Methionine synthase (MTR) 2756 (A→G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with down syndrome

American Journal of Medical Genetics

Volumn 121 A, Issue 3, 2003, Pages 219-224

  Bosco, Paolo ^a   Guéant Rodriguez, Rosa Maria ^b   Anello, Guido ^a   Barone, Concetta ^a   Namour, Farès ^b   Caraci, Filippo ^d   Romano, Antonino ^c   Romano, Corrado ^a   Guéant, Jean Louis ^b  

^a OASI RESEARCH INSTITUTE IRCCS   (Italy)

^b INSERM   (France)

^c CATHOLIC UNIVERSITY   (Italy)

^d Cell/Molec Pathology in Nutrition ^*

Author keywords

Down syndrome; Homocysteine; Methionine synthase; Methionine synthase reductase; Methylenetetrahydro folate reductase

Indexed keywords

ADENINE; CYANOCOBALAMIN; CYSTEINE; ENZYME; FOLIC ACID; GUANINE; METHIONINE SYNTHASE; METHIONINE SYNTHASE REDUCTASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHILD; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DOWN SYNDROME; ENZYME DEFICIENCY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HOMOCYSTEINE BLOOD LEVEL; HUMAN; ITALY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; METABOLIC DISORDER; PRIORITY JOURNAL; RISK; RISK FACTOR; STATISTICAL SIGNIFICANCE;

EID: 0042194787     PISSN: 15524825     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajmg.a.20234     Document Type: Article

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