The complex relationship between folate/homocysteine metabolism and risk of Down syndrome

Mutation Research - Reviews in Mutation Research

Volumn 682, Issue 1, 2009, Pages 54-70

  Coppedè, Fabio ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

CBS; Down syndrome (DS); Epigenetics; Folate metabolism; Gene polymorphisms; Homocysteine (Hcy); MTHFR; MTR; MTRR; RFC1

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; CYSTATHIONINE BETA SYNTHASE; DNA; FOLIC ACID; HOMOCYSTEINE; METHIONINE; METHIONINE SYNTHASE; METHIONINE SYNTHASE REDUCTASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; REDUCED FOLATE CARRIER; THYMIDYLATE SYNTHASE; TRACE ELEMENT; TRANSCOBALAMIN;

ALCOHOL CONSUMPTION; AMINO ACID METABOLISM; ANEUPLOIDY; CELL TRANSPORT; CHROMOSOME 21; CHROMOSOME DAMAGE; CHROMOSOME SEGREGATION; CONCEPTION; DNA METHYLATION; DNA SYNTHESIS; DOWN SYNDROME; ENVIRONMENTAL FACTOR; EPIGENETICS; FOLATE METABOLISM; GENE FUNCTION; GENE LOCATION; GENETIC POLYMORPHISM; HEREDITY; HETEROZYGOTE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MATERNAL AGE; NONDISJUNCTION; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; TRISOMY 21;

DIET; DNA METHYLATION; DOWN SYNDROME; FOLIC ACID; HOMOCYSTEINE; HUMANS; MATERNAL AGE; METHIONINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); RISK;

EID: 68749083300     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrrev.2009.06.001     Document Type: Review

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