Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 3, 2008, Pages 942-945

  Mayasundari, Anand ^a   Ferreira, Antonio M ^a   He, Liwen ^a   Mahindroo, Neeraj ^a   Bashford, Don ^a   Fujii, Naoaki ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

EBP50; Indole; NHERF1; PDZ domain; Protein protein interaction inhibitor; Small molecule

Indexed keywords

ADAPTOR PROTEIN; INDOLE DERIVATIVE; PDZ PROTEIN; SODIUM HYDROGEN EXCHANGER REGULATORY FACTOR 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; DRUG TARGETING; LIGAND BINDING; MATRIX ATTACHMENT REGION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY;

DRUG DESIGN; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PDZ DOMAINS; PHOSPHOPROTEINS; SODIUM-HYDROGEN ANTIPORTER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38749126768     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.038     Document Type: Article

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