Molecular mechanisms of homocysteine toxicity

Biochemistry (Moscow)

Volumn 74, Issue 6, 2009, Pages 589-598

  Boldyrev, A A ^a,b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b RESEARCH CENTER OF NEUROLOGY   (Russian Federation)

Author keywords

Homocysteic acid; Homocysteine; Lymphocytes; Neurons; Neutrophils; NMDA receptors

Indexed keywords

LYMPHOCYTES; NEURONS; TISSUE;

FUNCTIONAL ACTIVITIES; HOMOCYSTEIC ACID; HOMOCYSTEINES; HYPERHOMOCYSTEINEMIA; INTRACELLULAR LEVELS; NEUTROPHILS; NMDA RECEPTOR; SHORT-TERM EXPOSURE;

TOXICITY;

RATTUS;

CARNOSINE; DRUG DERIVATIVE; HOMOCYSTEIC ACID; HOMOCYSTEINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL; APOPTOSIS; BLOOD; BLOOD CELL; CARDIOVASCULAR DISEASE; DEGENERATIVE DISEASE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENETICS; HUMAN; HYPERHOMOCYSTEINEMIA; MALE; METABOLISM; NERVE CELL; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; REVIEW; RISK FACTOR;

ANIMALS; APOPTOSIS; BLOOD CELLS; CARDIOVASCULAR DISEASES; CARNOSINE; FEMALE; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; NEURODEGENERATIVE DISEASES; NEURONS; PREGNANCY; RECEPTORS, N-METHYL-D-ASPARTATE; RISK FACTORS;

EID: 67650077224     PISSN: 00062979     EISSN: 16083040     Source Type: Journal    
DOI: 10.1134/S0006297909060017     Document Type: Review

References (83)

1. M. Arnadottir B. Hultberg V. Vladov P. Nilsson-Ehle H. Thysell 1996 Transplantation 61 509 512
2. O. P. Shevchenko 2004 Klin. Lab. Diagn. 10 25 31
3. P. F. Jacques 1999 New Engl. J. Med. 340 1449 1454
4. G. Welch J. Loscalo 1998 New Engl. J. Med. 338 1042 1050
5. C. J. Warren 2002 Progr. Cardiovasc. Nurs. 17 35 41
6. D. Genser 2004 Cardiovasc. Rev. Rep. 24 253 258
7. H. McNulty K. Pentieva L. Hoey M. Ward 2008 Proc. Nutr. Soc. 67 232 237
8. M. Leeda 1998 Am. J. Obstet. Gynecol. 179 135 139
9. M. Lopez-Torres G. Barja 2008 Rev. Geriatr. Gerontol. 43 252
10. J. H. Stein M. Bushara K. Bushara P. E. McBride D. E. Jorenby M. C. Fiore 2002 Clin. Cardiol. 25 23 26
11. M. Grubben 1997 Am. J. Clin. Nutr. 71 480 484
12. K. McCully 1993 Atherogen. Anal. Clin. Lab. Sci. 23 477 493
13. M. Graham 1997 J. Am. Med. Assoc. 277 1775 1781
14. J. Stein P. McBride 1998 Arch. Int. Med. 158 1301 1306
15. E. Mayer 1996 J. Am. Coll. Cardiol. 27 517 527
16. J. Thambyrajah J. N. Townend 2002 Neuron Heart 21 967 974
17. M. J. Stampfer M. R. Malinow W. C. Willett L. M. Newcomer B. Upson D. Ullmann P. V. Tishler C. H. Hennekens 1992 J. Am. Med. Assoc. 268 877 881
18. I. J. Perry H. Refsum R. W. Morris S. B. Ebrahim P. M. Ueland A. G. Shaper 1995 Br. Med. Lancet 346 1395 1398
19. T. Demir A. Comlekci O. Demir A. Gulcu S. Caliskan L. Argun M. Secil S. Yesil A. Esen 2008 J. Diabetes Complications 22 395 399
20. S. Seshadri A. Beiser J. Selhub P. F. Jacques I. H. Rosenberg R. B. D'Agostino P. W. F. Wilson P. A. Wolf 2002 N. Engl. J. Med. 346 476 483
21. J. C. Watkins D. E. Jane 2006 Br. J. Pharmacol. 147 100 108
22. M. Van den Berg M. S. van der Knaap G. H. Boers C. D. Stehouwer J. A. Rauwerda J. Valk 1995 Neuroradiology 37 403 411
23. B. Fowler 2005 Ther. Umsch. 62 641 646
24. L. M. Joubert M. M. Manore 2006 Int. J. Sport. Nutr. Exerc. Metab. 16 341 361
25. S. Ramakrishnan K. N. Sulochana S. Lakshmi R. Selvi N. Angayarkanni 2006 Indian J. Biochem. Biophys. 43 275 283
26. S. Asfar H. A. Safar 2007 J. Cardiovasc. Surg. 48 601 605
27. N. W. Shammas E. J. Dippel M. Jerin P. P. Toth M. Kapalis M. Reddy H. Harb 2008 Prev. Cardiol. 11 95 99
28. A. A. Boldyrev P. Johnson 2007 J. Alz. Dis. 11 219 228
29. W. K. Kim Y. S. Pae 1996 Neurosci. Lett. 216 117 120
30. S. A. Lipton W. K. Kim Y. B. Choi S. Kumar D. M. D'Emilia P. V. Rayudu D. R. Arnelle J. S. Stamler 1997 Proc. Natl. Acad. Sci. USA 94 5923 5928
31. Q. Shi J. E. Savage S. J. Hufeisen L. Rauser E. Grajkowska P. Ernsberger J. T. Wroblewski J. H. Nadeau B. L. Roth 2003 J. Pharmacol. Exp. Ther. 305 131 142
32. A. A. Boldyrev E. R. Bulygina A. V. Makhro 2004 Neurotox. Res. 6 581 587
33. A. V. Makhro E. R. Bulygina A. A. Boldyrev 2006 Neirokhimiya 23 140 145
34. E. Zieminska A. Stafiej J. W. Lazarewicz 2003 Neurochem. Int. 43 481 492
35. Ph. Gortz A. Hoinke W. Fleischer F. Otto B. Schwahn U. Wendel M. J. Siebler 2004 Neurol. Sci. 218 109 114
36. A. A. Boldyrev 2005 Byul. Eksp. Biol. Med. 140 39 44
37. A. A. Boldyrev 2006 Neirokhimiya 23 165 172
38. J. Folbergrova R. Haugvicova P. Mares 2000 Exp. Neurol. 161 336 345
39. A. A. Boldyrev D. O. Carpenter P. Johnson 2005 J. Neurochem. 95 913 918
40. E. Tuneva O. Bychkova A. Boldyrev 2003 Byul. Eksp. Biol. Med. 136 184 186
41. A. A. Boldyrev V. I. Kazey T. A. Leinsoo A. P. Mashkina O. V. Tyulina P. Johnson J. O. Tuneva S. Chittur D. O. Carpenter 2004 Biochem. Biophys. Res. Commun. 324 133 139
42. G. Lombardi C. Dianzani G. Miglio P. L. Canonico R. Fantozzi 2001 Br. J. Pharmacol. 133 936 944
43. A. P. Mashkina O. V. Tyulina T. I. Solovyova E. I. Kovalenko L. M. Kanevski P. Johnson A. A. Boldyrev 2007 Neurochem. Int. 51 356 360
44. G. Miglio F. Varsaldi G. Lombardi 2005 Biochem. Biophys. Res. Commun. 338 1875 1882
45. Mashkina, A., personal communication.
46. A. A. Boldyrev E. R. Bulygina D. Carpenter W. Schoner 2003 J. Mol. Neurochem. 21 213 222
47. L. Bazzichi L. Trincavelli A. Rossi F. de Feo A. Lucacchini S. Bombardieri C. Martini 2005 Arthritis Res. Ther. 7 189 195
48. B. N. Cronstein 1994 J. Appl. Physiol. 76 5 13
49. A. Asahi T. Nishimoto Y. Okazaki H. Suzuki T. Masaoka Y. Kawakami Y. Ikeda M. Kuwana 2008 J. Clin. Invest. 118 2939 2949
50. J. E. Salmon B. N. Cronstein 1990 J. Immunol. 145 2235 2240
51. A. De Mendonca A. M. Sebastiao J. A. Ribeiro 1995 Neuroreport 30 1097 1100
52. B. B. Fredholm A. P. Jzerman K. A. Jacobson K.-N. Klotz J. Linden 2001 Pharmacol. Rev. 53 527 552
53. Byushkova, E. A. (2008) in Materials of Int. Conf. Lomonosov-2008, Moscow, pp. 32-33.
54. P. G. Genever D. Wilkinson A. Patton N. Peet Y. Hong A. Mathur J. Erusalimsky T. Skerry 1999 Blood 93 2876 2883
55. D. Miao S. Murant N. Scutt P. Genever A. Scutt 2004 Tissue Engin. 10 807 810
56. Karpova, L., Bryushkova, E., Makhro, A., Mashkina, A., Bulygina, E., Vladychenskaya, E., Stepanova, M., Fedorova, T., and Boldyrev, A. (2008) in Abstract Book of Ehrlich 2nd World Conf. on Magic Bullets, Germany, A-151.
57. E. A. Vladychenskaya O. V. Tyulina A. A. Boldyrev 2006 Byul. Eksp. Biol. Med. 142 47 50
58. V. N. Maltseva N. V. Avkhacheva B. F. Santalov V. G. Safronova 2006 Tsitologiya 48 1000 1009
59. A. A. Ivanov I. I. Baskin V. A. Palyulin N. S. Zefirov 2002 Dokl. RAN (Ser. Biokhim. Biofiz.) 386 271 274
60. E. A. Vladychenskaya A. A. Boldyrev 2009 Neirokhimiya 26 72 78
61. Vladychenskaya, E., Urano, S., and Boldyrev, A. (2008) in Int. Conf. on Lipid Peroxidation, Japan, 2008, P-16, p. 105.
62. E. S. Arzumanyan A. V. Makhro O. V. Tyulina A. A. Boldyrev 2008 Dokl. RAN (Ser. Biokhim. Biofiz.) 418 44 46
63. W. Fu N. Dudman M. A. Perry X. L. Wang 2002 Atherosclerosis 161 169 176
64. B. Kuch M. Bobak M. Fobker R. Junker A. von Eckardstein M. Marmot H. W. Hense 2001 Thromb. Res. 103 265 273
65. J. Loscalo 1996 J. Clin. Invest. 98 5 7
66. S. E. Vollset H. Refsum L. M. Irgens B. M. Emblem A. Tverdal H. K. Gjessing A. L. Monsen P. M. Ueland 2000 Am. J. Clin. Nutr. 71 962 968
67. M. J. Kupfermine N. Steinman A. Eldor 1998 Soc. Gynecol. Invest. 5 137A
68. Johnston, C. Smoking in Pregnancy Places Fetus at Risk for Neural Tube Defects, http://www.pslgroup.com/dg/212EF6.htm
69. Boldyrev, A., and Johnson, P. (2002) in Oxidative Stress at Molecular, Cellular and Organ Levels (Johnson, P., and Boldyrev, A., eds.) pp. 101-113.
70. Boldyrev, A. A. (2007) Carnosine and Protection of Cells and Tissues from Oxidative Stress, N.-Y.
71. A. A. Boldyrev S. L. Stvolinsky O. V. Tyulina V. B. Koshelev N. Hori D. Carpenter 1997 Cell. Molec. Neurobiol. 17 259 271
72. A. A. Boldyrev R. Song D. Lawrence D. O. Carpenter 1999 Neuroscience 94 571 577
73. A. A. Boldyrev S. E. Severin 1990 Adv. Enz. Regul. 30 174 193
74. P. Hyland O. Duggan A. Hipkiss C. Barnett Y. Barnett 2000 Mech. Ageing Devel. 121 203 215
75. A. Boldyrev 2005 Ann. N. Y. Acad. Sci. 1057 193 205
76. A. Pegova H. Abe A. Boldyrev 2000 Comp. Biochem. Physiol. 127B 443 446
77. A. Hipkiss 2007 J. Alz. Dis. 11 229 240
78. Fedorova, T. N., Stvolinsky, S. L., Dobrota, D., and Boldyrev, A. A. (2002) Vopr. Biol. Med. Farm. Khim., No. 1, 41-44.
79. Q. Fu H. Dai W. Hu Y. Fan Y. Shen W. Zhang Z. Chen 2008 Cell. Molec. Neurobiol. 28 307 316
80. G. Baydas S. Koz M. Tuzcu V. Nedzvetsky E. Etem 2007 Int. J. Devel. Neurosci. 25 133 139
81. A. V. Makhro A. P. Mashkina O. A. Solenaya O. A. Trunova O. D. Tyulina E. R. Bulygina A. A. Boldyrev 2008 Neirokhimiya 25 233 240
82. R. G. M. Morris P. Garrud J. N. Rawlins J. O'Keefe 1982 Nature 297 681 683
83. A. A. Boldyrev E. O. Tuneva 2005 Biol. Membr. (Moscow) 22 147 150