Design and Synthesis of New Templates Derived from Pyrrolopyrimidine as Selective Multidrug-Resistance-Associated Protein Inhibitors in Multidrug Resistance

Journal of Medicinal Chemistry

Volumn 47, Issue 6, 2004, Pages 1339-1350

  Wang, Shouming ^a,b   Wan, Nan Chi ^a   Harrison, John ^a   Miller, Warren ^a   Chuckowree, Irina ^a   Sohal, Sukhjit ^a   Hancox, Timothy C ^a   Baker, Stewart ^a   Folkes, Adrian ^a   Wilson, Francis ^a   Thompson, Deanne ^a   Cocks, Simon ^a   Farmer, Hayley ^a   Boyce, Anthony ^a   Freathy, Caroline ^a   Broadbridge, Jan ^a   Scott, John ^a   Depledge, Paul ^a   Faint, Richard ^a   Mistry, Prakash ^a   Charlton, Peter ^a   more..

^a Cantab Pharmaceuticals Ltd   (United Kingdom)

^b Trigen Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN; PYRIDYLINDOLOPYRIMIDINE DERIVATIVE; PYRROLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG HALF LIFE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LUNG NON SMALL CELL CANCER; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; TUMOR GROWTH; XENOGRAFT;

ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; COMBINATORIAL CHEMISTRY TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG SYNERGISM; FEMALE; HALF-LIFE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, MOLECULAR; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PYRIMIDINES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 12144290723     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0310129     Document Type: Article

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