2-(3-Aryl-2-propenoyl)-3-methylquinoxaline-1,4-dioxides: A novel cluster of tumor-specific cytotoxins which reverse multidrug resistance

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 11, 2009, Pages 3909-3915

  Das, Umashankar ^a   Pati, Hari N ^a   Panda, Atulya K ^a   Clercq, Erik De ^b   Balzarini, Jan ^b   Molnár, Joseph ^c   Baráth, Zoltán ^c   Ocsovszki, Imre ^c   Kawase, Masami ^d   Zhou, Li ^e   Sakagami, Hiroshi ^e   Dimmock, Jonathan R ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c UNIVERSITY OF SZEGED   (Hungary)

^d MATSUYAMA UNIVERSITY   (Japan)

^e MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

, Unsaturated ketones; Cytotoxicity; Multidrug resistance revertants; QSAR; Quinoxalines; Structure activity relationships

Indexed keywords

2 (3 ARYL 2 PROPENYL) 3 METHYLQUINOXALINE 1,4 DIOXIDE DERIVATIVE; 2 [3 (3,4 DICHLOROPHENYL) 2 PROPENOYL] 3 METHYLQUINOXALINE 1,4 DIOXIDE; 2 [3 (3,4 DIMETHOXYPHENYL) 2 PROPENOYL] 3 METHYLQUINOXALINE 1,4 DIOXIDE; 2 [3 (3,4 METHYLENEDIOXYPHENYL) 2 PROPENOYL] 3 METHYLQUINOXALINE 1,4 DIOXIDE; 2 [3 (4 BROMOPHENYL) 2 PROPENOYL] 3 METHYLQUINOXALINE 1,4 DIOXIDE; 2 [3 (4 CHLOROPHENYL) 2 PROPENOYL] 3 METHYLQUINOXALINE 1,4 DIOXIDE; 2 [3 (4 METHOXYPHENYL) 2 PROPENOYL] 3 METHYLQUINOXALINE 1,4 DIOXIDE; 2 ACETYL 3 METHYLQUINOXALINE 1,4 DIOXIDE; 3 METHYL 2 (3 PHENYL 2 PROPENOYL)QUINOXALINE 1,4 DIOXIDE; 3 METHYL 2 [3 (3,4,5 TRIMETHOXYPHENYL) 2 PROPENOYL]QUINOXALINE 1,4 DIOXIDE; ALDEHYDE; ANTINEOPLASTIC AGENT; CYTOTOXIN; GLYCOPROTEIN P; QUINDOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ELECTRON TRANSPORT; GENE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; LEUKEMIA L 5178 Y; LYMPHOCYTE PROLIFERATION; MDR1 GENE; MULTIDRUG RESISTANCE; NONHUMAN; PHYSICAL CHEMISTRY; PI ELECTRON SYSTEM; POLYMERIZATION; PROTON TRANSPORT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REDUCTION; STRUCTURE ACTIVITY RELATION; T CELL LEUKEMIA; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MALE; MICE; MOLECULAR STRUCTURE; NEOPLASMS; OXIDES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINOXALINES;

MURINAE;

EID: 65549122012     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.021     Document Type: Article

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