Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: The Hordaland Homocysteine Study

American Journal of Clinical Nutrition

Volumn 71, Issue 4, 2000, Pages 962-968

  Vollset, Stein Emil ^a   Refsum, Helga ^b   Irgens, Lorentz M ^b   Emblem, Barbro Mork ^b   Tverdal, Aage ^b   Gjessing, Håkon K ^b   Monsen, Anne Lise Bjørke ^b   Ueland, Per Magne ^b  

^a UNIVERSITY OF BERGEN   (Norway)

^b NONE

Author keywords

Abruptio placentae; Congenital malformations; Folate; Neural tube defects; Norway; Observational study; Placental abruptio; Preeclampsia; Pregnancy complications; tHcy; The Hordaland Homocysteine Study; Total homocysteine; Whites

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CLUBFOOT; CONGENITAL MALFORMATION; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; NEURAL TUBE DEFECT; OUTCOMES RESEARCH; PREECLAMPSIA; PREGNANCY COMPLICATION; PREMATURITY; RISK FACTOR; SOLUTIO PLACENTAE; VERY LOW BIRTH WEIGHT;

PIERINAE;

EID: 0034073977     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/71.4.962     Document Type: Article

References (47)

1. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-7.
2. Czeizel AE, Dudas I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832-5.
3. Czeizel AE. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. BMJ 1993;306:1645-8.
4. Shaw GM, Lammer EJ, Wasserman CR, O'Malley CD, Tolarova MM. Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet 1995; 346: 393-6.
5. Botto LD, Khoury MJ, Mulinare J, Erickson JD. Periconceptional multivitamin use and the occurrence of conotruncal heart defects: results from a population-based, case-control study. Pediatrics 1996;98:911-7.
6. Li DK, Daling JR, Mueller BA, Hickok DE, Fantel AG, Weiss NS. Periconceptional multivitamin use in relation to the risk of congenital urinary tract anomalies. Epidemiology 1995;6:212-8.
7. Shaw GM, O'Malley CD, Wasserman CR, Tolarova MM, Lammer EJ. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart detects and limb deficiencies among offspring. Am J Med Genet 1995;59:536-45.
8. Yang Q, Khoury MJ, Olney RS, Mulinare J. Does periconceptional multivitamin use reduce the risk for limb deficiency in offspring? Epidemiology 1997;8:157-61.
9. Scholl TO, Hediger ML, Bendich A, Schall JI, Smith WK, Krueger PM. Use of multivitamin/mineral prenatal supplements: influence on the outcome of pregnancy. Am J Epidemiol 1997; 146:134-41.
10. Fawzi WW, Msamanga GI, Spiegelman D, et al. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 1998; 351:1477-82.
11. Refsum H, Ueland PM, Nygård O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med 1998;49:31-62.
12. Green R, Miller JW. Folate deficiency beyond megaloblastic anemia: hyperhomocysteinemia and other manifestations of dysfunctional folate status. Semin Hematol 1999;36:47-64.
13. Brouwer DA, Welten HT, Reijngoud DJ, van Doormaal JJ, Muskiet FA. Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine. Clin Chem 1998;44:1545-50.
14. Mills JL, McPartlin JM, Kirke PN, et al. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 1995; 345:149-51.
15. Bjørke-Monsen AL, Ueland PM, Schneede J, Vollset SE, Refsum H. Elevated plasma total homocysteine and C677T mutation of the methylenetetra-hydrofolate reductase gene in patients with spina bifida. Q J Med 1997;90:593-6.
16. Burke G, Robinson K, Refsum H, Stuart B, Drumm J, Graham I. Intrauterine growth retardation, perinatal death, and maternal homocysteine levels. N Engl J Med 1992;326:69-70 (letter).
17. Steegers-Theunissen RP, Boers GH, Blom HJ, Trijbels FJ, Eskes TK. Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet 1992;339:1122-3 (letter).
18. Wouters MG, Boers GH, Blom HJ, et al. Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Steril 1993;60:820-5.
19. Dekker GA, de Vries JI, Doelitzsch PM, et al. Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol 1995;173:1042-8.
20. Goddijn Wessel TAW, Wouters MGAJ, van der Molen EF, et al. Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Eur J Obstet Gynecol Reprod Biol 1996;66: 23-9.
21. Finnell RH, Greer KA, Barber RC, Piedrahita JA, Shaw GM, Lammer EJ. Neural tube and craniofacial defects with special emphasis on folate pathway genes. Crit Rev Oral Biol Med 1998;9: 38-53.
22. Nygård O, Vollset SE, Refsum H, et al. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA 1995;274:1526-33.
23. Refsum H, Ueland PM, Svardal AM. Fully automated fluorescence assay for determining total homocysteine in plasma. Clin Chem 1989;35:1921-7.
24. Fiskerstrand T, Refsum H, Kvalheim G, Ueland PM. Homocysteine and other thiols in plasma and urine: automated determination and sample stability. Clin Chem 1993;39:263-71.
25. Central Bureau of Statistics. Standard for classification of diseases, injuries, and causes of death. Norwegian adaptation of the WHO's 8th revision of the international classification of diseases. Oslo: Central Bureau of Statistics, 1973.
26. Medical Birth Registry of Norway 1967-1996. Births in Norway through 30 years. Bergen, Norway: Medical Birth Registry of Norway, 1997.
27. Zeger SL, Liang KY. Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986;42:121-30.
28. Bjerkedal T, Skjærven R. Percentiles of birth weight and crown-heel length in relation to gestation period for single live births. Tidsskr Nor Lægeforen 1980;100:1088-91 (in Norwegian).
29. Nygard O, Refsum H, Ueland PM, Vollset SE. Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study. Am J Clin Nutr 1998;67:263-70.
30. Hibbard BM, Hibbard ED, Hwa TS, Tan P. Abruptio placentae and defective folate metabolism in Singapore women. J Obstet Gynaecol Br Commonw 1969;76:1003-7.
31. Alperin JB, Haggard ME, McGanity WJ. Folic acid, pregnancy, and abruptio placentae. Am J Clin Nutr 1969;22:1354-61.
32. Hall MH. Folic acid deficiency and abruptio placentae. J Obstet Gynaecol Br Commonw 1972;79:222-5.
33. Neggers YH, Goldenberg RL, Tamura T, Cliver SP, Hoffman HJ. The relationship between maternal dietary intake and infant birth-weight. Acta Obstet Gynecol Scand 1997;76:71-5.
34. Tamura T, Goldenberg RL, Johnston KE, Cliver SP, Hoffman HJ. Serum concentrations of zinc, folate, vitamins A and E, and proteins, and their relationships to pregnancy outcome. Acta Obstet Gynecol Scand 1997;76:63-70.
35. Guttormsen AB, Ueland PM, Nesthus I, et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/L). The Hordaland Homocysteine Study. J Clin Invest 1996;98:2174-83.
36. van der Put NM, Steegers Theunissen RP, Frosst P, et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spi≥na bifida. Lancet 1995;346:1070-1.
37. Whitehead AS, Gallagher P, Mills JL, et al. A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. Q J Med 1995;88:763-6.
38. Ou CY, Stevenson RE, Brown VK, et al. 5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects. Am J Med Gen 1996;63:610-4.
39. Sohda S, Arinami T, Hamada H, Yamada N, Hamaguchi H, Kubo T. Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J Med Genet 1997;34:525-6.
40. Grandone E, Margaglione M, Colaizzo D, et al. Factor V Leiden, C>T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost 1997;77:1052-4.
41. Nelen WL, Steegers EA, Eskes TK, Blom HJ. Genetic risk factor for unexplained recurrent pregnancy loss. Lancet 1997;350:861 (letter).
42. Nygård O, Refsum H, Ueland PM, et al. Coffee consumption and total plasma homocysteine: The Hordaland Homocysteine Study. Am J Clin Nutr 1997;65:136-43.
43. Locksmith GJ, Duff P. Preventing neural tube defects: the importance of periconceptional folic acid supplements. Obstet Gynecol 1998;91:1027-34.
44. Lentz SR. Mechanisms of thrombosis in hyperhomocysteinemia. Curr Opin Hematol 1998;5:343-9.
45. Clarke R, Woodhouse P, Ulvik A, et al. Variability and determinants of total homocysteine concentrations in plasma in an elderly population. Clin Chem 1998;44:102-7.
46. Andersson A, Hultberg B, Brattstrom L, Isaksson A. Decreased serum homocysteine in pregnancy. Eur J Chem Clin Biochem 1992;30:377-9.
47. Bonnette RE, Caudill MA, Boddie AM, Hutson AD, Kauwell GP, Bailey LB. Plasma homocyst(e)ine concentrations in pregnant and nonpregnant women with controlled folate intake. Obstet Gynecol 1998;92:167-70.