Structural model for dihydropyridine binding to L-type calcium channels

Journal of Biological Chemistry

Volumn 284, Issue 28, 2009, Pages 19006-19017

  Tikhonov, Denis B ^a,b   Zhorov, Boris S ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION GATE; AGONISTIC ACTIVITY; AROMATIC MOIETIES; CALCIUM CHANNELS; CHANNEL CLOSING; CHANNEL OPENING; DESTABILIZING EFFECT; DIFFERENT MECHANISMS; DIHYDROPYRIDINE; DIHYDROPYRIDINES; H-BONDS; HYDROGEN ATOMS; HYDROPHILIC SUBSTITUENTS; LONG LASTING; MONTE CARLO; NH GROUPS; SELECTIVITY FILTER; SIDE CHAINS; SIX-MEMBERED RINGS; STRUCTURAL MODELS;

HYDROGEN; MODEL STRUCTURES;

CALCIUM;

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 1,4 DIHYDROPYRIDINE; 1,4 DIHYDROPYRIDINE DERIVATIVE; AMLODIPINE; BENIDIPINE; BK 10; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; GLUTAMIC ACID; GLUTAMINE; GS 120; GS 83; GS 87; HYDROGEN; LACIDIPINE; NIFEDIPINE; NIMODIPINE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM BINDING; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; LIGAND BINDING; MONTE CARLO METHOD; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; BINDING SITES; CALCIUM; CALCIUM CHANNELS, L-TYPE; DIHYDROPYRIDINES; HYDROGEN BONDING; IONS; LIGANDS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MONTE CARLO METHOD; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 67650523964     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.011296     Document Type: Article

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