Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rat organic cation transporter 2 (Slc22a2) and rat multidrug and toxin extrusion 1 (Slc47a1) in ischemia/reperfusion-induced acute kidney injury

Drug Metabolism and Disposition

Volumn 36, Issue 4, 2008, Pages 649-654

  Matsuzaki, Takanobu ^a   Morisaki, Takafumi ^a   Sugimoto, Wakako ^a   Yokoo, Koji ^a   Sato, Daisuke ^a   Nonoguchi, Hiroshi ^b   Tomita, Kimio ^b   Terada, Tomohiro ^c   Inui, Ken Ichi ^c   Hamada, Akinobu ^a   Saito, Hideyuki ^a  

^a KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FAMOTIDINE; MULTIDRUG AND TOXIN EXTRUSION PROTEIN; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; PROTEIN SLC47A1; TETRYLAMMONIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BASOLATERAL MEMBRANE; BRUSH BORDER; CATION EXCHANGE; CATION TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; DRUG DISPOSITION; DRUG EXCRETION; DRUG URINE LEVEL; KIDNEY CLEARANCE; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ACUTE DISEASE; ANIMALS; ANTIPORTERS; DOWN-REGULATION; FAMOTIDINE; KIDNEY; MALE; ORGANIC CATION TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

RATTUS;

EID: 41549138778     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.019869     Document Type: Article

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