-
1
-
-
0019967975
-
The Global Deterioration Scale for assessment of primary degenerative dementia
-
Reisberg B, Ferris SH, de Leon MJ, Crook T (1982) The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 139, 1136-1139.
-
(1982)
Am J Psychiatry
, vol.139
, pp. 1136-1139
-
-
Reisberg, B.1
Ferris, S.H.2
de Leon, M.J.3
Crook, T.4
-
2
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12, 383-388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
4
-
-
84880187014
-
Alzheimer's disease: The amyloid cascade hypothesis: an update and reappraisal
-
Hardy J (2006) Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. J Alzheimers Dis 9 (3 Suppl), 151-153.
-
(2006)
J Alzheimers Dis
, vol.9
, Issue.3 SUPPL.
, pp. 151-153
-
-
Hardy, J.1
-
5
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
6
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
Hardy JA, Higgins GA (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science 256, 184-185.
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
7
-
-
0024990330
-
Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
-
Yankner BA, Duffy LK, Kirschner DA (1990) Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250, 279-282.
-
(1990)
Science
, vol.250
, pp. 279-282
-
-
Yankner, B.A.1
Duffy, L.K.2
Kirschner, D.A.3
-
8
-
-
0028986916
-
beta-amyloid fibrils induce tau phosphorylation and loss of micro-tubule binding
-
Busciglio J, Lorenzo A, Yeh J, Yankner BA (1995) beta-amyloid fibrils induce tau phosphorylation and loss of micro-tubule binding. Neuron 14, 879-888.
-
(1995)
Neuron
, vol.14
, pp. 879-888
-
-
Busciglio, J.1
Lorenzo, A.2
Yeh, J.3
Yankner, B.A.4
-
9
-
-
0028172886
-
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
-
Lorenzo A, Yankner BA (1994) Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A 91, 12243-12247.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.A.2
-
10
-
-
0035674312
-
Learning and memory in transgenic mice modeling Alzheimer's disease
-
Ashe KH (2001) Learning and memory in transgenic mice modeling Alzheimer's disease. Learn Mem 8, 301-308.
-
(2001)
Learn Mem
, vol.8
, pp. 301-308
-
-
Ashe, K.H.1
-
11
-
-
0038632272
-
Learning and memory deficits in APP trans-genic mouse models of amyloid deposition
-
Morgan D (2003) Learning and memory deficits in APP trans-genic mouse models of amyloid deposition. Neurochem Res 28, 1029-1034.
-
(2003)
Neurochem Res
, vol.28
, pp. 1029-1034
-
-
Morgan, D.1
-
12
-
-
33749361480
-
From physiopathology to treatment of Alzheimer's disease
-
Delacourte A (2006) From physiopathology to treatment of Alzheimer's disease. Rev Neurol (Paris) 162, 909-912.
-
(2006)
Rev Neurol (Paris)
, vol.162
, pp. 909-912
-
-
Delacourte, A.1
-
13
-
-
0026686938
-
Commentary and perspective on studies of beta amyloid neurotoxicity
-
Yankner BA (1992) Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol Aging 13, 615-616.
-
(1992)
Neurobiol Aging
, vol.13
, pp. 615-616
-
-
Yankner, B.A.1
-
14
-
-
0028303844
-
Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus
-
Lorenzo A, Razzaboni B, Weir GC, Yankner BA (1994) Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368, 756-760.
-
(1994)
Nature
, vol.368
, pp. 756-760
-
-
Lorenzo, A.1
Razzaboni, B.2
Weir, G.C.3
Yankner, B.A.4
-
15
-
-
0030936019
-
All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids
-
Cribbs DH, Pike CJ, Weinstein SL, Velazquez P, Cotman CW (1997) All-D-enantiomers of beta-amyloid exhibit similar biological properties to all-L-beta-amyloids. J Biol Chem 272, 7431-7436.
-
(1997)
J Biol Chem
, vol.272
, pp. 7431-7436
-
-
Cribbs, D.H.1
Pike, C.J.2
Weinstein, S.L.3
Velazquez, P.4
Cotman, C.W.5
-
16
-
-
34548291359
-
Surface structure of amyloid-beta fibrils contributes to cytotoxicity
-
Yoshiike Y, Akagi T, Takashima A (2007) Surface structure of amyloid-beta fibrils contributes to cytotoxicity. Biochemistry 46, 9805-9812.
-
(2007)
Biochemistry
, vol.46
, pp. 9805-9812
-
-
Yoshiike, Y.1
Akagi, T.2
Takashima, A.3
-
17
-
-
33344463679
-
Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
-
Glabe CG (2006) Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol Aging 27, 570-575.
-
(2006)
Neurobiol Aging
, vol.27
, pp. 570-575
-
-
Glabe, C.G.1
-
18
-
-
37048999406
-
Discovery of ADDL - targeting small molecule drugs for Alzheimer's disease
-
Look GC, Jerecic J, Cherbavaz DB, Pray TR, Breach JC, Crosier WJ, Igoudin L, Hironaka CM, Lowe RM, McEntee M, Ruslim-Litrus L, Wu HM, Zhang S, Catalano SM, Goure WF, Summa D, Krafft GA (2007) Discovery of ADDL - targeting small molecule drugs for Alzheimer's disease. Curr Alzheimer Res 4, 562-567.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 562-567
-
-
Look, G.C.1
Jerecic, J.2
Cherbavaz, D.B.3
Pray, T.R.4
Breach, J.C.5
Crosier, W.J.6
Igoudin, L.7
Hironaka, C.M.8
Lowe, R.M.9
McEntee, M.10
Ruslim-Litrus, L.11
Wu, H.M.12
Zhang, S.13
Catalano, S.M.14
Goure, W.F.15
Summa, D.16
Krafft, G.A.17
-
19
-
-
0036669881
-
Amyloid-beta oligomers: Their production, toxicity and therapeutic inhibition
-
Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ (2002) Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans 30, 552-557.
-
(2002)
Biochem Soc Trans
, vol.30
, pp. 552-557
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Rowan, M.J.4
Selkoe, D.J.5
-
20
-
-
34249672242
-
Abeta oligomers induce neuronal oxidative stress through an N-methyl-D- aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
-
De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL (2007) Abeta oligomers induce neuronal oxidative stress through an N-methyl-D- aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J Biol Chem 282, 11590-11601.
-
(2007)
J Biol Chem
, vol.282
, pp. 11590-11601
-
-
De Felice, F.G.1
Velasco, P.T.2
Lambert, M.P.3
Viola, K.4
Fernandez, S.J.5
Ferreira, S.T.6
Klein, W.L.7
-
21
-
-
0035993237
-
Abeta toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets
-
Klein WL (2002) Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochem Int 41, 345-352.
-
(2002)
Neurochem Int
, vol.41
, pp. 345-352
-
-
Klein, W.L.1
-
22
-
-
0037059598
-
Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus
-
Wang HW, Pasternak JF, Kuo H, Ristic H, Lambert MP, Chromy B, Viola KL, Klein WL, Stine WB, Krafft GA, Trom-mer BL (2002) Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res 924, 133-140.
-
(2002)
Brain Res
, vol.924
, pp. 133-140
-
-
Wang, H.W.1
Pasternak, J.F.2
Kuo, H.3
Ristic, H.4
Lambert, M.P.5
Chromy, B.6
Viola, K.L.7
Klein, W.L.8
Stine, W.B.9
Krafft, G.A.10
Trom-mer, B.L.11
-
23
-
-
34447649563
-
Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms
-
Knobloch M, Farinelli M, Konietzko U, Nitsch RM, Mansuy IM (2007) Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms. J Neurosci 27, 7648-7653.
-
(2007)
J Neurosci
, vol.27
, pp. 7648-7653
-
-
Knobloch, M.1
Farinelli, M.2
Konietzko, U.3
Nitsch, R.M.4
Mansuy, I.M.5
-
24
-
-
0037041426
-
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocam-pal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocam-pal long-term potentiation in vivo. Nature 416, 535-539.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
25
-
-
0034700622
-
Alzheimer's disease: Model behaviour
-
Chapman PF (2000) Alzheimer's disease: model behaviour. Nature 408, 915-916.
-
(2000)
Nature
, vol.408
, pp. 915-916
-
-
Chapman, P.F.1
-
26
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, DeLong CA, Wu S, Wu X, Holtzman DM, Paul SM (2002) Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 5, 452-457.
-
(2002)
Nat Neurosci
, vol.5
, pp. 452-457
-
-
Dodart, J.C.1
Bales, K.R.2
Gannon, K.S.3
Greene, S.J.4
DeMattos, R.B.5
Mathis, C.6
DeLong, C.A.7
Wu, S.8
Wu, X.9
Holtzman, D.M.10
Paul, S.M.11
-
27
-
-
21044453723
-
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo
-
Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ (2005) Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11, 556-561.
-
(2005)
Nat Med
, vol.11
, pp. 556-561
-
-
Klyubin, I.1
Walsh, D.M.2
Lemere, C.A.3
Cullen, W.K.4
Shankar, G.M.5
Betts, V.6
Spooner, E.T.7
Jiang, L.8
Anwyl, R.9
Selkoe, D.J.10
Rowan, M.J.11
-
28
-
-
0036852750
-
Ther-apeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis
-
McLaurin J, Cecal R, Kierstead ME, Tian X, Phinney AL, Manea M, French JE, Lambermon MH, Darabie AA, Brown ME, Janus C, Chishti MA, Horne P, Westaway D, Fraser PE, Mount HT, Przybylski M, St George-Hyslop P (2002) Ther-apeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis. Nat Med 8, 1263-1269.
-
(2002)
Nat Med
, vol.8
, pp. 1263-1269
-
-
McLaurin, J.1
Cecal, R.2
Kierstead, M.E.3
Tian, X.4
Phinney, A.L.5
Manea, M.6
French, J.E.7
Lambermon, M.H.8
Darabie, A.A.9
Brown, M.E.10
Janus, C.11
Chishti, M.A.12
Horne, P.13
Westaway, D.14
Fraser, P.E.15
Mount, H.T.16
Przybylski, M.17
St George-Hyslop, P.18
-
29
-
-
84984755327
-
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW (2000) A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408, 982-985.
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
Ugen, K.E.4
Dickey, C.5
Hardy, J.6
Duff, K.7
Jantzen, P.8
DiCarlo, G.9
Wilcock, D.10
Connor, K.11
Hatcher, J.12
Hope, C.13
Gordon, M.14
Arendash, G.W.15
-
30
-
-
0035132326
-
Amyloid beta vaccination: Reduced plaques and improved cognition
-
Younkin SG (2001) Amyloid beta vaccination: reduced plaques and improved cognition. Nat Med 7, 18-19.
-
(2001)
Nat Med
, vol.7
, pp. 18-19
-
-
Younkin, S.G.1
-
31
-
-
47149112621
-
Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
-
Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA (2008) Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372, 216-223.
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
Yadegarfar, G.4
Hopkins, V.5
Bayer, A.6
Jones, R.W.7
Bullock, R.8
Love, S.9
Neal, J.W.10
Zotova, E.11
Nicoll, J.A.12
-
32
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.Q.8
Mucke, L.9
-
33
-
-
0344653664
-
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
-
Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Pe-tersen RC, Parisi JE, Hyman BT (1997) Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 41, 17-24.
-
(1997)
Ann Neurol
, vol.41
, pp. 17-24
-
-
Gomez-Isla, T.1
Hollister, R.2
West, H.3
Mui, S.4
Growdon, J.H.5
Pe-tersen, R.C.6
Parisi, J.E.7
Hyman, B.T.8
-
34
-
-
0003374626
-
Tau protein pathology in neurodegenerative diseases
-
Spillantini MG, Goedert M (1998) Tau protein pathology in neurodegenerative diseases. Trends Neurosci 21, 428-433.
-
(1998)
Trends Neurosci
, vol.21
, pp. 428-433
-
-
Spillantini, M.G.1
Goedert, M.2
-
35
-
-
0034971707
-
Missense and splice site mutations in tau associated with FTDP-17: Multiple pathogenic mechanisms
-
Hutton M (2001) Missense and splice site mutations in tau associated with FTDP-17: multiple pathogenic mechanisms. Neurology 56 (11 Suppl 4), 21-25.
-
(2001)
Neurology
, vol.56
, Issue.11 SUPPL. 4
, pp. 21-25
-
-
Hutton, M.1
-
36
-
-
0034530634
-
Molecular genetics of chromosome 17 tauopathies
-
Hutton M (2000) Molecular genetics of chromosome 17 tauopathies. Ann N Y Acad Sci 920, 63-73.
-
(2000)
Ann N Y Acad Sci
, vol.920
, pp. 63-73
-
-
Hutton, M.1
-
37
-
-
0036892302
-
Tau gene mutations: Dissecting the pathogenesis of FTDP-17
-
Ingram EM, Spillantini MG (2002) Tau gene mutations: dissecting the pathogenesis of FTDP-17. Trends Mol Med 8, 555-562.
-
(2002)
Trends Mol Med
, vol.8
, pp. 555-562
-
-
Ingram, E.M.1
Spillantini, M.G.2
-
38
-
-
0034718203
-
Tau mutationsin frontotem-poral dementia FTDP-17 and their relevance for Alzheimer's disease
-
GoedertM,SpillantiniMG(2000) Tau mutationsin frontotem-poral dementia FTDP-17 and their relevance for Alzheimer's disease. Biochim Biophys Acta 1502, 110-121.
-
(2000)
Biochim Biophys Acta
, vol.1502
, pp. 110-121
-
-
Goedert, M.1
Spillantini, M.G.2
-
39
-
-
2642587240
-
Phenotypic variation in frontotem-poral dementia and parkinsonism linked to chromosome 17
-
van Swieten JC, Rosso SM, van Herpen E, Kamphorst W, Ravid R, Heutink P (2004) Phenotypic variation in frontotem-poral dementia and parkinsonism linked to chromosome 17. Dement Geriatr Cogn Disord 17, 261-264.
-
(2004)
Dement Geriatr Cogn Disord
, vol.17
, pp. 261-264
-
-
van Swieten, J.C.1
Rosso, S.M.2
van Herpen, E.3
Kamphorst, W.4
Ravid, R.5
Heutink, P.6
-
40
-
-
0029686696
-
Evolution of the neuropathology of Alzheimer's disease
-
Braak H, Braak E (1996) Evolution of the neuropathology of Alzheimer's disease. Acta Neurol Scand Suppl 165, 3-12.
-
(1996)
Acta Neurol Scand Suppl
, vol.165
, pp. 3-12
-
-
Braak, H.1
Braak, E.2
-
41
-
-
0027973771
-
Hip-pocampal connectivity and Alzheimer's dementia: Effects of synapse loss and tangle frequency in a two-component model
-
Samuel W, Masliah E, Hill LR, Butters N, Terry R (1994) Hip-pocampal connectivity and Alzheimer's dementia: effects of synapse loss and tangle frequency in a two-component model. Neurology 44, 2081-2088.
-
(1994)
Neurology
, vol.44
, pp. 2081-2088
-
-
Samuel, W.1
Masliah, E.2
Hill, L.R.3
Butters, N.4
Terry, R.5
-
42
-
-
0028277551
-
Preliminary evidence: Decreased GAP-43 message in tangle-bearing neurons relative to adjacent tangle-free neurons in Alzheimer's disease parahippocampal gyrus
-
Callahan LM, Selski DJ, Martzen MR, Cheetham JE, Coleman PD (1994) Preliminary evidence: decreased GAP-43 message in tangle-bearing neurons relative to adjacent tangle-free neurons in Alzheimer's disease parahippocampal gyrus. Neurobi-ol Aging 15, 381-386.
-
(1994)
Neurobi-ol Aging
, vol.15
, pp. 381-386
-
-
Callahan, L.M.1
Selski, D.J.2
Martzen, M.R.3
Cheetham, J.E.4
Coleman, P.D.5
-
43
-
-
0030447498
-
Microtubule-associated proteins regulate microtubule function as the track for intracellular membrane organelle transports
-
Sato-Harada R, Okabe S, Umeyama T, Kanai Y, Hirokawa N (1996) Microtubule-associated proteins regulate microtubule function as the track for intracellular membrane organelle transports. Cell Struct Funct 21, 283-295.
-
(1996)
Cell Struct Funct
, vol.21
, pp. 283-295
-
-
Sato-Harada, R.1
Okabe, S.2
Umeyama, T.3
Kanai, Y.4
Hirokawa, N.5
-
44
-
-
0037128935
-
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
-
Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM (2002) Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 156, 1051-1063.
-
(2002)
J Cell Biol
, vol.156
, pp. 1051-1063
-
-
Stamer, K.1
Vogel, R.2
Thies, E.3
Mandelkow, E.4
Mandelkow, E.M.5
-
45
-
-
33947307791
-
Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1
-
Thies E, Mandelkow EM (2007) Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci 27, 2896-2907.
-
(2007)
J Neurosci
, vol.27
, pp. 2896-2907
-
-
Thies, E.1
Mandelkow, E.M.2
-
46
-
-
39749165656
-
Differential regulation of dynein and kinesin motor proteins by tau
-
Dixit R, Ross JL, Goldman YE Holzbaur EL (2008) Differential regulation of dynein and kinesin motor proteins by tau. Science 319, 1086-1089.
-
(2008)
Science
, vol.319
, pp. 1086-1089
-
-
Dixit, R.1
Ross, J.L.2
Goldman, Y.E.3
Holzbaur, E.L.4
-
47
-
-
34250317264
-
Tau binding to microtubules does not directly affect microtubule-based vesicle motility
-
Morfini G, Pigino G, Mizuno N, Kikkawa M, Brady ST (2007) Tau binding to microtubules does not directly affect microtubule-based vesicle motility. J Neurosci Res 85, 2620-2630.
-
(2007)
J Neurosci Res
, vol.85
, pp. 2620-2630
-
-
Morfini, G.1
Pigino, G.2
Mizuno, N.3
Kikkawa, M.4
Brady, S.T.5
-
48
-
-
0033230886
-
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
-
Ishihara T, Hong M, Zhang B, Nakagawa Y, Lee MK, Tro-janowski JQ, Lee VM (1999) Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 24, 751-762.
-
(1999)
Neuron
, vol.24
, pp. 751-762
-
-
Ishihara, T.1
Hong, M.2
Zhang, B.3
Nakagawa, Y.4
Lee, M.K.5
Tro-janowski, J.Q.6
Lee, V.M.7
-
49
-
-
39549117998
-
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice
-
Yuan A, Kumar A, Peterhoff C, Duff K, Nixon RA (2008) Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci 28, 1682-1687.
-
(2008)
J Neurosci
, vol.28
, pp. 1682-1687
-
-
Yuan, A.1
Kumar, A.2
Peterhoff, C.3
Duff, K.4
Nixon, R.A.5
-
50
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingels-son M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476-481.
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
Santacruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
Ingels-son, M.6
Guimaraes, A.7
DeTure, M.8
Ramsden, M.9
McGowan, E.10
Forster, C.11
Yue, M.12
Orne, J.13
Janus, C.14
Mariash, A.15
Kuskowski, M.16
Hyman, B.17
Hutton, M.18
Ashe, K.H.19
-
51
-
-
38549120646
-
In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons
-
Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT (2008) In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci 28, 862-867.
-
(2008)
J Neurosci
, vol.28
, pp. 862-867
-
-
Spires-Jones, T.L.1
de Calignon, A.2
Matsui, T.3
Zehr, C.4
Pitstick, R.5
Wu, H.Y.6
Osetek, J.D.7
Jones, P.B.8
Bacskai, B.J.9
Feany, M.B.10
Carlson, G.A.11
Ashe, K.H.12
Lewis, J.13
Hyman, B.T.14
-
52
-
-
33947691643
-
Granular tau oligomers as intermediates of tau filaments
-
Maeda S, Sahara N, Saito Y, Murayama M, Yoshiike Y, Kim H, Miyasaka T, Murayama S, Ikai A, Takashima A (2007) Granular tau oligomers as intermediates of tau filaments. Biochemistry 46, 3856-3861.
-
(2007)
Biochemistry
, vol.46
, pp. 3856-3861
-
-
Maeda, S.1
Sahara, N.2
Saito, Y.3
Murayama, M.4
Yoshiike, Y.5
Kim, H.6
Miyasaka, T.7
Murayama, S.8
Ikai, A.9
Takashima, A.10
-
53
-
-
33244456786
-
A Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease
-
Maeda S, Sahara N, Saito Y, Murayama S, Ikai A, Takashima (2006) A Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease. Neurosci Res 54, 197-201.
-
(2006)
Neurosci Res
, vol.54
, pp. 197-201
-
-
Maeda, S.1
Sahara, N.2
Saito, Y.3
Murayama, S.4
Ikai, A.5
Takashima6
-
54
-
-
33845530335
-
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofib-rillary tangles do not revert
-
Engel T, Goni-Oliver P, Lucas JJ, Avila J, Hernandez F (2006) Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofib-rillary tangles do not revert. J Neurochem 99, 1445-1455.
-
(2006)
J Neurochem
, vol.99
, pp. 1445-1455
-
-
Engel, T.1
Goni-Oliver, P.2
Lucas, J.J.3
Avila, J.4
Hernandez, F.5
-
55
-
-
21044449225
-
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
-
Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, Gaynor K, Wang L, LaFrancois J, Feinstein B, Burns M, Krishnamurthy P, Wen Y, Bhat R, Lewis J, Dickson D, Duff K (2005) Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci U S A 102, 6990-6995.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 6990-6995
-
-
Noble, W.1
Planel, E.2
Zehr, C.3
Olm, V.4
Meyerson, J.5
Suleman, F.6
Gaynor, K.7
Wang, L.8
LaFrancois, J.9
Feinstein, B.10
Burns, M.11
Krishnamurthy, P.12
Wen, Y.13
Bhat, R.14
Lewis, J.15
Dickson, D.16
Duff, K.17
-
56
-
-
67349200953
-
Tau aggregation inhibitor (TAI) therapy with REMBER™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks
-
Wischik CM, Bentham P, Wischik DJ, Seng KM (2008) Tau aggregation inhibitor (TAI) therapy with REMBER™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks. Alzheimers Dement 4 (Suppl), T167.
-
(2008)
Alzheimers Dement
, vol.4
, Issue.SUPPL.
-
-
Wischik, C.M.1
Bentham, P.2
Wischik, D.J.3
Seng, K.M.4
-
57
-
-
17044435830
-
Tau phosphoryla-tion in Alzheimer's disease: Pathogen or protector?
-
Lee HG, Perry G, Moreira PI, Garrett MR, Liu Q, Zhu X, Takeda A, Nunomura A, Smith MA (2005) Tau phosphoryla-tion in Alzheimer's disease: pathogen or protector? Trends Mol Med 11, 164-169.
-
(2005)
Trends Mol Med
, vol.11
, pp. 164-169
-
-
Lee, H.G.1
Perry, G.2
Moreira, P.I.3
Garrett, M.R.4
Liu, Q.5
Zhu, X.6
Takeda, A.7
Nunomura, A.8
Smith, M.A.9
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