Regulation of mature T lymphocyte proliferation and differentiation by Par-4

EMBO Journal

Volumn 22, Issue 18, 2003, Pages 4689-4698

  Lafuente, María José ^a   Martin, Pilar ^a   Garcia Cao, Isabel ^b   Diaz Meco, María Teresa ^a   Serrano, Manuel ^b   Moscat, Jorge ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Atypical PKCs; B lymphocytes; NF B; Par 4; T lymphocytes

Indexed keywords

CD4 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; PROTEINASE ACTIVATED RECEPTOR 4; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL MATURATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; FIBROBLAST; GENE ACTIVATION; GENE INACTIVATION; GENE LOSS; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MITOSIS RATE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RNA TRANSLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH2 CELL;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; GENE DELETION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LYMPHOCYTE ACTIVATION; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NFATC TRANSCRIPTION FACTORS; PROTEIN KINASE C; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

ANIMALIA;

EID: 0141514011     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg460     Document Type: Article

References (23)

1. + T cell-mediated antiviral immunity. J. Exp. Med., 195, 801-810.
2. Barradas, M., Monjas, A., Diaz-Meco, M.T., Serrano, M. and Moscat, J. (1999) The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J., 18, 6362-6369.
3. Boehrer, S., Chow, K.U., Ruthardt, M., Hoelzer, D., Mitrou, P.S. and Weidmann, E. (2002) Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells. Leuk. Lymphoma, 43, 1737-1741.
4. Chow, C.-W., Dong, C., Flavell, R.A. and Davis, R.J. (2000) c-Jun NH2-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1. Mol. Cell. Biol., 20, 5227-5234.
5. + T cell activation. J. Exp. Med., 195, 811-823.
6. Crabtree, G.R. and Olson, E.N. (2002) NFAT signaling: choreographing the social lives of cells. Cell, 109, S67-S79.
7. De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D.U., Jin, R., Jones, J., Cong, R. and Franzoso, G. (2001) Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling. Nature, 414, 308-313.
8. Diaz-Meco, M.T., Municio, M.M., Frutos, S., Sanchez, P., Lozano, J., Sanz, L. and Moscat, J. (1996) The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell, 86, 777-786.
9. Diaz-Meco, M.T., Lallena, M.J., Monjas, A., Frutos, S. and Moscat, J. (1999) Inactivation of the inhibitory κB protein kinase/nuclear factor κB pathway by Par-4 expression potentiates tumor necrosis factor α-induced apoptosis. J. Biol. Chem., 274, 19606-19612.
10. Dong, C., Yang, D.D., Wysk, M., Whitmarsh, A.J., Davis, R.J. and Flavell, R.A. (1998) Defective T cell differentiation in the absence of Jnk1. Science, 282, 2092-2095.
11. Dong, C., Yang, D.D., Tournier, C., Whitmarsh, A.J., Xu, J., Davis, R.J. and Flavell, R.A. (2000) JNK is required for effector T-cell function but not for T-cell activation. Nature, 405, 91-94.
12. Garcia-Cao, I., Lafuente, M., Criado, L., Diaz-Meco, M., Serrano, M. and Moscat, J. (2003) Genetic inactivation of Par4 results in hyperactivation of NF-κB and impairment of JNK and p38. EMBO rep., 4, 307-312.
13. Kontgen, F., Grumont, R.J., Strasser, A., Metcalf, D., Li, R., Tarlinton, D. and Gerondakis, S. (1995) Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity and interleukin-2 expression. Genes Dev., 9, 1965-1977.
14. Lallena, M.J., Diaz-Meco, M.T., Bren, G., Pay, C.V. and Moscat, J. (1999) Activation of IκB kinase β by protein kinase C isoforms. Mol. Cell. Biol., 19, 2180-2188.
15. Leitges, M. et al. (2001) Targeted disruption of the zetaPKC gene results in the impairment of the NF-κB pathway. Mol. Cell, 8, 771-780.
16. Liu, A.H. (2002) Endotoxin exposure in allergy and asthma: reconciling a paradox. J. Allergy Clin. Immunol., 109, 379-392.
17. Martin, A.G., San-Antonio, B. and Fresno, M. (2001) Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha. J. Biol. Chem., 276, 15840-15849.
18. Martin, P., Duran, A., Minguet, S., Gaspar, M.L., Diaz-Meco, M.T., Rennert, P., Leitges, M. and Moscat, J. (2002) Role of ζPKC in B-cell signaling and function. EMBO J., 21, 4049-4057.
19. Moscat, J. and Diaz-Meco, M.T. (2000) The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO rep., 1, 399-403.
20. Moscat, J., Diaz-Meco, M.T. and Rennert, P. (2003) NF-κB activation by protein kinase C isoforms and B-cell function. EMBO rep., 4, 31-36.
21. Nalca, A., Qiu, S.G., El-Guendy, N., Krishnan, S. and Rangnekar, V.M. (1999) Oncogenic Ras sensitizes cells to apoptosis by Par-4. J. Biol. Chem., 274, 29976-29983.
22. Tang, G., Minemoto, Y., Dibling, B., Purcell, N.H., Li, Z., Karin, M. and Lin, A. (2001) Inhibition of JNK activation through NF-κB target genes. Nature, 414, 313-317.
23. + T cells to Th1 cells requires MAP kinase JNK2. Immunity, 9, 575-585.