Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defect

Clinical Genetics

Volumn 53, Issue 2, 1998, Pages 119-125

  Hol, Frans A ^a   Van Der Put, Nathalie M J ^a   Geurds, Monique P A ^a   Heil, Sandra G ^a   Trijbels, Frans J M ^a   Hamel, Ben C J ^a   Mariman, Edwin C M ^a   Blom, Henk J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Folic acid; Methylenetetrahydrofolate dehydrogenase; MTHFD; Neural tube defects; Spina bifida

Indexed keywords

FOLIC ACID; FORMATE TETRAHYDROFOLATE LIGASE; METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA SEQUENCE; EXON; FOLATE METABOLISM; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC RISK; HOMOZYGOSITY; HUMAN; HUMAN CELL; INHERITANCE; INTRON; MAJOR CLINICAL STUDY; NEURAL TUBE DEFECT; PEDIGREE ANALYSIS; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SPINA BIFIDA;

EID: 0031969348     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0004.1998.tb02658.x     Document Type: Article

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