The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism

Journal of Biological Chemistry

Volumn 280, Issue 41, 2005, Pages 34805-34812

  Gianni, Stefano ^b   Engström, Åke ^a   Larsson, Mårten ^a   Calosci, Nicoletta ^b   Malatesta, Francesco ^c   Eklund, Lars ^a   Ngang, Chi Celestine ^a   Travaglini Allocatelli, Carlo ^b   Jemth, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION REACTIONS; CONFORMATIONS; DISSOCIATION; ELECTROSTATICS; GROWTH KINETICS; MUTAGENESIS; PH EFFECTS; TITRATION;

BINDING MECHANISMS; DOMAIN-LIGAND INTERACTIONS; SALT DEPENDENCE; TARGET PROTEINS;

PROTEINS;

LIGAND; MUTANT PROTEIN; PDZ PROTEIN; PEPTIDE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN PDZ2; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE L1; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION; HUMAN; MOLECULAR INTERACTION; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSTATICS; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IONS; KINETICS; LIGANDS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; SPECTROPHOTOMETRY; TEMPERATURE; THERMODYNAMICS; TIME FACTORS; TRYPTOPHAN; UREA;

EID: 27144437020     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M506017200     Document Type: Article

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