Mechanism of Dihydropyridine Interaction with Critical Binding Residues of L-type Ca2+ Channel α1 Subunits

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 12730-12735

  Wappl, Edwin ^a   Mitterdorfer, Jörg ^a   Glossmann, Hartmut ^a   Striessnig, Jörg ^a  

^a A 6020   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; AROMATIC COMPOUNDS; DRUG THERAPY; ELECTRIC POTENTIAL; MUTAGENESIS; REACTION KINETICS;

ANTI-MIGRAINE THERAPEUTICS;

BIOCHEMISTRY;

AMIDE; ANTIMIGRAINE AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CARBONYL DERIVATIVE; DIHYDROPYRIDINE; ISOLEUCINE; METHIONINE; PHENYLALANINE; PROTEIN SUBUNIT; THREONINE; VALINE; 1,4 DIHYDROPYRIDINE; 1,4-DIHYDROPYRIDINE; ALANINE; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; ISRADIPINE; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GENE MUTATION; MIGRAINE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; STEREOCHEMISTRY; XENOPUS; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; KINETICS; METABOLISM; MOLECULAR GENETICS; OOCYTE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS;

ANIMALIA;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DIHYDROPYRIDINES; FEMALE; ISOLEUCINE; ISRADIPINE; KINETICS; METHIONINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PHENYLALANINE; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; VALINE; XENOPUS LAEVIS;

EID: 0035918277     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010164200     Document Type: Article

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