Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the erbin PDZ domain

Journal of Biological Chemistry

Volumn 278, Issue 9, 2003, Pages 7645-7654

  Skelton, Nicholas J ^a   Koehler, Michael F T ^a   Zobel, Kerry ^a   Wong, Wai Lee ^a   Yeh, Sherry ^a   Pisabarro, M Theresa ^a   Yin, Jian Ping ^a   Lasky, Laurence A ^a   Sidhu, Sachdev S ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

LIGANDS;

PROTEINS;

ALANINE; ERBIN; LIGAND; PEPTIDE; PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG; CARRIER PROTEIN; DNA; ERBB2IP PROTEIN, HUMAN; HYBRID PROTEIN; OLIGONUCLEOTIDE; PEPTIDE LIBRARY; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; ENERGY TRANSFER; HUMAN GENOME; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PDZ DOMAIN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; GENOME; HUMAN; IC 50; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; CARRIER PROTEINS; DNA; GENOME; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGONUCLEOTIDES; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRYPTOPHAN;

EID: 0037470140     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209751200     Document Type: Article

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