o-Hydroxyphenylacetaldehyde is a hepatotoxic metabolite of coumarin

Drug Metabolism and Disposition

Volumn 28, Issue 2, 2000, Pages 218-223

  Born, Stephanie L ^a   Hu, Joanna K ^a   Lehman Mckeeman, Lois D ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPHENYLACETALDEHYDE; ALDEHYDE DERIVATIVE; COUMARIN; DRUG METABOLITE; LACTATE DEHYDROGENASE; TETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; ENZYME RELEASE; INCUBATION TIME; LIVER CELL; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; TOXICITY TESTING;

ACETALDEHYDE; ANIMALS; ANTICOAGULANTS; CELL SURVIVAL; CELLS, CULTURED; CHO CELLS; COUMARINS; CRICETINAE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; RODENTIA;

EID: 0033979511     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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