Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-κB activation and invasive prostate carcinoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 31, 2009, Pages 12962-12967

  Fernandez Marcos, Pablo J ^a   Abu Baker, Shadi ^b   Joshi, Jayashree ^b   Galvez, Anita ^b   Castilla, Elias A ^b   Cañamero, Marta ^a   Collado, Manuel ^a   Saez, Carmen ^c   Moreno Bueno, Gema ^a   Palacios, Jose ^c   Leitges, Michael ^d   Serrano, Manuel ^a   Moscat, Jorge ^b   Diaz Meco, Maria T ^b  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

AKT; aPKC; IL 6; Inflammation; Prostate cancer

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEINASE ACTIVATED RECEPTOR 4; APOPTOSIS REGULATORY PROTEIN; PROSTATE APOPTOSIS RESPONSE 4 PROTEIN; PROSTATE APOPTOSIS RESPONSE-4 PROTEIN; PROTEIN KINASE C; PROTEIN KINASE C ZETA; PTEN PROTEIN, HUMAN; PTEN PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CARCINOGENESIS; CHROMOSOME 10; CONTROLLED STUDY; HETEROZYGOSITY; IN VIVO STUDY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; ADENOCARCINOMA; ANIMAL; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR;

MUS;

ADENOCARCINOMA; ANIMALS; APOPTOSIS REGULATORY PROTEINS; HUMANS; MALE; MICE; MUTATION; NEOPLASM INVASIVENESS; NF-KAPPA B; PROSTATIC NEOPLASMS; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE;

EID: 69149099134     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0813055106     Document Type: Article

References (35)

1. Lee JT, et al. (2008) Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle 7:1745-1762.
2. Sells SF, et al. (1994) Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Cell Growth Differ 5:457-466.
3. Moscat J, Diaz-Meco MT (2003) Par-4 keeps the atypical PKCs at bay. Cell Cycle 2:71-72.
4. Diaz-Meco MT, et al. (1996) The product of Par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell 86:777-786.
5. Lafuente MJ, et al. (2003) Regulation of mature T lymphocyte proliferation and differentiation by Par-4. EMBO J 22:4689-4698.
6. Garcia-Cao I, et al. (2005) Tumour-suppression activity of the proapoptotic regulator Par4. EMBO Rep 6:577-583.
7. Garcia-Cao I, et al. (2003) Genetic inactivation of Par4 results in hyperactivation of NF-kB and impairment of JNK and p38. EMBO Rep 4:307-312.
8. Moreno-Bueno G, et al. (2007) Inactivation of the candidate tumor suppressor par-4 in endometrial cancer. Cancer Res 67:1927-1934.
9. Joshi J, et al. (2008) Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. EMBO J 27:2181-2193.
10. Knobbe CB, Lapin V, Suzuki A, Mak TW (2008) The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey. Oncogene 27:5398-5415.
11. Suzuki H, et al. (1998) Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res 58:204-209.
12. Cully M, You H, Levine AJ, Mak TW (2006) Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6:184-192.
13. McMenamin ME, et al. (1999) Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 59:4291-4296.
14. Stambolic V, et al. (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95:29-39.
15. Sun H, et al. (1999) PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA 96:6199-6204.
16. Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL (1998) The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci USA 95:15587-15591.
17. +/- mice. Genes Dev 20:1569-1574.
18. Trotman LC, et al. (2006) Identification of a tumour suppressor network opposing nuclear Akt function. Nature 441:523-527.
19. Kim MJ, et al. (2002) Cooperativity of Nkx3.1 and Pten loss of function in amouse model of prostate carcinogenesis. Proc Natl Acad Sci USA 99:2884-2889.
20. Bai F, Pei XH, Pandolfi PP, Xiong Y (2006) p18Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. Mol Cell Biol 26:4564-4576.
21. Di Cristofano A, De Acetis M, Koff A, Cordon-Cardo C, Pandolfi PP (2001) Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nat Genet 27:222-224.
22. Majumder PK, et al. (2003) Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci USA 100:7841-7846.
23. Karin M (2006) Nuclear factor-κB in cancer development and progression. Nature 441:431-436.
24. Naugler WE, Karin M (2008) The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 14:109-119.
25. Kim MJ, et al. (2002) Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci USA 99:2884-2889.
26. Jiao J, et al. (2007) Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development. Cancer Res 67:6083-6091.
27. Yemelyanov A, et al. (2006) Effects of IKK inhibitor PS1145 on NF-kappaB function, proliferation, apoptosis and invasion activity in prostate carcinoma cells. Oncogene 25:387-398.
28. Burke JR, et al. (2003) BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 278:1450-1456.
29. Majumder PK, Sellers WR (2005) Akt-regulated pathways in prostate cancer. Oncogene 24:7465-7474.
30. Suh J, Rabson AB (2004) NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon? J Cell Biochem 91:100-117.
31. Lessard L, et al. (2006) Nuclear localization of nuclear factor-kappaB p65 in primary prostate tumors is highly predictive of pelvic lymph node metastases. Clin Cancer Res 12:5741-5745.
32. Blanco-Aparicio C, Renner O, Leal JF, Carnero A (2007) PTEN, more than the AKT pathway. Carcinogenesis 28:1379-1386.
33. Dan HC, et al. (2008) Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev 22:1490-1500.
34. Leitges M, et al. (2001) Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell 8:771-780.
35. Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet 19:348-355.