism in rats. Anesthesiology. 70:1989;689-694.
13. Konarska M., Stewart R. E., McCarty R. Habituation of sympathic-adrenal medullary responses following exposure to chronic intermittent stress. Physiol. Behav. 45:1989;255-261.
14. Langer S. Z. Presynaptic regulation of catecholamine release. Biochem. Pharmacol. 23:1974;1793-1800.
15. Lewis J. W. Multiple neurochemical and hormonal mechanisms of stress induced analgesia. Ann. N.Y. Acad. Sci. 467:1986;194-204.
16. Malmberg M., Yaksh T. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. Anesthesiology. 79:1993;270-281.
17. 2-adrenoceptors of the medullary lateral reticular nucleus in spinal antinociception in rats. Brain Res. Bull. 37:1995;633-638.
18. Meert T. F., De Kock M. Interactions between the lipophilic opioid sufentanil and clonidine in rats after spinal application. Acta Anaesthesiol. Scand. 39:1995;528-535.
19. 2-adrenoceptor agonists in rats. Anesthesiology. 81:1994;677-688.
20. Monasky M. S., Zinsmeister A. R., Stevens C. W., Yaksh T. L. Interaction of intrathecal morphine and ST-91 on antinociception in the rat. Dose-response analysis, antagonism and clearance J. Pharmacol. Exp. Ther. 254:1990;383-392.
21. Morrow J., Casey K. L. Modulation of the spontaneous and evoked discharges of ventral posterior thalamic neurons during shifts in arousal. Brain Res. Bull. 21:1989;433-435.
22. 2-Adrenoceptor involvement in swim stress-induced antinociception in the mouse. J. Pharm. Pharmacol. 42:1990;778-784.
23. Ossipov M. H., Harris S., Lloyd P., Messineo E., Lin B. S., Bagley L. Antinociceptive interaction between opioids and medetomidine. Systemic additivity and spinal synergy Anesthesiology. 73:1990;1227-1235.
24. 2-adrenoceptor agonist, in various pain tests. Eur. J. Pharmacol. 179:1990;323-328.
25. Reves J. G., Glass P. S. A., Lubarsky D. Nonbarbiturate intravenous anesthetics. Miller R. D. Anesthesia. 4:1994;255-256 Churchill Livingstone, New York.
26. Saeki S., Yaksh T. L. Suppression by spinal alpha2-agonists of motor and autonomic responses evoked by low and high intensity thermal stimuli. J. Pharmacol. Exp. Ther. 260:1992;795-802.
27. 2-adrenergic agonists and benzodiazepines in rats. Anesthesiology. 76:1992;1004-1011.
28. Siegel S. Nonparametric statistics for the behavioral sciences. 1956;McGraw-Hill Book Co, New York.
29. Snow A. E., Tucker S. M., Dewey W. L. The role of neurotransmitters in stress-induced antinociception (SIA). Pharmacol. Biochem. Behav. 16:1982;47-50.
30. Spaulding T. C., Venafro J. J., Ma M. G., Fielding S. The dissociation of the antinociceptive effect of clonidine from supraspinal structures. Neuropharmacology. 18:1979;103-105.
31. Stevens C. G., Monasky M. S., Yaksh T. L. Spinal infusion of opiates and alpha-2 agonists in rats. Tolerance and cross tolerance studies J. Pharmacol. Exp. Ther. 244:1988;63-70.
32. Veith R. C., Best J. D., Halter J. B. Dose-dependent suppression of norepinephrine appearance rate in plasma by clonidine in man. J. Clin. Endocrinol. Metab. 59:1984;151-155.
33. Vercauteren M., Lauwers E., Meert T., De Hert S., Adriaenssen H. Comparison of epidural sufentanil plus clonidine with sufentanil for postoperative pain relief. Anaesthesia. 45:1990;531-534.
34. Vinik H. R., Bradley E. L., Kissin I. Midazolam-alfentanil synergism for anesthetic induction in patients. Anesth. Analg. 69:1989;213-217.
35. Vonvoightlander P. F. Pharmacological alteration of pain. The discovery and evaluation of analgesic in animals, chemistry and pharmacology of drugs Lednicer A. J. Central analgesics, vol. 1. 1982;51-80 Wiley, New York.
36. Yaksh, T. L.; Malmberg, A. B.: Central pharmacology of nociceptive transmission. In: Wall, P. D.; Melzack, R., eds. Textbook of pain, 3rd ed. Edinburg: Churchill Livingstone; 1994:165-200.