Molecular determinants for the complex binding specificity of the PDZ domain in PICK1

Journal of Biological Chemistry

Volumn 280, Issue 21, 2005, Pages 20539-20548

  Madsen, Kenneth L ^a   Beuming, Thijs ^b   Niv, Masha Y ^b   Chang, Chiun Wen ^b   Dev, Kumlesh K ^c   Weinstein, Harel ^b   Gether, Ulrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; FLUORESCENCE; HYDROPHOBICITY; MATHEMATICAL MODELS; PURIFICATION; STRUCTURE (COMPOSITION);

COMPLEX BINDING; ION CHANNELS; MOLECULAR DETERMINANTS; MUTATIONAL ANALYSIS;

ENZYMES;

ASPARTYLSERYLLEUCYLLEUCINE; BETA 2 ADRENERGIC RECEPTOR; DOPAMINE TRANSPORTER; GLUTAMINYLSERYLALANYLVALINE; LEUCINE; LYSINE; PDZ PROTEIN; PROTEIN INTERACTING WITH PROTEIN KINASE C; PROTEIN KINASE C ALPHA; TRYPTOPHYLLEUCYLLYSYLVALINE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CARBOXY TERMINAL SEQUENCE; CHEMICAL MUTAGENESIS; COMPLEX FORMATION; FLUORESCENCE POLARIZATION; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; SEQUENCE ANALYSIS;

ANIMALS; BINDING SITES; CARRIER PROTEINS; COMPUTER SIMULATION; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FLUORESCENCE POLARIZATION; GLUTATHIONE TRANSFERASE; HUMANS; LYSINE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; MUTAGENESIS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; RATS; RECEPTORS, ADRENERGIC, BETA-2; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20144374482     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500577200     Document Type: Article

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