Abnormal folic acid-homocysteine metabolism as maternal risk factors for Down syndrome in Japan

European Journal of Nutrition

Volumn 43, Issue 5, 2004, Pages 285-287

  Takamura, Noboru ^a   Kondoh, Tatsuro ^a   Ohgi, Syohei ^a   Arisawa, Kokichi ^a   Mine, Mariko ^a   Yamashita, Shunichi ^a   Aoyagi, Kiyoshi ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

5,10 methylenetetrahydrofolate reductase gene (MTHFR); Down syndrome; Folic acid; Homocysteine

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; PYRIDOXINE;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; EVALUATION; FOOD INTAKE; GENE; HUMAN; JAPAN; MATERNAL CARE; METABOLIC REGULATION; MTHFR GENE; RISK FACTOR; SPONTANEOUS ABORTION; STATISTICAL SIGNIFICANCE; VITAMIN METABOLISM;

ADULT; DOWN SYNDROME; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; JAPAN; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; PREGNANCY; RISK FACTORS; VITAMIN B 12; VITAMIN B 6;

EID: 5644237875     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-004-0472-4     Document Type: Article

References (8)

1. Smith G, Berg J (1976) Down's anomaly. 2nd ed. Churchill Livingstone, Edinburgh and New York
2. Penrose LS (1933) The relative effects of paternal and maternal age in mongolism. J Genet 27:219
3. Hook EG (1982) Epidemiology of Down syndrome. In: Pueschel SM, Rynders JE (eds) Down Syndrome. Advances in Biomedicine and the Behavioral Sciences. Ware Press, Cambridge
4. Hook EB, Cross PK, Schreinemachers DM (1983) Chromosomal abnormality rates at amniocentesis and in live-born infants. JAMA 249:2034-2038
5. James SJ, Pogribna M, Pogribny IP, Melnyk S, Hine RJ, Gibson JB, Yi P, Tafoya DL, Swenson DH, Wilson VL, Gaylor DW (1999) Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am J Clin Nutr 70:495-501
6. Botto LD, Yang Q (2000) 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151:862-877
7. Couch SC, Cross AT, Kida K, Ros E, Plaza I, Shea S, Deckelbaum R (2000) Rapid westernization of children's blood cholesterol in 3 countries: evidence for nutrient-gene interactions? Am J Clin Nut 72:1266S-1274S
8. Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY (2001) Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 285:2981-2986