A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo

Toxicology in Vitro

Volumn 23, Issue 6, 2009, Pages 1163-1169

  Kienhuis, Anne S ^a,b   van de Poll, Marcel C G ^c   Dejong, Cornelis H C ^c   Gottschalk, Ralph ^a   van Herwijnen, Marcel ^a   Boorsma, André ^b   Kleinjans, Jos C S ^a   Stierum, Rob H ^b   van Delft, Joost H M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Coumarin; Gene expression profiling; Hepatotoxicity; Parallelogram approach; Primary human hepatocytes; Species difference; Toxicogenomics

Indexed keywords

COUMARIN;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENERGY CONSUMPTION; FEMALE; GENE EXPRESSION PROFILING; GENOMICS; HUMAN; HUMAN CELL; LIVER CELL; LIVER TOXICITY; MALE; SPECIES DIFFERENCE; TOXICOGENETICS; TRANSCRIPTOMICS;

ADULT; AGED; ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; CELLS, CULTURED; COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; MALE; MITOCHONDRIA, LIVER; RATS; SPECIES SPECIFICITY; TOXICOGENETICS;

ANIMALIA; RATTUS;

EID: 68049094980     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.06.005     Document Type: Article

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