Hyperhomocysteinemia in cyclosporine-treated renal transplant recipients

Transplantation

Volumn 61, Issue 3, 1996, Pages 509-512

  Arnadottir, Margret ^a,b   Hultberg, Björn ^a   Vladov, Vladimir ^a   Nilsson Ehle, Peter ^a   Thysell, Hans ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORONARY RISK; FEMALE; GLOMERULUS FILTRATION RATE; HOMOCYSTINURIA; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FAILURE; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGED; ARTERIOSCLEROSIS; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; CYCLOSPORINE; ERYTHROCYTES; FEMALE; FOLIC ACID; GLOMERULAR FILTRATION RATE; HOMOCYSTEINE; HOMOCYSTINURIA; HUMANS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; RISK FACTORS;

EID: 0030023332     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199602150-00034     Document Type: Article

References (24)

1. McCully KS. Homocysteine theory of arteriosclerosis: development and current status. Atheroscler Rev 1983; 11: 157.
2. Clarke R, Daly L, Robinsson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991; 324: 1149.
3. Ueland PM, Refsum H, Brattström L. Plasma homocysteine and cardiovascular disease. In: Francis RB Jr, ed. Atherosclerotic cardiovascular disease, hemostasis, and endothelial function. New York: Marcel Dekker, 1992: 183.
4. Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA 1992; 268: 877.
5. Selhub J, Jacques PF, Bostom AG, et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med 1995; 332: 286.
6. Gunnarsson R, Löfmark R, Nordlander R, Nyquist O, Groth CG. Acute myocardial infarction in renal transplant recipients. Eur Heart J 1984; 5: 218.
7. Raine AEG, Margreiter R, Brunner FP, et al. Report on management of renal failure in Europe, XXII, 1991. Nephrol Dial Transplant 1992; 7 (suppl 2): 7.
8. Chapman JR, Marcen R, Ariaz M, Raine AEG, Dunnill MS, Morris PJ. Hypertension after renal transplantation: a comparison of cyclosporine and conventional immunosuppression. Transplantation 1987; 43: 860.
9. Kasiske BL, Umen AJ. Persistent hyperlipidemia in renal transplant patients. Medicine (Baltimore) 1987; 66: 309.
10. Öst L, Tydén G, Fehrman I. Impaired glucose tolerance in cyclosporine-prednisolone-treated renal graft recipients. Transplantation 1988; 46: 370.
11. Wilcken DEL, Gupta VJ, Betts AK. Homocysteine in the plasma of renal transplant recipients: effects of cofactors for methionine metabolism. Clin Sci 1981; 61: 743.
12. Massy ZA, Chadefaux-Vekemans B, Chevalier A, et al. Hyperhomocysteinaemia: a significant risk factor for cardiovascular disease in renal transplant recipients. Nephrol Dial Transplant 1994; 9: 1103.
13. Krützén E, Bäck SE, Nilsson-Ehle I, Nilsson-Ehle P. Plasma clearance of a new contrast agent, iohexol: a method for the assessment of glomerular filtration rate. J Lab Clin Med 1984; 104: 955.
14. 51Cr-EDTA. Scand J Clin Lab Invest 1969; 23: 301.
15. Andersson A, Isaksson A, Brattström L, Hultberg B. Determination of homocysteine and other thiols in human plasma by high-performance liquid chromatography and a thiol-specific postcolumn derivatization procedure. Clin Chem 1993; 39: 1590.
16. Wilcken DEL, Gupta VJ. Sulphur containing amino acids in chronic renal failure with particular reference to homocystine and cysteine-homocysteine mixed disulphide. Eur J Clin Invest 1979; 9: 301.
17. Chauveau P, Chadefaux B, Coudé M, et al. Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients. Kidney Int 1993; 43: S72.
18. Maurer G, Loosli HR, Schreier E, Keller B. Disposition of cyclosporine in several animal species and man. Drug Metab Dispos 1984; 12: 120.
19. Israelsson B, Brattström LE, Hultberg BL. Homocysteine and myocardial infarction. Atherosclerosis 1988; 71: 227.
20. Brattström L, Israelsson B, Jeppsson JO, Hultberg B. Folic acid - an innocuous means of reducing plasma homocysteine. Scand J Clin Lab Invest 1988; 48: 215.
21. Wilcken DEL, Dudman NPB, Tyrrell PA, Robertson MR. Folic acid lowers elevated plasma homocysteine in chronic renal insufficiency: possible implications for prevention of vascular disease. Metabolism 1988; 37: 697.
22. Arnadottir M, Brattström L, Simonsen O, et al. The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine concentrations in dialysis patients. Clin Nephrol 1993; 40: 236.
23. Hultberg B, Andersson A, Sterner G. Plasma homocysteine in renal failure. Clin Nephrol 1993; 40: 230.
24. Bostom A, Brosnan JT, Hall B, Nadeau MR, Selhub J. Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis (in press).