The molecular biology of renal organic anion and organic cation transporters

Cell Biochemistry and Biophysics

Volumn 31, Issue 1, 1999, Pages 89-118

  Sweet, Douglas H ^a   Pritchard, John B ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Expression cloning; Kidney; Liver; Organic anion; Organic cation; Transport

Indexed keywords

AMINO ACID; ANION; CATION; COMPLEMENTARY DNA;

AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GENETICS; HUMAN; ION TRANSPORT; KIDNEY; LIVER; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; REVIEW; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ANIONS; CATIONS; CLONING, MOLECULAR; DNA, COMPLEMENTARY; HUMANS; ION TRANSPORT; KIDNEY; LIVER; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0032605795     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02738157     Document Type: Article

References (77)

1. Pritchard, J. B. and Miller, D. S. (1996) Renal secretion of organic anions and cations. Kidney Int. 49, 1649-1654.
2. Ullrich, K. J. (1997) Renal transporters for organic anions and organic cations. Structural requirements for substrates. J. Membrane Biol. 158, 95-107.
3. Ullrich, K. J. (1994) Specificity of transporters for 'organic anions' and 'organic cations' in the kidney. Biochim. Biophys. Acta 1197, 45-62.
4. Lieberman, D. M., Reithmeier, R. A., Ling, V., Charuk, J. H., Goldberg, H. and Skorecki, K. L. (1989) Identification of P-glycoprotein in renal brush border membranes. Biochem. Biophys. Res. Commun. 162, 244-252.
5. Schaub, T. P., Kartenbeck, J., Konig, J., Vogel, O., Witzgall, R., Kriz, W. and Keppler, D. (1997) Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J. Am. Soc. Nephrol. 8, 1213-1221.
6. Miller, D. S., Stewart, D. E. and Pritchard, J. B. (1993) Intracellular compartmentation of organic anions within renal cells. Am. J. Physiol. 264, R882-890.
7. Pritchard, J. B., Sykes, D. B., Walden, R. and Miller, D. S. (1994) ATP-dependent transport of tetraethylammonium by endosomes isolated from rat renal cortex. Am. J. Physiol. 266, F966-976.
8. + exchanger in renal brush border membrane vesicles. J. Biol. Chem. 267, 13513-13519.
9. Pritchard, J. B. and Miller, D. S. (1993) Mechanisms mediating renal secretion of organic anions and cations. Physiol. Rev. 73, 765-796.
10. Burckhardt, G. (1984) Sodium-dependent dicarboxylate transport in rat renal basolateral membrane vesicles. Pflugers Arch. 401, 254-261.
11. Shimada, H., Moewes, B. and Burckhardt, G. (1987) Indirect coupling to Na of p-aminohippurate acid uptake into rat renal basolateral membrane vesicles. Am. J. Physiol. 253, F795-801.
12. Pritchard, J. B. (1988) Coupled transport of p-aminohippurate by rat kidney basolateral membrane vesicles. Am. J. Physiol. 255, F597-604.
13. Holohan, P. D., Pessah, N. I. and Ross, C. R. (1975) Binding of N-methylnicotinamide and p-aminohippurate acid to a particulate fraction from dog kidney. J. Pharmacol. Exp. Ther. 195, 22-33.
14. Aronson, P. S. (1989) The renal proximal tubule: a model for diversity of anion exchangers and stilbene-sensitive anion transporters. Annu. Rev. Physiol. 51, 419-441.
15. Werner, D., Martinez, F. and Roch-Ramel, F. (1990) Urate and p-aminohippurate transport in the brush border membrane of the pig kidney. J. Pharmacol. Exp. Ther. 252, 792-799.
16. Martinez, F., Manganel, M., Montrose Rafizadeh, C., Werner, D. and Roch Ramel, F. (1990) Transport of urate and p-aminohippurate in rabbit renal brush-border membranes. Am. J. Physiol. 258, F1145-1153.
17. Masereeuw, R., Russel, F. G. and Miller, D. S. (1996) Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy. Am. J. Physiol. 271, F1173-1182.
18. Pajor, A. M. (1995) Sequence and functional characterization of a renal sodium/dicarboxylate cotransporter. J. Biol. Chem. 270, 5779-5785.
19. Pajor, A. M. (1996) Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney. Am. J. Physiol. 270, F642-648.
20. +-dicarboxylate transporter. Am. J. Physiol. 275, F298-305.
21. Wright, S. H. and Wunz, T. M. (1987) Succinate and citrate transport in renal basolateral and brush-border membranes. Am. J. Physiol. 253, F432-439.
22. Wright, E. M. (1985) Transport of carboxylic acids by renal membrane vesicles. Annu. Rev. Physiol. 47, 127-141.
23. Pajor, A. M. and Sun, N. (1996) Characterization of the rabbit renal Na(+)-dicarboxylate cotransporter using antifusion protein antibodies. Am. J. Physiol. 271, C1808-1816.
24. Bai, L. and Pajor, A. M. (1997) Expression cloning of NaDC-2, an intestinal Na(+)-or Li(+)-dependent dicarboxylate transporter. Am. J. Physiol. 273, G267-274.
25. Sweet, D. H., Wolff, N. A. and Pritchard, J. B. (1997) Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J. Biol. Chem. 272, 30088-30095.
26. Sekine, T., Watanabe, N., Hosoyamada, M., Kanai, Y. and Endou, H. (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J. Biol. Chem. 272, 18526-18529.
27. Wolff, N. A., Werner, A., Burkhardt, S. and Burckhardt, G. (1997) Expression cloning and characterization of a renal organic anion transporter from winter flounder. FEBS Lett. 417, 287-291.
28. Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R. and Nigam, S. K. (1997) Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J. Biol. Chem. 272, 6471-6478.
29. Simonson, G. D., Vincent, A. C., Roberg, K. J., Huang, Y. and Iwanij, V. (1994) Molecular cloning and characterization of a novel liver-specific transport protein. J. Cell Sci. 107, 1065-1072.
30. Mori, K., Ogawa, Y., Ebihara, K., Aoki, T., Tamura, N., Sugawara, A., Kuwahara, T., Ozaki, S., Mukoyama, M., Tashiro, K., Tanaka, I. and Nakao, K. (1997) Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 417, 371-374.
31. Schweifer, N. and Barlow, D. P. (1996) The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters. Mamm. Genome 7, 735-740.
32. Sekine, T., Cha, S. H., Tsuda, M., Apiwattanakul, N., Nakajima, Y. and Endou, H. (1998) Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 429, 179-182.
33. Jacquemin, E., Hagenbuch, B., Stieger, B., Wolkoff, A. W. and Meier, P. J. (1994) Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc. Natl. Acad. Sci. USA 91, 133-137.
34. Noe, B., Hagenbuch, B., Stieger, B. and Meier, P. J. (1997) Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc. Natl. Acad. Sci. USA 94, 10346-10350.
35. Saito, H., Masuda, S. and Inui, K. (1996) Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J. Biol. Chem. 271, 20719-20725.
36. Kanai, N., Lu, R., Bao, Y., Wolkoff, A. W. and Schuster, V. L. (1996) Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am. J. Physiol. 270, F319-325.
37. Bergwerk, A. J., Shi, X., Ford, A. C., Kanai, N., Jacquemin, E., Burk, R. D., et al. (1996) Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am. J. Physiol. 271, G231-238.
38. Kullak-Ublick, G. A., Hagenbuch, B., Stieger, B., Schteingart, C. D., Hofmann, A. F., Wolkoff, A. W. and Meier, P. J. (1995) Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 109, 1274-1282.
39. Masuda, S., Saito, H., Nonoguchi, H., Tomita, K. and Inui, K. (1997) mRNA distribution and membrane localization of the OAT-K1 organic anion transporter in rat renal tubules. FEBS Lett. 407(2), 127-131.
40. Rennick, B. R. (1981) Renal tubule transport of organic cations. Am. J. Physiol. 240 (Renal Fluid Electrolyte Physiol 9), F83-89.
41. Rennick, B. R., Moe, G. K., Lyons, R. H., Hoobler, S. W. and Neligh, R. (1947) Absorption and renal excretion of the tetraethylammonium ion. J. Pharmacol. Exp. Ther. 91, 210-217.
42. Sperber, I. (1947) The mechanism of renal excretion of some detoxication products in the chicken. Proc. Int. Congr. Physiol. 17, 217-218.
43. Sperber, I. (1948) The excretion of piperidine, guanidine, methylguanidine and N-methylnicotinamide in the chicken. Lantbrukshoegsk Ann. 16, 49-64.
44. Pritchard, J. B. and Miller, D. S. (1996) Intra-cellular compartmentation of organic anions and cations during renal secretion. Cell Physiol. Biochem. 6, 50-59.
45. Ross, C. R. and Holohan, P. D. (1983) Transport of organic anions and cations in isolated renal plasma membranes. Annu. Rev. Pharmacol. Toxicol. 23, 65-85.
46. Orlowski, J., Kandasamy, R. A. and Shull, G. E. (1992) Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J. Biol. Chem. 267, 9331-9339.
47. + antiporter. Cell 56, 271-280.
48. + exchanger isoform (NHE-3). J. Biol. Chem. 267, 9340-9346.
49. + exchanger isoform (NHE-2). J. Biol. Chem. 268, 11917-11924.
50. Amemiya, M., Loffing, J., Lotscher, M., Kaissling, B., Alpern, R. J. and Moe, O. W. (1995) Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney Int. 48, 1206-1215.
51. + exchanger isoform NHE-1 in rabbit kidney. Am. J. Physiol. 263, F833-840.
52. + exchanger isofcrm of renal brush border. Am. J. Physiol. 265, F736-742.
53. Miller, D. S. (1995) Daunomycin secretion by killfish renal proximal tubules. Am. J. Physiol. 269, R370-379.
54. Grundemann, D., Gorboulev, V., Gambaryan, S., Veyhl, M. and Koepsell, H. (1994) Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372, 549-552.
55. Gorboulev, V., Ulzheimer, J. C., Akhoundova, A., Ulzheimer Teuber, I., Karbach, U., Quester, S., Baumanr, C., Lang, F., Busch, A. E. and Koepsell, H. (1997) Cloning and characterization of two human polyspecific OCTs. DNA Cell Biol. 16(7), 871-881.
56. Zhang, L., Dresser, M. J., Gray, A. T., Yost, S. C., Terashita, S. and Giacomini, K. M. (1997) Cloning and functional expression of a human liver organic cation transporter. Mol. Pharmacol. 51, 913-921.
57. Terashita, S., Dresser, M. J., Zhang, L., Gray, A. T., Yost, S. C. and Giacomini, K. M. (1998) Molecular cloning and functional expression of a rabbit renal organic cation transporter. Biochim. Biophys. Acta 1369, 1-6.
58. Okuda, M., Saito, H., Urakami, Y., Takano, M. and Inui, K. (1996) cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem. Biophys. Res. Commun. 224, 500-507.
59. Grundemann, D., Babin Ebell, J., Martel, F., Ording, N., Schmidt, A. and Schomig, E. (1997) Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells. J. Biol. Chem. 272, 10408-10413.
60. Sweet, D. H., Walsh, R. C. and Pritchard, J. B. (1996) Expression cloning and characterization of a novel organic cation transporter from rat kidney. FASEB Abstracts 10, A127.
61. Sweet, D. H., Walsh, R. C. and Pritchard, J. B. (1997) Expression cloning and characterization of a renal organic cation transporter from rat. FASEB Abstracts 11, A278.
62. Kekuda, R., Prasad, P. D., Wu, X., Wang, H., Fei, Y., Leibach, F. H. and Ganapathy, V. (1998) Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J. Biol. Chem. 273, 15971-15979.
63. Wu, X., Ganapathy, M. E., Leibach, F. H. and Ganapathy, V. (1998) Cloning and functional characterization of an organic cation transporter (OCT3) from mouse kidney. FASEB Abstracts, Part II 12, A1042.
64. Tamai, I., Yabuuchi, H., Nezu, J., Sai, Y., Oku, A., Shimane, M. and Tsuji, A. (1997) Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett. 419, 107-111.
65. Wu, X., Leibach, F. H. and Ganapathy, V. (1998) cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem. Biophys. Res. Commun. 246, 589-595.
66. Schomig, E., Spitzenberger, F., Engelhardt, M., Martel, F., Ording, N. and Grundemann, D. (1998) Molecular cloning and characterization of two novel transport proteins from rat kidney. FEBS Lett. 425(1), 79-86.
67. Needleman, S. B. and Wunsch, C. D. (1970) A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 48(3), 443-453.
68. Wisconsin Package Version 9.1 (1997) Genetics Computer Group (GCG), Madison, WI.
69. Jones, D. T., Taylor, W. R. and Thornton, J. M. (1992) The rapid generation of mutation data matrices from protein sequences. Comput. Appl. Biosci. 8, 275-282.
70. Feng, D. F., Johnson, M. S. and Doolittle, R. F. (1985) Aligning amino acid sequences: comparison of commonly used methods. J. Mol. Evol. 21, 112-125.
71. Gould, G. W. and Holman, G. D. (1993) The glucose transporter family: structure, function and tissue-specific expression. Biochem. J. 295, 329-341.
72. Griffith, J. K., Baker, M. E., Rouch, D. A., Page, M. G., Skurray, R. A., Paulsen, I. T., Chater, K. F., Baldwin, S. A. and Henderson, P. J. (1992) Membrane transport proteins: implications of sequence comparisons. Curr. Opin. Cell Biol. 4, 684-695.
73. Hohage, H., Lohr, M., Querl, U. and Greven, J. (1994) The renal basolateral transport system for organic anions: properties of the regulation mechanism. J. Pharmacol. Exp. Ther. 269, 659-664.
74. Miller, D. S. (1998) Protein kinase C regulation of organic anion transport in renal proximal tubule. Am. J. Physiol. 274, F156-164.
75. Halpin, P. A. and Renfro, J. L. (1996) Renal organic anion secretion: evidence for dopaminergic and adrenergic regulation. Am. J. Physiol. 271, R1372-1379.
76. Takano, M., Nagai, J., Yasuhara, M. and Inui, K. (1996) Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells. Am. J. Physiol. 271, F469-475.
77. Zhang, L., Dresser, M. J., Chun, J. K., Babbitt, P. C. and Giacomini, K. M. (1997) Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). J. Biol. Chem. 272(26), 16548-16554.