Testosterone-independent down-regulation of Oct2 in the kidney medulla from a uranyl nitrate-induced rat model of acute renal failure: Effects on distribution of a model organic cation, tetraethylammonium

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 739-747

  Shim, Won Sik ^a   Park, Joo Hyun ^a   Ahn, Sun Joo ^a   Han, Liwei ^a,b   Jin, Qing Ri ^a   Li, Hong ^a   Choi, Min Koo ^a   Kim, Dae Duk ^a   Chung, Suk Jae ^a   Shim, Chang Koo ^a  

^a Seoul National University   (South Korea)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Acute renal failure (ARF); Disease state; Distribution; Kidney medulla; Oct2; Organic cation transporters (OCTs); Pharmacokinetics; Renal transport; Tetraethylammonium (TEA); Uranyl nitrate (UN)

Indexed keywords

MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 2; TESTOSTERONE; TETRYLAMMONIUM; URANYL NITRATE; ORGANIC CATION TRANSPORTER; SLC22A2 PROTEIN, RAT; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; KIDNEY CLEARANCE; KIDNEY MEDULLA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; GENETICS; METABOLISM; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; KIDNEY FAILURE, ACUTE; KIDNEY MEDULLA; MALE; ORGANIC CATION TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TESTOSTERONE; TETRAETHYLAMMONIUM; TISSUE DISTRIBUTION; URANYL NITRATE;

EID: 59849111486     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21442     Document Type: Article

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