Permanently charged chiral 1,4-dihydropyridines: Molecular probes of L- type calcium channels. Synthesis and pharmacological characterization of methyl (ω-trimethylalkylammonium) 1,4-dihydro-2,6-dimethyl-4-(3- nitrophenyl)-3,5-pyridinedicarboxylate iodide, calcium channel antagonists

Journal of Medicinal Chemistry

Volumn 43, Issue 15, 2000, Pages 2906-2914

  Peri, Ravikumar ^a,b   Padmanabhan, Seetharamaiyer ^a,c   Rutledge, Aleta ^a   Singh, Satpal ^a   Triggle, David J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b Rammelkamp Center for Education and Research   (United States)

^c CeNeS Pharmaceuticals plc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 1,4 DIHYDROPYRIDINE DERIVATIVE; 4 (2,1,3 BENZOOXADIAZOL 4 YL) 1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 3 PYRIDINECARBOXYLIC ACID ISOPROPYL ESTER; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; METHYL(OMEGA TRIMETHYLALKYLAMMONIUM)1,4 DIHYDRO 2,6 DIMETHYL 4 (3 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLATE IODIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CALCIUM CURRENT; CHIRALITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; ENANTIOMER; HUMAN; HUMAN CELL; NONHUMAN; RAT;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; CEREBRAL CORTEX; DIHYDROPYRIDINES; MEMBRANE POTENTIALS; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; PITUITARY GLAND; RADIOLIGAND ASSAY; RATS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034721160     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000028l     Document Type: Article

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