Species differences in coumarin metabolism: A molecular modelling evaluation of CYP2A interactions

Xenobiotica

Volumn 32, Issue 7, 2002, Pages 547-561

  Lewis, D F V ^a   Lake, B G ^b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b TNO BIBRA International Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COUMARIN; CYTOCHROME P450; CYTOCHROME P450 2A1; CYTOCHROME P450 2A5; CYTOCHROME P450 2A6; UNCLASSIFIED DRUG;

ARTICLE; EPOXIDATION; HYDROGEN BOND; HYDROXYLATION; LIPOPHILICITY; MAMMAL; METABOLISM; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CATALYTIC DOMAIN; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROGEN BONDING; MICE; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

MAMMALIA;

EID: 0036064031     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250210128693     Document Type: Article

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