Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: Synthesis, biological evaluation, and structure - Activity relationships

Journal of Medicinal Chemistry

Volumn 52, Issue 15, 2009, Pages 4586-4595

  Häcker, Hans Georg ^a   Leyers, Stefan ^a   Wiendlocha, Jeanette ^a   Gütschow, Michael ^a   Wiese, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3,3 DIETHYLTHIOUREIDO)BENZO[B]THIOPHENE 3 CARBOXYLIC ACID; BENZOTHIOPHENE DERIVATIVE; BREAST CANCER RESISTANCE PROTEIN; CALCEIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

ATP-BINDING CASSETTE TRANSPORTERS; CARBOXYLIC ACIDS; CELL LINE, TUMOR; FEMALE; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 68549126957     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900688v     Document Type: Article

References (79)

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