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Volumn 102, Issue 3, 1998, Pages 499-506

Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-β1

Author keywords

Adoptive transfer; CD4+ and CD8+ T cells; Nonobese diabetic (NOD) mice; Pancreatic islets; Rat glucagon promoter (RGP)

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 18544392433     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2992     Document Type: Article
Times cited : (72)

References (39)
  • 1
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • Tisch, R., and H. McDevitt. 1996. Insulin-dependent diabetes mellitus. Cell. 85:291-297.
    • (1996) Cell , vol.85 , pp. 291-297
    • Tisch, R.1    McDevitt, H.2
  • 2
    • 0026646694 scopus 로고
    • The murine autoimmune diabetes model: NOD and related strains
    • Kikutani, H., and S. Makino. 1992. The murine autoimmune diabetes model: NOD and related strains. Adv. Immunol. 51:285-321.
    • (1992) Adv. Immunol. , vol.51 , pp. 285-321
    • Kikutani, H.1    Makino, S.2
  • 3
    • 0022465625 scopus 로고
    • Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth
    • Kehrl, J.H., L.M. Wakefield, A.B. Roberts, S. Jakewlew, M. Alvarez-Mon, R.B.S.M. Derynck, and A.S. Fauci. 1986. Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163:1037-1050.
    • (1986) J. Exp. Med. , vol.163 , pp. 1037-1050
    • Kehrl, J.H.1    Wakefield, L.M.2    Roberts, A.B.3    Jakewlew, S.4    Alvarez-Mon, M.5    Derynck, R.B.S.M.6    Fauci, A.S.7
  • 4
    • 0023029023 scopus 로고
    • Transforming growth factor β is an important immunomodulatory protein for human B lymphocytes
    • Kehrl, J.H., A.B. Roberts, L.M. Wakefield, S. Jakewlew, M.B. Sporn, and A.S. Fauci. 1986. Transforming growth factor β is an important immunomodulatory protein for human B lymphocytes. J. Immunol. 137:3855-3860.
    • (1986) J. Immunol. , vol.137 , pp. 3855-3860
    • Kehrl, J.H.1    Roberts, A.B.2    Wakefield, L.M.3    Jakewlew, S.4    Sporn, M.B.5    Fauci, A.S.6
  • 5
    • 0022617915 scopus 로고
    • Effects of transforming growth factor-β on the functions of natural killer cells: Depressed cytolytic activity and blunting of interferon responsiveness
    • Rook, A.H., J.H. Kehrl, L.M. Wakefield, A.B. Roberts, M.B. Sporn, D.B. Burlington, H.C. Lane, and A.S. Fauci. 1986. Effects of transforming growth factor-β on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. J. Immunol. 136:3916-3920.
    • (1986) J. Immunol. , vol.136 , pp. 3916-3920
    • Rook, A.H.1    Kehrl, J.H.2    Wakefield, L.M.3    Roberts, A.B.4    Sporn, M.B.5    Burlington, D.B.6    Lane, H.C.7    Fauci, A.S.8
  • 7
    • 0024322186 scopus 로고
    • Modulation of cytokine production by transforming growth factor-β1
    • Chantry, D., M. Turner, E. Abney, and M. Feldman. 1989. Modulation of cytokine production by transforming growth factor-β1. J. Immunol. 142:4295-4300.
    • (1989) J. Immunol. , vol.142 , pp. 4295-4300
    • Chantry, D.1    Turner, M.2    Abney, E.3    Feldman, M.4
  • 10
    • 0030030568 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 in experimental autoimmune neuritis. Cellular localization and time course
    • Kiefer, R., K. Funa, T. Schweitzer, S. Jung, O. Bourde, K.V. Toyka, and H.P. Hartung. 1996. Transforming growth factor-beta 1 in experimental autoimmune neuritis. Cellular localization and time course. Am. J. Pathol. 148: 211-223.
    • (1996) Am. J. Pathol. , vol.148 , pp. 211-223
    • Kiefer, R.1    Funa, K.2    Schweitzer, T.3    Jung, S.4    Bourde, O.5    Toyka, K.V.6    Hartung, H.P.7
  • 12
    • 0025892475 scopus 로고
    • Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1
    • Racke, M.K., S. Dhib-Jalbut, B. Canella, P.S. Albert, C.S. Raine, and D.E. Macfarlin. 1992. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1. J. Immunol. 146:3012-3017.
    • (1992) J. Immunol. , vol.146 , pp. 3012-3017
    • Racke, M.K.1    Dhib-Jalbut, S.2    Canella, B.3    Albert, P.S.4    Raine, C.S.5    Macfarlin, D.E.6
  • 13
    • 0026542168 scopus 로고
    • Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune response by the release of transforming growth factor β after antigen-specific triggering
    • Miller, A., O. Lider, A.B. Roberts, M.B. Sporn, and H.L. Weiner. 1992. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune response by the release of transforming growth factor β after antigen-specific triggering. Proc. Natl. Acad. Sci. USA. 89: 421-425.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 421-425
    • Miller, A.1    Lider, O.2    Roberts, A.B.3    Sporn, M.B.4    Weiner, H.L.5
  • 14
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen, Y., V.K. Kuchroo, J. Inobe, D.A. Hafler, and H.L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265:1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 16
    • 0028358048 scopus 로고
    • Induction of anergy or active suppression following oral tolerance is determined by antigen dosage
    • Friedman, A., and H.L. Weiner. 1994. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc. Natl. Acad. Sci. USA. 91:6688-6692.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6688-6692
    • Friedman, A.1    Weiner, H.L.2
  • 17
    • 0030035509 scopus 로고    scopus 로고
    • Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta 1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
    • Fukaura, H., S.C. Kent, M.J. Pietrusewicz, S.J. Khoury, H.L. Weiner, and D.A. Hafler. 1996. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta 1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J. Clin. Invest. 98: 70-77.
    • (1996) J. Clin. Invest. , vol.98 , pp. 70-77
    • Fukaura, H.1    Kent, S.C.2    Pietrusewicz, M.J.3    Khoury, S.J.4    Weiner, H.L.5    Hafler, D.A.6
  • 18
    • 0029744298 scopus 로고    scopus 로고
    • Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice
    • Von-Herrath, M.G., T. Dyrberg, and M.B. Oldstone. 1996. Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice. J. Clin. Invest. 98:1324-1331.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1324-1331
    • Von-Herrath, M.G.1    Dyrberg, T.2    Oldstone, M.B.3
  • 19
    • 0029838995 scopus 로고    scopus 로고
    • Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetes (NOD) mice
    • Mueller, R., T. Krahl, and N. Sarvetnick. 1996. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetes (NOD) mice. J. Exp. Med. 184:1093-1099.
    • (1996) J. Exp. Med. , vol.184 , pp. 1093-1099
    • Mueller, R.1    Krahl, T.2    Sarvetnick, N.3
  • 21
    • 0029417193 scopus 로고
    • TGF-β1 overexpression in murine pancreas induces chronic pancreatis and, together with TNF-α, triggers insulin-dependent diabetes
    • Sanvito, F., A. Nichols, P.L. Herrera, J. Huarte, A. Wohlwend, J.D. Vassalli, and L. Orci. 1995. TGF-β1 overexpression in murine pancreas induces chronic pancreatis and, together with TNF-α, triggers insulin-dependent diabetes. Biochem. Biophys. Res. Commun. 217:1279-1286.
    • (1995) Biochem. Biophys. Res. Commun. , vol.217 , pp. 1279-1286
    • Sanvito, F.1    Nichols, A.2    Herrera, P.L.3    Huarte, J.4    Wohlwend, A.5    Vassalli, J.D.6    Orci, L.7
  • 22
    • 0029926810 scopus 로고    scopus 로고
    • Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice
    • Lee, M.-S., S. Stephen, M. Arnush, T. Krahl, M. von-Herrath, M.B. Oldstone, and N. Sarvetnick. 1996. Transforming growth factor-β fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice. Transplantation. 61:1112-1113.
    • (1996) Transplantation , vol.61 , pp. 1112-1113
    • Lee, M.-S.1    Stephen, S.2    Arnush, M.3    Krahl, T.4    Von-Herrath, M.5    Oldstone, M.B.6    Sarvetnick, N.7
  • 23
    • 0026559398 scopus 로고
    • Transforming growth factor beta (TGF-β) in inflammation: A cause and cure
    • Wahl, S.M. 1992. Transforming growth factor beta (TGF-β) in inflammation: a cause and cure. J. Clin. Immunol. 12:61-74.
    • (1992) J. Clin. Immunol. , vol.12 , pp. 61-74
    • Wahl, S.M.1
  • 24
    • 0024312217 scopus 로고
    • Site-directed mutagenesis of cysteine residues in the pro-region of the transforming growth factor-β1 precursor. Expression and characterization of mutant proteins
    • Brunner, A.M., H. Marquardt, A.R. Malacko, M.N. Lioubin, and A.F. Purchio. 1989. Site-directed mutagenesis of cysteine residues in the pro-region of the transforming growth factor-β1 precursor. Expression and characterization of mutant proteins. J. Biol. Chem. 264:13660-13664.
    • (1989) J. Biol. Chem. , vol.264 , pp. 13660-13664
    • Brunner, A.M.1    Marquardt, H.2    Malacko, A.R.3    Lioubin, M.N.4    Purchio, A.F.5
  • 27
    • 0024074541 scopus 로고
    • Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic α cells
    • Efrat, S., G. Teitelman, M. Anwar, D. Ruggiero, and D. Hanahan. 1988. Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic α cells. Neuron. 1:605-613.
    • (1988) Neuron , vol.1 , pp. 605-613
    • Efrat, S.1    Teitelman, G.2    Anwar, M.3    Ruggiero, D.4    Hanahan, D.5
  • 28
    • 10244224047 scopus 로고    scopus 로고
    • Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes
    • Moritani, M., K. Yoshimoto, S. Ii, M. Kondo, H. Iwahana, T. Sano, N. Nakano, H. Kikutani, and M. Itakura. 1996. Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes. J. Clin. Invest. 98:1851-1859.
    • (1996) J. Clin. Invest. , vol.98 , pp. 1851-1859
    • Moritani, M.1    Yoshimoto, K.2    Ii, S.3    Kondo, M.4    Iwahana, H.5    Sano, T.6    Nakano, N.7    Kikutani, H.8    Itakura, M.9
  • 29
    • 0023216905 scopus 로고
    • Human transforming growth factor type beta 2: Production by a prostatic adenocarcinoma cell line, purification, and initial characterization
    • Ikeda, T., M.N. Lioubin, and H. Marquardt. 1987. Human transforming growth factor type beta 2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization. Biochemistry. 26:2406-2410.
    • (1987) Biochemistry , vol.26 , pp. 2406-2410
    • Ikeda, T.1    Lioubin, M.N.2    Marquardt, H.3
  • 30
    • 0025731505 scopus 로고
    • T cell receptor v gene usage of islet β cell-reactive T cells is not restricted in nonobese diabetic mice
    • Nakano, N., H. Kikutani, H. Nishimoto, and T. Kishimoto. 1991. T cell receptor v gene usage of islet β cell-reactive T cells is not restricted in nonobese diabetic mice. J. Exp. Med. 173:1091-1097.
    • (1991) J. Exp. Med. , vol.173 , pp. 1091-1097
    • Nakano, N.1    Kikutani, H.2    Nishimoto, H.3    Kishimoto, T.4
  • 35
    • 0030175335 scopus 로고    scopus 로고
    • + suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice
    • + suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice. J. Autoimmun. 9:331-339.
    • (1996) J. Autoimmun. , vol.9 , pp. 331-339
    • Han, H.S.1    Jun, H.S.2    Utsugi, T.3    Yoon, J.W.4
  • 36
    • 0030940348 scopus 로고    scopus 로고
    • + T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent
    • + T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent. Proc. Natl. Acad. Sci. USA. 94: 3189-3194.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3189-3194
    • Hu-Li, J.1    Huang, H.2    Ryan, J.3    Paul, W.E.4
  • 37
    • 0031569126 scopus 로고    scopus 로고
    • Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype
    • Nakamura, T., R.K. Lee, S.Y. Nam, E.R. Podack, K. Bottomly, and R.A. Flavell. 1997. Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype. J. Immunol. 158:2648-2653.
    • (1997) J. Immunol. , vol.158 , pp. 2648-2653
    • Nakamura, T.1    Lee, R.K.2    Nam, S.Y.3    Podack, E.R.4    Bottomly, K.5    Flavell, R.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.