Altered functions and expressions of drug transporters in liver, kidney and intestine in disorders of local and remote organs: Possible role of oxidative stress in the pathogenesis

Expert Opinion on Drug Metabolism and Toxicology

Volumn 5, Issue 8, 2009, Pages 907-920

  Ikemura, Kenji ^a,b   Iwamoto, Takuya ^a,c   Okuda, Masahiro ^a,c  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KINJO GAKUIN UNIVERSITY   (Japan)

^c MIE UNIVERSITY HOSPITAL   (Japan)

Author keywords

ABC transporter; Bile duct ligation; Hepatic disease; Intestinal disease; Ischemia reperfusion; Oxidative stress; Pharmacokinetics; Remote organ; Renal disease; SLC transporter

Indexed keywords

4 AMINOHIPPURIC ACID; ABC TRANSPORTER; ADVANCED GLYCATION END PRODUCT; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; CIMETIDINE; CYCLOSPORIN A; GLYCOPROTEIN P; INDICAN; KIDNEY SPECIFIC ORGANIC ANION TRANSPORTER 1; KIDNEY SPECIFIC ORGANIC ANION TRANSPORTER 2; METHOTREXATE; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1; MULTIDRUG AND TOXIN EXTRUSION PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; ORGANIC CATION TRANSPORTER 4; PARACETAMOL; TACROLIMUS; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; CHOLESTASIS; CHRONIC KIDNEY FAILURE; CROHN DISEASE; DIABETIC NEPHROPATHY; DOWN REGULATION; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG METABOLISM; ENTEROPATHY; HEPATITIS; HUMAN; INTESTINE INJURY; INTESTINE ISCHEMIA; KIDNEY CLEARANCE; KIDNEY DISEASE; LIVER DISEASE; LIVER FAILURE; LIVER INJURY; LIVER ISCHEMIA; LIVER TOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN EXPRESSION; REPERFUSION INJURY; REVIEW; TOXIC HEPATITIS; ULCERATIVE COLITIS; UPREGULATION; URIC ACID NEPHROPATHY;

ANIMALS; CARRIER PROTEINS; HUMANS; INTESTINAL DISEASES; INTESTINES; KIDNEY; KIDNEY DISEASES; LIVER; LIVER DISEASES; OXIDATIVE STRESS;

EID: 68149166599     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425250903008525     Document Type: Review

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