Influence of chronic hepatic failure on disposition kinetics of valproate excretion through a phase II reaction in rats treated with carbon tetrachloride

Biopharmaceutics and Drug Disposition

Volumn 28, Issue 6, 2007, Pages 331-338

  Khemawoot, Phisit ^a   Maruyama, Chiharu ^a   Tsukada, Hirotaka ^a   Noda, Hiroyo ^a   Ishizaki, Junko ^a   Yokogawa, Koichi ^a   Miyamoto, Ken Ichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Chronic hepatic failure; Disposition kinetics; Glucuronidation; Mrp2; UGT; Valproate

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; GLOBULIN; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILE FLOW; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DISPOSITION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG SULFATION; DRUG URINE LEVEL; DUODENUM; ENTEROHEPATIC CIRCULATION; ENZYME ACTIVITY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INHIBITION KINETICS; KIDNEY PARENCHYMA; LIVER FAILURE; LIVER MICROSOME; LIVER PARENCHYMA; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; URINARY EXCRETION;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; ANTICONVULSANTS; AREA UNDER CURVE; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; CHRONIC DISEASE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCURONOSYLTRANSFERASE; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; LIVER; LIVER FAILURE; MALE; MEMBRANE TRANSPORT PROTEINS; METABOLIC CLEARANCE RATE; METABOLIC DETOXICATION, PHASE II; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERUM ALBUMIN; SERUM GLOBULINS; VALPROIC ACID;

EID: 34548791898     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.563     Document Type: Article

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