Molecular modeling of benzothiazepine binding in the L-type calcium channel

Journal of Biological Chemistry

Volumn 283, Issue 25, 2008, Pages 17594-17604

  Tikhonov, Denis B ^a,b   Zhorov, Boris S ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM COMPOUNDS; BINDING ENERGY; BINDING SITES; CALCIUM; FLOW INTERACTIONS; FUNCTIONAL GROUPS; THREE DIMENSIONAL;

ACTIVATION GATES; ALLOSTERIC MECHANISMS; AMMONIUM GROUPS; BINDING MODES; BULKY MOLECULES; CALCIUM CHANNELS; CARBONYL GROUPS; CHANNEL INTERACTIONS; CHANNEL MODELS; DO-MAINS; ELECTROSTATIC INTERACTIONS; ENERGY PROFILES; EXPERIMENTAL STUDIES; GLUTAMATE RESIDUES; MONTE CARLO; MUTATIONAL EXPERIMENTS; OPEN CHANNELS; PORE DOMAINS; SELECTIVITY FILTERS; THREE-DIMENSIONAL MODELS;

LIGANDS;

BENZOTHIAZEPINE DERIVATIVE; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL L TYPE 1.2; CALCIUM ION; CARBONYL DERIVATIVE; GLUTAMIC ACID; LIGAND; UNCLASSIFIED DRUG; 1,5 BENZOTHIAZEPINE; 1,5-BENZOTHIAZEPINE; BENZAZEPINE DERIVATIVE; CALCIUM; ION; SQ 32910; THIAZEPINE DERIVATIVE;

ARTICLE; BINDING SITE; ELECTRICITY; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; HUMAN; METABOLISM; PROTEIN CONFORMATION; THEORETICAL MODEL;

RUMEX;

ALLOSTERIC SITE; BENZAZEPINES; BINDING SITES; CALCIUM; CALCIUM CHANNELS, L-TYPE; ELECTROSTATICS; HUMANS; IONS; LIGANDS; MODELS, MOLECULAR; MODELS, THEORETICAL; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; THIAZEPINES;

EID: 47749155997     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800141200     Document Type: Article

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