Polymorphisms in folate and homocysteine metabolizing genes and chromosome damage in mothers of Down syndrome children

American Journal of Medical Genetics, Part A

Volumn 143, Issue 17, 2007, Pages 2006-2015

  Coppedè, Fabio ^a   Colognato, Renato ^a   Bonelli, Alessia ^a   Astrea, Guja ^b   Bargagna, Stefania ^b   Siciliano, Gabriele ^a   Migliore, Lucia ^a  

^a UNIVERSITY OF PISA   (Italy)

^b DEPARTMENT OF DEVELOPMENTAL NEUROSCIENCE   (Italy)

Author keywords

Down syndrome; Folate and homocysteine metabolism; Gene polymorphisms; Micronuclei; MTHFR; MTR; RFC 1

Indexed keywords

FOLIC ACID; GENOMIC DNA; HOMOCYSTEINE; METHIONINE; METHYLENETETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ADENINE; CYTOSINE; THYMINE;

ADULT; ARTICLE; CHROMOSOME DAMAGE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DOWN SYNDROME; ENZYME SYNTHESIS; FEMALE; GENE ACTIVITY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC DISORDER; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; METABOLISM; MICRONUCLEUS TEST; MOTHER; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RISK FACTOR; AMINO ACID METABOLISM; CLINICAL ARTICLE; FOLATE METABOLISM; GENE; ITALY; MICRONUCLEUS; MTHFR GENE; NUCLEOTIDE SEQUENCE; SEQUENCE ANALYSIS;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADULT; DOWN SYNDROME; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MEMBRANE TRANSPORT PROTEINS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICRONUCLEI, CHROMOSOME-DEFECTIVE; MIDDLE AGED; MOTHERS; POLYMORPHISM, GENETIC;

EID: 34548312384     PISSN: 15524825     EISSN: 15524833     Source Type: Journal    
DOI: 10.1002/ajmg.a.31886     Document Type: Article

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