ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2

Chemico-Biological Interactions

Volumn 111-112, Issue , 1998, Pages 153-161

  Keppler, D ^a   Leier, I ^a   Jedlitschky, G ^a   Konig J ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

ABC transporters; ATP dependent transport; Glucuronides; Glutathione S conjugates; MRP1; MRP2; Multidrug resistance proteins; Transport ATPases

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; BILIRUBIN GLUCURONIDE; CARCINOGEN; CHLORAMBUCIL; CISPLATIN; ETOPOSIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LEUKOTRIENE C4; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN; VINCRISTINE;

CANCER; CELL TRANSPORT; ENZYME SPECIFICITY; HUMAN; KIDNEY PROXIMAL TUBULE; LIVER CELL; NONHUMAN; OXIDATIVE STRESS; PROTEIN TRANSPORT; REVIEW;

EID: 17144465167     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(97)00158-0     Document Type: Article

References (51)

1. Combes B. The importance of conjugation with glutathione for sulfobromophthalein sodium (BSP) transfer from blood to bile. J. Clin. Invest. 44:1965;1214-1224.
2. Wahlländer A., Sies H. Glutathione S-conjugate formation from 1-chloro-2,4-dinitrobenzene and biliary S-conjugate excretion in the perfused rat liver. Eur. J. Biochem. 96:1979;441-446.
3. Kondo T., Dale G.L., Beutler E. Glutathione transport by inside-out vesicles from human erythrocytes. Proc. Natl. Acad. Sci. USA. 77:1980;6359-6362.
4. Kondo T., Murao M., Taniguchi M. Glutathione S-conjugate transport using inside-out vesicles from human erythrocytes. Eur. J. Biochem. 125:1982;551-554.
5. Kobayashi K., Sogame Y., Hayashi K., Nicotera P., Orrenius S. ATP stimulates the uptake of S-dinitrophenylglutathione by rat liver plasma membrane vesicles. FEBS Lett. 240:1988;55-58.
6. Ishikawa T., Müller M., Klünemann C., Schaub T., Keppler D. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates. J. Biol. Chem. 265:1990;19279-19286.
7. -) rats with conjugated hyperbilirubinemia. Proc. Natl. Acad. Sci. USA. 87:1990;3557-3561.
8. Akerboom T.P.M., Narayanaswami V., Kunst M., Sies H. ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver. J. Biol. Chem. 266:1991;13147-13152.
9. Fernández-Chéca J.C., Takikawa H., Horie T., Ookhtens M., Kaplowitz N. Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats. J. Biol. Chem. 267:1992;1667-1673.
10. 4 export carrier in mastocytoma cells. Eur. J. Biochem. 220:1994;599-606.
11. Jedlitschky G., Leier I., Buchholz U., Center M., Keppler D. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res. 54:1994;4833-4836.
12. 4 and structurally related conjugates. J. Biol. Chem. 269:1994;27807-27810.
13. Müller M., Meijer C., Zaman G.J.R., Borst P., Scheper R.J., Mulder N.H., de Vries E.G.E., Jansen P.L.M. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc. Natl. Acad. Sci. USA. 91:1994;13033-13037.
14. Jedlitschky G., Leier I., Buchholz U., Barnouin K., Kurz G., Keppler D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 56:1996;988-994.
15. Loe D.W., Almquist K.C., Cole S.P.C., Deeley R.G. ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J. Biol. Chem. 271:1996;9683-9689.
16. 4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport. J. Biol. Chem. 271:1996;9675-9682.
17. Cole S.P.C., Bhardwaj G., Gerlach J.H., Mackie J.E., Grant C.E., Almquist K.C., Stewart A.J., Kurz E.U., Duncan A.M.V., Deeley R.G. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science, Washington DC. 258:1992;1650-1654.
18. Marquardt D., McCrone S., Center M.S. Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein. Cancer Res. 50:1990;1426-1430.
19. Büchler M., König J., Brom M., Kartenbeck J., Spring H., Horie T., Keppler D. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J. Biol. Chem. 271:1996;15091-15098.
20. Paulusma C.C., Bosma P.J., Zaman G.J.R., Bakker C.T.M., Otter M., Scheffer G.L., Scheper R.J., Borst P., Oude Elferink R.P.J. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science. 271:1996;1126-1128.
21. D. Keppler, J. Kartenbeck, The canalicular conjugate export pump encoded by the cMRP/cMOAT gene, in: J.L. Boyer, R.K. Ockner (Eds.), Progress in Liver Diseases, vol. 14, Saunders, Philadelphia, 1996, pp. 55-67.
22. Taniguchi K., Wada M., Kohno K., Nakamura T., Kawabe T., Kawakami M., Kagotani K., Okumura K., Akiyama S., Kuwano M. A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 56:1996;4124-4129.
23. Keppler D., König J. Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J. 11:1997;509-516.
24. Schaub T.P., Kartenbeck J., König J., Vogel O., Witzgall R., Kriz W., Keppler D. Expression of the conjugate export pump encoded by the MRP2 gene in the apical membrane of kidney proximal tubules. J. Am. Soc. Nephrol. 8:1997;1213-1221.
25. Jedlitschky G., Leier I., Buchholz U., Hummel-Eisenbeiss J., Burchell B., Keppler D. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem. J. 327:1997;305-310.
26. Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J.T., Juijn J.A., Baas F., Borst P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57:1997;3537-3547.
27. Loe D.W., Deeley R.G., Cole S.P.C. Biology of the multidrug resistance-associated protein. MRP. Eur. J. Cancer. 32A:1996;945-957.
28. G.J.R. Zaman, P. Borst, MRP: mode of action and role in MDR, in: S. Gupta, T. Tsuruo (Eds.), Multidrug Resistance in Cancer Cells. Wiley, Chichester, 1996, pp. 95-107.
29. 2 terminus. J. Biol. Chem. 272:1997;23623-23630.
30. Szczypka M.S., Wemmie J.A., Moye-Rowley W.S., Thiele D.J. A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J. Biol. Chem. 269:1994;22853-22857.
31. Hipfner D.R., Gauldie S.D., Deeley R.G., Cole S.P.C. Detection of the Mr 190 000 multidrug resistance protein, MRP, with monoclonal antibodies. Cancer Res. 54:1994;5788-5792.
32. Flens M.J., Zaman G.J.R., van der Valk P., Izquierdo M.A., Schroeijers A.B., Scheffer G.L., van der Groep P., de Haas M., Meijer C.J.L.M., Scheper R.J. Tissue distribution of the multidrug resistance protein. Am. J. Pathol. 148:1996;1237-1247.
33. Mayer R., Kartenbeck J., Büchler M., Jedlitschky G., Leier I., Keppler D. Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J. Cell Biol. 131:1995;137-150.
34. Trauner M., Arrese M., Soroka C.J., Ananthanarayanan M., Koeppel T.A., Schlosser S.F., Suchy F.J., Keppler D., Boyer J.L. The rat canalicular conjugate export pump (MRP2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology. 113:1997;255-264.
35. Kubitz R., d'Urso D., Keppler D., Häussinger D. Osmodependent dynamic localization of the conjugate export pump MRP2 in the rat hepatocyte canalicular membrane. Gastroenterology. 1133:1997;1438-1442.
36. Leier I., Jedlitschky G., Buchholz U., Center M., Cole S.P.C., Deeley R.G., Keppler D. ATP-dependent glutathione disulphide transport by the MRP gene-encoded conjugate export pump. Biochem. J. 314:1996;433-437.
37. Ishikawa T. The ATP-dependent glutathione S-conjugate export pump. Trends Biochem. Sci. 17:1992;463-468.
38. Jansen P.L.M., Peters W.H.M., Lamers W.H. Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology. 5:1985;573-579.
39. Huber M., Guhlmann A., Jansen P.L.M., Keppler D. Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion. Hepatology. 7:1987;224-228.
40. Oude Elferink R.P.J., Meijer D.K.F., Kuipers F., Jansen P.L.M., Groen A.K., Groothuis G.M.M. Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim. Biophys. Acta. 1241:1995;215-268.
41. 1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene. Mol. Pharmacol. 51:1997;1034-1041.
42. Ishikawa T., Ali-Osman F. Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. J. Biol. Chem. 268:1993;20116-20126.
43. Barnouin K., Leier I., Jedlitschky G., Pourtier-Manzanedo A., König J., Lehmann W.D., Keppler D. Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. Br. J. Cancer. 77:1998;201-209.
44. T. Ishikawa, H. Sies, Glutathione as an antioxidant: toxicological aspects, in: B. Dolphin, O. Avramovic, R. Poulson (Eds.), Glutathione: Chemical, Biochemical, and Medical Aspects. Part B, Wiley, New York, 1989, pp. 85-109.
45. J. Roy Chowdhury, N. Roy Chowdhury, A.W. Wolkoff, I.M. Arias, Heme and bile pigment metabolism, in: I.M. Arias, J.L. Boyer, N. Fausto, W.B. Jakoby, D.A. Schachter, D.A. Shafritz (Eds.), The Liver: Biology and Pathobiology, Raven, New York, 1994, pp. 471-504.
46. Kartenbeck J., Leuschner U., Mayer R., Keppler D. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology. 23:1996;1061-1066.
47. Board P., Nishida T., Gatmaitan Z., Che M., Arias I.M. Erythrocyte membrane transport of glutathione conjugates and oxidized glutathione in the Dubin-Johnson syndrome and in rats with hereditary hyperbilirubinemia. Hepatology. 15:1992;722-725.
48. Paulusma C.C., Kool M., Bosma P.J., Scheffer G.L., ter Borg F., Scheper R.J., Tytgat G.N., Borst P., Baas F., Oude Elferink R.P. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology. 25:1997;1539-1542.
49. Takikawa H., Sano N., Narita T., Uchida Y., Yamanaka M., Horie T., Mikami T., Tagaya O. Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat. Hepatology. 14:1991;352-360.
50. Ito K., Suzuki H., Hirohashi T., Kume K., Shimizu T., Sugiyama Y. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am. J. Physiol. 272:1997;G16-G22.
51. Wijnholds J., Evers R., van Leusden M.R., Mol C.A., Zaman G.J., Mayer U., Beijnen J.H., van der Valk M., Krimpenfort P., Borst P. Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat. Med. 3:1997;1275-1279.