메뉴 건너뛰기




Volumn 3, Issue 2, 2009, Pages 146-158

Protein-protein interactions: Recent progress in the development of selective PDZ inhibitors

Author keywords

PDZ domain; PDZ inhibitor; Protein protein interaction (PPI)

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GLUTAMATE RECEPTOR; MONOCLONAL ANTIBODY; NSC 668036; PDZ PROTEIN; PDZ PROTEIN ANTIBODY; PDZ PROTEIN INHIBITOR; PEPTIDOMIMETIC AGENT; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 68449101708     PISSN: 18723136     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231309788166424     Document Type: Review
Times cited : (11)

References (90)
  • 1
    • 39049161143 scopus 로고    scopus 로고
    • FDA drug approvals: A year of flux
    • Hughes B. 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discovery 2008; 7: 107-9.
    • (2007) Nat Rev Drug Discovery 2008 , vol.7 , pp. 107-109
    • Hughes, B.1
  • 2
    • 23044496736 scopus 로고    scopus 로고
    • Protein-protein interactions in human disease
    • Ryan DP, Matthews JM. Protein-protein interactions in human disease. Curr Opin Struct Biol 2005; 15(4): 441-6.
    • (2005) Curr Opin Struct Biol , vol.15 , Issue.4 , pp. 441-446
    • Ryan, D.P.1    Matthews, J.M.2
  • 3
    • 0000187410 scopus 로고
    • Conversion of Phosphorylase b to Phosphorylase a in muscle extracts
    • Fischer EH, Krebs EG. Conversion of Phosphorylase b to Phosphorylase a in muscle extracts. J Biol Chem 1955; 216(1): 121-32.
    • (1955) J Biol Chem , vol.216 , Issue.1 , pp. 121-132
    • Fischer, E.H.1    Krebs, E.G.2
  • 4
    • 1642323740 scopus 로고    scopus 로고
    • Protein kinase inhibitors: Insights into drug design from structure
    • Noble MEM, Endicott JA, Johnson LN. Protein kinase inhibitors: insights into drug design from structure. Science 2004; 303(5665): 1800-5.
    • (2004) Science , vol.303 , Issue.5665 , pp. 1800-1805
    • Noble, M.E.M.1    Endicott, J.A.2    Johnson, L.N.3
  • 5
    • 0029374716 scopus 로고
    • Origin of PDZ (DHR, GLGF) domains
    • Kennedy MB. Origin of PDZ (DHR, GLGF) domains. Trends Biochem Sci 1995; 20(9): 350.
    • (1995) Trends Biochem Sci , vol.20 , Issue.9 , pp. 350
    • Kennedy, M.B.1
  • 6
    • 0026492629 scopus 로고
    • The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein
    • Cho KO, Hunt CA, Kennedy MB. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 1992; 9(5): 929-42.
    • (1992) Neuron , vol.9 , Issue.5 , pp. 929-942
    • Cho, K.O.1    Hunt, C.A.2    Kennedy, M.B.3
  • 7
    • 0025941465 scopus 로고
    • The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
    • Woods DF, Bryant PJ. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 1991; 66(3): 451-64.
    • (1991) Cell , vol.66 , Issue.3 , pp. 451-464
    • Woods, D.F.1    Bryant, P.J.2
  • 8
    • 0027300689 scopus 로고
    • The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: CDNA cloning and immunoelectron microscopy
    • Itoh M, Nagafuchi A, Yonemura S, Kitani-Yasuda T, Tsukita S, Tsukita S. The 220-kD protein colocalizing with cadherins in non-epithelial cells is identical to ZO-1, a tight junction-associated protein in epithelial cells: cDNA cloning and immunoelectron microscopy. J Cell Biol 1993; 121(3): 491-502.
    • (1993) J Cell Biol , vol.121 , Issue.3 , pp. 491-502
    • Itoh, M.1    Nagafuchi, A.2    Yonemura, S.3    Kitani-Yasuda, T.4    Tsukita, S.5    Tsukita, S.6
  • 9
    • 27144437020 scopus 로고    scopus 로고
    • The Kinetics of PDZ Domain-Ligand Interactions and Implications for the Binding Mechanism
    • Gianni S, Engstrom A, Larsson M, et al. The Kinetics of PDZ Domain-Ligand Interactions and Implications for the Binding Mechanism. J Biol Chem 2005; 280(41): 34805-12.
    • (2005) J Biol Chem , vol.280 , Issue.41 , pp. 34805-34812
    • Gianni, S.1    Engstrom, A.2    Larsson, M.3
  • 10
    • 0032568655 scopus 로고    scopus 로고
    • Schultz J, Milpetz F, Bork P, Ponting CP. SMART, a simple modular architecture research tool: Identification of signaling domains. Proc Natl Acad Sci USA 1998; 95(11): 5857-64.
    • Schultz J, Milpetz F, Bork P, Ponting CP. SMART, a simple modular architecture research tool: Identification of signaling domains. Proc Natl Acad Sci USA 1998; 95(11): 5857-64.
  • 11
    • 33644877451 scopus 로고    scopus 로고
    • Letunic I, Copley RR, Pils B, Pinkert S, Schultz J, Bork P. SMART 5: domains in the context of genomes and networks. Nucleic Acids Res 2006; 34(Database issue).
    • Letunic I, Copley RR, Pils B, Pinkert S, Schultz J, Bork P. SMART 5: domains in the context of genomes and networks. Nucleic Acids Res 2006; 34(Database issue).
  • 12
    • 2342531574 scopus 로고    scopus 로고
    • Jelen F, Olesky A, Smietana K, Otlewski J. PDZ Domains - Common players in the cell signaling. Acta Biochim Pol 2003; 50(4): 985-1017.
    • Jelen F, Olesky A, Smietana K, Otlewski J. PDZ Domains - Common players in the cell signaling. Acta Biochim Pol 2003; 50(4): 985-1017.
  • 15
    • 9644302736 scopus 로고    scopus 로고
    • PDZ-containing proteins: Alternative splicing as a source of functional diversity
    • Sierralta J, Mendoza C. PDZ-containing proteins: alternative splicing as a source of functional diversity. Brain Res Rev 2004; 47(1-3): 105-15.
    • (2004) Brain Res Rev , vol.47 , Issue.1-3 , pp. 105-115
    • Sierralta, J.1    Mendoza, C.2
  • 16
    • 1942541442 scopus 로고    scopus 로고
    • PDZ domains and their ligands
    • Kay BK, Kehoe JW. PDZ domains and their ligands. Chem Biol 2004;11(4): 423-5.
    • (2004) Chem Biol , vol.11 , Issue.4 , pp. 423-425
    • Kay, B.K.1    Kehoe, J.W.2
  • 17
    • 34249749003 scopus 로고    scopus 로고
    • Splice-isoform specific immunolocalization of neuronal nitric oxide synthase in mouse and rat brain reveals that the PDZ-complex-building nNOS β-finger is largely exposed to antibodies
    • Langnaese K, Richter K, Smalla KH, et al. Splice-isoform specific immunolocalization of neuronal nitric oxide synthase in mouse and rat brain reveals that the PDZ-complex-building nNOS β-finger is largely exposed to antibodies. Dev Neurobiol 2007; 67(4): 422-37.
    • (2007) Dev Neurobiol , vol.67 , Issue.4 , pp. 422-437
    • Langnaese, K.1    Richter, K.2    Smalla, K.H.3
  • 18
    • 0033617473 scopus 로고    scopus 로고
    • Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex
    • Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science 1999; 284(5415): 812-5.
    • (1999) Science , vol.284 , Issue.5415 , pp. 812-815
    • Hillier, B.J.1    Christopherson, K.S.2    Prehoda, K.E.3    Bredt, D.S.4    Lim, W.A.5
  • 19
    • 38049178969 scopus 로고    scopus 로고
    • Domain swapping within PDZ2 is responsible for dimerization of ZO proteins
    • Fanning AS, Lye MF, Anderson JM, Lavie A. Domain swapping within PDZ2 is responsible for dimerization of ZO proteins. J Biol Chem 2007; 282(52): 37710-6.
    • (2007) J Biol Chem , vol.282 , Issue.52 , pp. 37710-37716
    • Fanning, A.S.1    Lye, M.F.2    Anderson, J.M.3    Lavie, A.4
  • 21
    • 33747686482 scopus 로고    scopus 로고
    • Dimerization of the scaffolding protein ZO-1 through the second PDZ domain
    • Utepbergenov DI, Fanning AS, Anderson JM. Dimerization of the scaffolding protein ZO-1 through the second PDZ domain. J Biol Chem 2006; 281(34): 24671-7.
    • (2006) J Biol Chem , vol.281 , Issue.34 , pp. 24671-24677
    • Utepbergenov, D.I.1    Fanning, A.S.2    Anderson, J.M.3
  • 23
    • 33749511033 scopus 로고    scopus 로고
    • Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study
    • Basdevant N, Weinstein H, Ceruso M. Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study. J Am Chem Soc 2006; 128(39): 12766-77.
    • (2006) J Am Chem Soc , vol.128 , Issue.39 , pp. 12766-12777
    • Basdevant, N.1    Weinstein, H.2    Ceruso, M.3
  • 24
    • 4744353840 scopus 로고    scopus 로고
    • Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding Peptides
    • Wiedemann U, Boisguerin P, Leben R, Leitner D, Krause G, Moelling K. Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding Peptides. J Mol Biol 2004; 343(3): 703-18.
    • (2004) J Mol Biol , vol.343 , Issue.3 , pp. 703-718
    • Wiedemann, U.1    Boisguerin, P.2    Leben, R.3    Leitner, D.4    Krause, G.5    Moelling, K.6
  • 25
    • 0030604722 scopus 로고    scopus 로고
    • Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
    • Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ. Cell 1996; 85(7): 1067-76.
    • (1996) Cell , vol.85 , Issue.7 , pp. 1067-1076
    • Doyle, D.A.1    Lee, A.2    Lewis, J.3    Kim, E.4    Sheng, M.5    MacKinnon, R.6
  • 26
    • 17144377429 scopus 로고    scopus 로고
    • Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from neurexin and Bcr
    • Zhou H, Xu Y, Yang Y, Huang A, Wu J, Shi Y. Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from neurexin and Bcr. J Biol Chem 2005; 280(14): 13841-7.
    • (2005) J Biol Chem , vol.280 , Issue.14 , pp. 13841-13847
    • Zhou, H.1    Xu, Y.2    Yang, Y.3    Huang, A.4    Wu, J.5    Shi, Y.6
  • 27
    • 0038724238 scopus 로고    scopus 로고
    • Dev KK, Van Der Putten H, Sommer B, Rovelli G. Part I: Parkin-associated proteins and Parkinson's disease. Neuropharmacology 2003; 45(1): 1-13.
    • Dev KK, Van Der Putten H, Sommer B, Rovelli G. Part I: Parkin-associated proteins and Parkinson's disease. Neuropharmacology 2003; 45(1): 1-13.
  • 28
    • 0037016687 scopus 로고    scopus 로고
    • Parkin and CASK/ LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain
    • Fallon L, Moreau F, Croft BG, Labib N, Gu WJ, Fon EA. Parkin and CASK/ LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J Biol Chem 2002; 277(1): 486-91.
    • (2002) J Biol Chem , vol.277 , Issue.1 , pp. 486-491
    • Fallon, L.1    Moreau, F.2    Croft, B.G.3    Labib, N.4    Gu, W.J.5    Fon, E.A.6
  • 29
    • 15644379801 scopus 로고    scopus 로고
    • Recognition of unique carboxyl-terminal motifs by distinct PDZ domains
    • Songyang Z, Fanning AS, Fu C, et al. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 1997; 275(5296): 73-7.
    • (1997) Science , vol.275 , Issue.5296 , pp. 73-77
    • Songyang, Z.1    Fanning, A.S.2    Fu, C.3
  • 30
    • 0032485028 scopus 로고    scopus 로고
    • The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins
    • Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P. The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. Oncogene 1998;16(5): 643-54.
    • (1998) Oncogene , vol.16 , Issue.5 , pp. 643-654
    • Rousset, R.1    Fabre, S.2    Desbois, C.3    Bantignies, F.4    Jalinot, P.5
  • 31
    • 33646845634 scopus 로고    scopus 로고
    • Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation
    • Zhang L, Gao X, Wen J, Ning Y, Chen YG. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. J Biol Chem 2006; 281(13): 8607-12.
    • (2006) J Biol Chem , vol.281 , Issue.13 , pp. 8607-8612
    • Zhang, L.1    Gao, X.2    Wen, J.3    Ning, Y.4    Chen, Y.G.5
  • 32
    • 0037449799 scopus 로고    scopus 로고
    • Novel Mode of Ligand Recognition by the Erbin PDZ Domain
    • Birrane G, Chung J, Ladias JAA. Novel Mode of Ligand Recognition by the Erbin PDZ Domain. J Biol Chem 2003; 278(3): 1399-402.
    • (2003) J Biol Chem , vol.278 , Issue.3 , pp. 1399-1402
    • Birrane, G.1    Chung, J.2    Ladias, J.A.A.3
  • 33
    • 0037470140 scopus 로고    scopus 로고
    • Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the erbin PDZ domain
    • Skelton NJ, Koehler MFT, Zobel K, et al. Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the erbin PDZ domain. J Biol Chem 2003; 278(9): 7645-54.
    • (2003) J Biol Chem , vol.278 , Issue.9 , pp. 7645-7654
    • Skelton, N.J.1    Koehler, M.F.T.2    Zobel, K.3
  • 34
    • 0033635165 scopus 로고    scopus 로고
    • Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins
    • Xia J, Chung HJ, Wihler C, Huganir RL, Linden DJ. Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron 2000; 28(2): 499-510.
    • (2000) Neuron , vol.28 , Issue.2 , pp. 499-510
    • Xia, J.1    Chung, H.J.2    Wihler, C.3    Huganir, R.L.4    Linden, D.J.5
  • 35
    • 0036301446 scopus 로고    scopus 로고
    • Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the β2-β3 loop to PDZ domain-ligand interactions
    • Kozlov G, Banville D, Gehring K, Ekiel I. Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the β2-β3 loop to PDZ domain-ligand interactions. J Mol Biol 2002; 320(4): 813-20.
    • (2002) J Mol Biol , vol.320 , Issue.4 , pp. 813-820
    • Kozlov, G.1    Banville, D.2    Gehring, K.3    Ekiel, I.4
  • 36
    • 33947412686 scopus 로고    scopus 로고
    • Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: Mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein
    • Zhang Y, Dasgupta J, Ma RZ, Banks L, Thomas M, Chen XS. Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: Mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein. J Virol 2007; 81(7): 3618-26.
    • (2007) J Virol , vol.81 , Issue.7 , pp. 3618-3626
    • Zhang, Y.1    Dasgupta, J.2    Ma, R.Z.3    Banks, L.4    Thomas, M.5    Chen, X.S.6
  • 37
    • 0033815457 scopus 로고    scopus 로고
    • Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins
    • Lee SS, Glaunsinger B, Mantovani F, Banks L, Javier RT. Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J Virol 2000; 74(20): 9680-93.
    • (2000) J Virol , vol.74 , Issue.20 , pp. 9680-9693
    • Lee, S.S.1    Glaunsinger, B.2    Mantovani, F.3    Banks, L.4    Javier, R.T.5
  • 38
    • 21644453023 scopus 로고    scopus 로고
    • Protein/protein interactions (PDZ) in proximal tubules
    • Biber J, Gisler SM, Hernando N, Murer H. Protein/protein interactions (PDZ) in proximal tubules. J Membr Biol 2005; 203(3): 111-8.
    • (2005) J Membr Biol , vol.203 , Issue.3 , pp. 111-118
    • Biber, J.1    Gisler, S.M.2    Hernando, N.3    Murer, H.4
  • 39
    • 33750331486 scopus 로고    scopus 로고
    • Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans
    • Aceto D, Beers M, Kemphues KJ. Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. Dev Biol 2006; 299(2): 386-97.
    • (2006) Dev Biol , vol.299 , Issue.2 , pp. 386-397
    • Aceto, D.1    Beers, M.2    Kemphues, K.J.3
  • 40
    • 10444276589 scopus 로고    scopus 로고
    • Making protein interactions druggable: Targeting PDZ domains
    • Dev KK. Making protein interactions druggable: Targeting PDZ domains. Nat Rev Drug Discovery 2004; 3(12): 1047-56.
    • (2004) Nat Rev Drug Discovery , vol.3 , Issue.12 , pp. 1047-1056
    • Dev, K.K.1
  • 41
    • 20144374482 scopus 로고    scopus 로고
    • Molecular determinants for the complex binding specificity of the PDZ domain in PICK1
    • Madsen KL, Beuming T, Niv MY, Chang CW, Dev KK, Weinstein H, et al. Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. J Biol Chem 2005; 280(21): 20539-48.
    • (2005) J Biol Chem , vol.280 , Issue.21 , pp. 20539-20548
    • Madsen, K.L.1    Beuming, T.2    Niv, M.Y.3    Chang, C.W.4    Dev, K.K.5    Weinstein, H.6
  • 42
    • 34248214225 scopus 로고    scopus 로고
    • NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD95
    • Pegan S, Tan J, Huang A, Slesinger PA, Riek R, Choe S. NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD95. Biochem 2007; 46(18): 5315-22.
    • (2007) Biochem , vol.46 , Issue.18 , pp. 5315-5322
    • Pegan, S.1    Tan, J.2    Huang, A.3    Slesinger, P.A.4    Riek, R.5    Choe, S.6
  • 43
    • 33645132429 scopus 로고    scopus 로고
    • Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli
    • Takizawa S, Nagasaka K, Nakagawa S, et al. Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells 2006; 11(4): 453-64.
    • (2006) Genes Cells , vol.11 , Issue.4 , pp. 453-464
    • Takizawa, S.1    Nagasaka, K.2    Nakagawa, S.3
  • 45
    • 0035910415 scopus 로고    scopus 로고
    • c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes
    • Toyofuku T, Akamatsu Y, Zhang H, Kuzuya T, Tada M, Hori M. c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes. J Biol Chem 2001; 276(3): 1780-8.
    • (2001) J Biol Chem , vol.276 , Issue.3 , pp. 1780-1788
    • Toyofuku, T.1    Akamatsu, Y.2    Zhang, H.3    Kuzuya, T.4    Tada, M.5    Hori, M.6
  • 46
    • 0025272240 scopus 로고
    • Rapid and sensitive sequence comparison with FASTP and FASTA
    • Pearson WR. Rapid and sensitive sequence comparison with FASTP and FASTA. Methods Enzymol 1990; 183: 63-98.
    • (1990) Methods Enzymol , vol.183 , pp. 63-98
    • Pearson, W.R.1
  • 47
    • 0035861856 scopus 로고    scopus 로고
    • Classification of PDZ domains
    • Bezprozvanny I, Maximov A. Classification of PDZ domains. FEBS Letters 2001; 509(3): 457-62.
    • (2001) FEBS Letters , vol.509 , Issue.3 , pp. 457-462
    • Bezprozvanny, I.1    Maximov, A.2
  • 48
    • 0036876382 scopus 로고    scopus 로고
    • Signaling complex organization by PDZ domain proteins
    • Fan JS, Zhang M. Signaling complex organization by PDZ domain proteins. NeuroSignals 2002; 11(6): 315-21.
    • (2002) NeuroSignals , vol.11 , Issue.6 , pp. 315-321
    • Fan, J.S.1    Zhang, M.2
  • 49
    • 0034645726 scopus 로고    scopus 로고
    • Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95
    • Tochio H, Hung F, Li M, Bredt DS, Zhang M. Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95. J Mol Biol 2000; 295(2): 225-37.
    • (2000) J Mol Biol , vol.295 , Issue.2 , pp. 225-237
    • Tochio, H.1    Hung, F.2    Li, M.3    Bredt, D.S.4    Zhang, M.5
  • 50
    • 28244435950 scopus 로고    scopus 로고
    • mda-9/Syntenin: A Positive Regulator of Melanoma Metastasis
    • Boukerche H, Su Z-z, Emdad L, et al. mda-9/Syntenin: A Positive Regulator of Melanoma Metastasis. Cancer Res 2005; 65(23): 10901-11.
    • (2005) Cancer Res , vol.65 , Issue.23 , pp. 10901-10911
    • Boukerche, H.1    Su, Z.-Z.2    Emdad, L.3
  • 51
    • 16544367970 scopus 로고    scopus 로고
    • Melanoma metastasis is associated with enhanced expression of the syntenin gene
    • Helmke B, Polychronidis M, Benner A, Thome M, Arribas J, Deichmann M. Melanoma metastasis is associated with enhanced expression of the syntenin gene. Oncol Rep 2004; 12(2): 221-8.
    • (2004) Oncol Rep , vol.12 , Issue.2 , pp. 221-228
    • Helmke, B.1    Polychronidis, M.2    Benner, A.3    Thome, M.4    Arribas, J.5    Deichmann, M.6
  • 52
    • 0037071898 scopus 로고    scopus 로고
    • Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines
    • Tae HK, Lee JJ, Kim E-M, Kim KW, Han DK, Lee JH. Syntenin is overexpressed and promotes cell migration in metastatic human breast and gastric cancer cell lines. Oncogene 2002; 21(26): 4080-8.
    • (2002) Oncogene , vol.21 , Issue.26 , pp. 4080-4088
    • Tae, H.K.1    Lee, J.J.2    Kim, E.-M.3    Kim, K.W.4    Han, D.K.5    Lee, J.H.6
  • 53
    • 34249308194 scopus 로고    scopus 로고
    • PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response
    • Ayllon V, O'Connor R. PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response. Oncogene 2007; 26(24): 3451-61.
    • (2007) Oncogene , vol.26 , Issue.24 , pp. 3451-3461
    • Ayllon, V.1    O'Connor, R.2
  • 54
    • 34248216496 scopus 로고    scopus 로고
    • The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells
    • Cardone R, Bellizzi A, Busco G, Weinman E, Dell'Aquila M, Casavola V. The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells. Mol Biol Cell 2007; 18(5): 1768-80.
    • (2007) Mol Biol Cell , vol.18 , Issue.5 , pp. 1768-1780
    • Cardone, R.1    Bellizzi, A.2    Busco, G.3    Weinman, E.4    Dell'Aquila, M.5    Casavola, V.6
  • 55
    • 34648828242 scopus 로고    scopus 로고
    • Solution structure of the hDlg/ SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein
    • Liu Y, Henry GD, Hegde RS, Baleja JD. Solution structure of the hDlg/ SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein. Biochem 2007; 46(38): 10864-74.
    • (2007) Biochem , vol.46 , Issue.38 , pp. 10864-10874
    • Liu, Y.1    Henry, G.D.2    Hegde, R.S.3    Baleja, J.D.4
  • 56
    • 16644367540 scopus 로고    scopus 로고
    • The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 on-coprotein
    • Hampson L, Li C, Oliver AW, Kitchener HC, Hampson IN. The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 on-coprotein. Int J Oncol 2004; 25(5): 1249-56.
    • (2004) Int J Oncol , vol.25 , Issue.5 , pp. 1249-1256
    • Hampson, L.1    Li, C.2    Oliver, A.W.3    Kitchener, H.C.4    Hampson, I.N.5
  • 58
    • 34249859626 scopus 로고    scopus 로고
    • Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors
    • Ji H, Richter W, Namkung W, Kyung H, Kim E, Conti M. Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors. J Biol Chem 2007; 282(14): 10414-22.
    • (2007) J Biol Chem , vol.282 , Issue.14 , pp. 10414-10422
    • Ji, H.1    Richter, W.2    Namkung, W.3    Kyung, H.4    Kim, E.5    Conti, M.6
  • 59
    • 18744366911 scopus 로고    scopus 로고
    • Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia
    • Toyooka K, Iritani S, Makifuchi T, Shirakawa O, Kitamura N, Maeda K, et al. Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia. J Neurochem 2002; 83(4): 797-806.
    • (2002) J Neurochem , vol.83 , Issue.4 , pp. 797-806
    • Toyooka, K.1    Iritani, S.2    Makifuchi, T.3    Shirakawa, O.4    Kitamura, N.5    Maeda, K.6
  • 60
    • 33750215004 scopus 로고    scopus 로고
    • The schizophrenic faces of PICK1
    • Dev KK, Henley JM. The schizophrenic faces of PICK1. Trends Pharmacol Sci 2006; 27(11): 574-9.
    • (2006) Trends Pharmacol Sci , vol.27 , Issue.11 , pp. 574-579
    • Dev, K.K.1    Henley, J.M.2
  • 61
    • 34547780601 scopus 로고    scopus 로고
    • Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels
    • Joch M, Ase A, Chen C, et al. Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Mol Biol Cell 2007; 18(8): 3105-18.
    • (2007) Mol Biol Cell , vol.18 , Issue.8 , pp. 3105-3118
    • Joch, M.1    Ase, A.2    Chen, C.3
  • 63
    • 33645067624 scopus 로고    scopus 로고
    • Large-scale sequence analysis of avian influenza isolates
    • Obenauer JC, Denson J, Mehta PK, et al. Large-scale sequence analysis of avian influenza isolates. Science 2006; 311(5767): 1576-80.
    • (2006) Science , vol.311 , Issue.5767 , pp. 1576-1580
    • Obenauer, J.C.1    Denson, J.2    Mehta, P.K.3
  • 64
    • 0242383919 scopus 로고    scopus 로고
    • Effect of knock down of spinal cord PSD-93/chapsin0-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury
    • Zhang B, Tao F, Liaw WJ, Bredt DS, Johns RA, Tao YX. Effect of knock down of spinal cord PSD-93/chapsin0-110 on persistent pain induced by complete Freund's adjuvant and peripheral nerve injury. Pain 2003; 106(1-2): 187-96.
    • (2003) Pain , vol.106 , Issue.1-2 , pp. 187-196
    • Zhang, B.1    Tao, F.2    Liaw, W.J.3    Bredt, D.S.4    Johns, R.A.5    Tao, Y.X.6
  • 65
    • 0035912750 scopus 로고    scopus 로고
    • Molecular organization of the postsynaptic specialization
    • Sheng M. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci USA 2001; 98(13): 7058-61.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.13 , pp. 7058-7061
    • Sheng, M.1
  • 66
    • 3242710394 scopus 로고    scopus 로고
    • Caveolin-3 and SAP97 form a scaf-folding protein complex that regulates the voltage-gated potassium channel Kv1.5
    • Folco EJ, Liu G-X, Koren G. Caveolin-3 and SAP97 form a scaf-folding protein complex that regulates the voltage-gated potassium channel Kv1.5. Am J Physiol Heart Circ Physiol 2004; 287(2): H681-90.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , Issue.2
    • Folco, E.J.1    Liu, G.-X.2    Koren, G.3
  • 67
    • 0037475139 scopus 로고    scopus 로고
    • Role of postsynaptic density protein-95 in the maintenance of peripheral nerve injury-induced neuropathic pain in rats
    • Tao F, Tao YX, Mao P, Johns RA. Role of postsynaptic density protein-95 in the maintenance of peripheral nerve injury-induced neuropathic pain in rats. Neuroscience 2003; 117(3): 731-9.
    • (2003) Neuroscience , vol.117 , Issue.3 , pp. 731-739
    • Tao, F.1    Tao, Y.X.2    Mao, P.3    Johns, R.A.4
  • 68
    • 33646679140 scopus 로고    scopus 로고
    • Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays
    • Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G. Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. J Am Chem Soc 2006; 128(17): 5913-22.
    • (2006) J Am Chem Soc , vol.128 , Issue.17 , pp. 5913-5922
    • Stiffler, M.A.1    Grantcharova, V.P.2    Sevecka, M.3    MacBeath, G.4
  • 69
    • 0037009284 scopus 로고    scopus 로고
    • Investigation of the PDZ domain ligand binding site using chemically modified peptides
    • Novak KAP, Fujii N, Guy RK. Investigation of the PDZ domain ligand binding site using chemically modified peptides. Bioorg Med Chem Lett 2002;12(17): 2471-4.
    • (2002) Bioorg Med Chem Lett , vol.12 , Issue.17 , pp. 2471-2474
    • Novak, K.A.P.1    Fujii, N.2    Guy, R.K.3
  • 70
    • 28244496603 scopus 로고    scopus 로고
    • Identification of a specific inhibitor of the dishevelled PDZ domain
    • Shan J, Shi D-L, Wang J, Zheng J. Identification of a specific inhibitor of the dishevelled PDZ domain. Biochem 2005; 44(47): 15495-503.
    • (2005) Biochem , vol.44 , Issue.47 , pp. 15495-15503
    • Shan, J.1    Shi, D.-L.2    Wang, J.3    Zheng, J.4
  • 71
    • 68449094113 scopus 로고    scopus 로고
    • Compositions and methods for the inhibition of dishevelled proteins
    • Patent WO2006107719
    • Zheng J, Shan J, Wu D; Compositions and methods for the inhibition of dishevelled proteins. Patent WO2006107719. 2006.
    • (2006)
    • Zheng, J.1    Shan, J.2    Wu, D.3
  • 72
    • 1942509545 scopus 로고    scopus 로고
    • Targeting specific PDZ domains of PSD-95: Structural basis for enhanced affinity and enzymatic stability of a cyclic peptide
    • Piserchio A, Salinas GD, Li T, Marshall J, Spaller MR, Mierke DF. Targeting specific PDZ domains of PSD-95: Structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol 2004; 11(4): 469-73.
    • (2004) Chem Biol , vol.11 , Issue.4 , pp. 469-473
    • Piserchio, A.1    Salinas, G.D.2    Li, T.3    Marshall, J.4    Spaller, M.R.5    Mierke, D.F.6
  • 73
    • 17444383130 scopus 로고    scopus 로고
    • Bridged peptide macro-cycles as ligands for PDZ domain proteins
    • Udugamasooriya G, Saro D, Spaller MR. Bridged peptide macro-cycles as ligands for PDZ domain proteins. Org Lett 2005; 7(7): 1203-6.
    • (2005) Org Lett , vol.7 , Issue.7 , pp. 1203-1206
    • Udugamasooriya, G.1    Saro, D.2    Spaller, M.R.3
  • 74
    • 0037174635 scopus 로고    scopus 로고
    • Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions
    • Aarts M, Liu Y, Liu L, et al. Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science 2002; 298(5594): 846-50.
    • (2002) Science , vol.298 , Issue.5594 , pp. 846-850
    • Aarts, M.1    Liu, Y.2    Liu, L.3
  • 75
    • 34548636072 scopus 로고    scopus 로고
    • PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors
    • Cui H, Hayashi A, Sun HS, et al. PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci 2007; 27(37): 9901-15.
    • (2007) J Neurosci , vol.27 , Issue.37 , pp. 9901-9915
    • Cui, H.1    Hayashi, A.2    Sun, H.S.3
  • 76
    • 68449094699 scopus 로고    scopus 로고
    • Methods and Composition for treating Stroke with Fever
    • Patent WO2008008348
    • Tymianski M. Methods and Composition for treating Stroke with Fever. Patent WO2008008348. 2008.
    • (2008)
    • Tymianski, M.1
  • 78
    • 35148847766 scopus 로고    scopus 로고
    • Bivalent peptides as PDZ domain ligands
    • Klosi E, Saro D, Spaller MR. Bivalent peptides as PDZ domain ligands. Bioorg Med Chem Lett 2007; 17(22): 6147-50.
    • (2007) Bioorg Med Chem Lett , vol.17 , Issue.22 , pp. 6147-6150
    • Klosi, E.1    Saro, D.2    Spaller, M.R.3
  • 79
    • 34247257369 scopus 로고    scopus 로고
    • Synthesis of amino acid-derived cyclic acyl amidines for use in β-strand peptidomimetics
    • Hammond MC, Bartlett PA. Synthesis of amino acid-derived cyclic acyl amidines for use in β-strand peptidomimetics. J Org Chem 2007; 72(8): 3104-7.
    • (2007) J Org Chem , vol.72 , Issue.8 , pp. 3104-3107
    • Hammond, M.C.1    Bartlett, P.A.2
  • 80
    • 33845499030 scopus 로고    scopus 로고
    • Beta-strand peptidomimetics as potent PDZ domain ligands
    • Hammond MC, Harris BZ, Lim WA, Bartlett PA. Beta-strand peptidomimetics as potent PDZ domain ligands. Chem Biol 2006; 13(12): 1247-51.
    • (2006) Chem Biol , vol.13 , Issue.12 , pp. 1247-1251
    • Hammond, M.C.1    Harris, B.Z.2    Lim, W.A.3    Bartlett, P.A.4
  • 81
    • 0141958040 scopus 로고    scopus 로고
    • A selective irreversible inhibitor targeting a PDZ protein interaction domain
    • Fujii N, Novak KAP, Guy RK, Haresco JJ, Kuntz ID, Stokoe D. A selective irreversible inhibitor targeting a PDZ protein interaction domain. J Am Chem Soc 2003; 125(40): 12074-5.
    • (2003) J Am Chem Soc , vol.125 , Issue.40 , pp. 12074-12075
    • Fujii, N.1    Novak, K.A.P.2    Guy, R.K.3    Haresco, J.J.4    Kuntz, I.D.5    Stokoe, D.6
  • 82
    • 33846095971 scopus 로고    scopus 로고
    • Design of a selective chemical probe for class I PDZ domains
    • Fujii N, Shelat A, Hall RA, Kiplin Guy R. Design of a selective chemical probe for class I PDZ domains. Bioorg Med Chem Lett 2007; 17(2): 546-8.
    • (2007) Bioorg Med Chem Lett , vol.17 , Issue.2 , pp. 546-548
    • Fujii, N.1    Shelat, A.2    Hall, R.A.3    Kiplin Guy, R.4
  • 83
    • 33846061735 scopus 로고    scopus 로고
    • Rational design of a non-peptide general chemical scaffold for reversible inhibition of PDZ domain interactions
    • Fujii N, Haresco JJ, Novak KAP, et al. Rational design of a non-peptide general chemical scaffold for reversible inhibition of PDZ domain interactions. Bioorg Med Chem Lett 2007; 17(2): 549-52.
    • (2007) Bioorg Med Chem Lett , vol.17 , Issue.2 , pp. 549-552
    • Fujii, N.1    Haresco, J.J.2    Novak, K.A.P.3
  • 84
    • 33846673934 scopus 로고    scopus 로고
    • An antagonist of dishevelled protein-protein interaction suppresses β-catenin-dependent tumor cell growth
    • Fujii N, You L, Xu Z, et al. An antagonist of dishevelled protein-protein interaction suppresses β-catenin-dependent tumor cell growth. Cancer Res 2007; 67(2): 573-9.
    • (2007) Cancer Res , vol.67 , Issue.2 , pp. 573-579
    • Fujii, N.1    You, L.2    Xu, Z.3
  • 85
    • 68449100850 scopus 로고    scopus 로고
    • Preparation of aromatic heterocyclic compounds as PDZ domain inhibitors for treatment of cancer
    • Patent WO2006007542
    • Guy RK, Fujii N, You L, Jablons DM. Preparation of aromatic heterocyclic compounds as PDZ domain inhibitors for treatment of cancer. Patent WO2006007542 2006.
    • (2006)
    • Guy, R.K.1    Fujii, N.2    You, L.3    Jablons, D.M.4
  • 87
    • 68449099059 scopus 로고    scopus 로고
    • Small-Molecule inhibition of a PDZ-domain interaction
    • Patent WO20080021082
    • Guy RK, Kuntz ID, Haresco JJ, et al. Small-Molecule inhibition of a PDZ-domain interaction. Patent WO20080021082. 2008.
    • (2008)
    • Guy, R.K.1    Kuntz, I.D.2    Haresco, J.J.3
  • 89
    • 33746256483 scopus 로고    scopus 로고
    • Discovery of low-molecular-weight ligands for the AF6 PDZ domain
    • Joshi M, Vargas C, Boisguerin P, et al. Discovery of low-molecular-weight ligands for the AF6 PDZ domain. Angew Chem Int Ed 2006; 45(23): 3790-5.
    • (2006) Angew Chem Int Ed , vol.45 , Issue.23 , pp. 3790-3795
    • Joshi, M.1    Vargas, C.2    Boisguerin, P.3
  • 90
    • 68449097744 scopus 로고    scopus 로고
    • Small molecule inhibitors of PDZ interactions
    • Patent WO2007079406
    • Belmares MP, Lu PS, Mendoza KA. Small molecule inhibitors of PDZ interactions. Patent WO2007079406. 2007.
    • (2007)
    • Belmares, M.P.1    Lu, P.S.2    Mendoza, K.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.