New functional assay of P-glycoprotein activity using Hoechst 33342

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 23, 2007, Pages 7470-7479

  Müller, Henrik ^a   Klinkhammer, Werner ^a   Globisch, Christoph ^a   Kassack, Matthias U ^a   Pajeva, Ilza K ^a,b   Wiese, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

^b BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

Author keywords

3rd generation modulators; Hoechst 33342; Multidrug Resistance; P Glycoprotein

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CALCEIN; CISPLATIN; COLCHICINE; CYCLOSPORIN A; DAUNORUBICIN; DILTIAZEM; DOCETAXEL; DOXORUBICIN; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; HOE 33342; IMATINIB; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; NICARDIPINE; OXALIPLATIN; PROGESTERONE; RESERPINE; RHODAMINE 123; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE; WK X 34; WK X 50; XR 6577; XR 9456; XR 9577;

ANIMAL CELL; ARTICLE; BINDING SITE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME ACTIVATION; FEMALE; FLUORESCENCE; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SPACE; NONHUMAN; PHYSICAL CHEMISTRY; PRINCIPAL COMPONENT ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATASES; BENZIMIDAZOLES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; FLUORESCEINS; HUMANS; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; P-GLYCOPROTEIN; PRINCIPAL COMPONENT ANALYSIS; TIME FACTORS;

EID: 35148869733     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.024     Document Type: Article

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