Protection of proteins from oxidative stress: A new illusion or a novel strategy?

Annals of the New York Academy of Sciences

Volumn 1057, Issue , 2005, Pages 193-205

  Boldyrev, Alexander A ^a,b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b Department of Biochemistry   (Russian Federation)

Author keywords

Carnosine; Glycation; Oxidative stress; Protein carbonyls

Indexed keywords

2 ISOPROPYLIDENEHYDRAZONO 4 OXO 5 THIAZOLIDINYLACETANILIDE; ADVANCED GLYCATION END PRODUCT; AMINOGUANIDINE; ANTIOXIDANT; CARBOHYDRATE; CARNOSINE; GLYCOSYLATED PROTEIN; LIPID; MELATONIN; PROTECTIVE AGENT; PROTEIN; PROTEIN DERIVATIVE; PYRIDOXAMINE; TENILSETAM; THIOCTIC ACID; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; HYDROPHILICITY; HYDROPHOBICITY; LIFESPAN; LIPID PEROXIDATION; METABOLISM; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN MODIFICATION;

ANIMALIA;

EID: 32244432726     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1356.013     Document Type: Conference Paper

References (42)

1. BOLDYREV, A.A. 2002. Significance of reactive oxygen species for neuronal function. In Free Radicals, Nitric Oxide, and Inflammation: Molecular, Biochemical, and Clinical Aspects. A. Tomasi, T. Ozben & V. Skulachev, Eds.: 153-169. IOS Press. Amsterdam.
2. LUBEC, B., J. GOLEJ, M. MARX, et al. 1995. L-Arginine reduces kidney lipid peroxidation, glycoxidation, and collagen accumulation in the aging NMRI mouse. Ren. Physiol. Biochem. 18: 97-102.
3. GUTTERIDGE, J.M. 1999. Does red/ox regulation of cell function explain why antioxidants perform so poorly as therapeutic agents? Redox Rep. 4: 129-131.
4. WEBSTER, J., C. URBAN, K. BERBAUM, et al. 2005. The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal. Neurotox. Res. 7: 95-101.
5. DUKIC-STEFANOVIC, S, R. SCHINZEL, P. RIEDERER & G. MUNCH. 2001. AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs? Biogerontology 2: 19-34.
6. GULEVITCH, V. & S. AMIRADGIBI. 1900. Uber das carnosine, eine neue organische base des fleischextraktes. Ber. Deutsch. Chem. Gesellschaft. 33: 15504-15509.
7. BOLDYREV, A.A. & S.E. SEVERIN. 1990. The histidine-containing dipeptides, carnosine, and anserine: distribution, properties, and biological significance. Adv. Enz. Reg. 30: 175-193.
8. BOLDYREV A.A. 1990. Retrospectives and perspectives on the biological activity of histidine-containing dipeptides. Int. J. Biochem. 22: 129-132.
9. ABE, H. 2000. Role of histidine-related compounds as intracellular proton buffering constituents in vertebrate muscle. Biochemistry (Mosc.) 65: 757-765.
10. BOLDYREV, A. 2002. Carnosine as natural antioxidant and neuroprotector: biological functions and possible clinical use. In Free Radicals, Nitric Oxide, and Inflammation: Molecular, Biochemical, and Clinical Aspects. A. Tomasi, T. Ozben & V. Skulachev, Eds.: 202-217. IOS Press. Amsterdam.
11. HIPKISS, A., V. WORTHINGTON, D. HIMSWORTH & W. HERWIG. 1998. Protective effect of carnosine against protein modification mediated by malondialdehyde and hypochlorite. Biochim. Biophys. Acta 1380: 46-54.
12. HIPKISS, A. & C. BROWNSON. 2000. Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageing peptide? Biogerontology 1: 217-223.
13. KULEVA, N.V. & Z.S. KOVALENKO. 1997. Change in the functional properties of actin by its glycation in vitro. Biochem. Moscow 62: 1119-1123.
14. HYLAND, P, O. DUGGAN, A. HIPKISS, et al. 2000. The effects of carnosine on oxidative DNA damage levels and in vitro lifespan in human peripheral blood derived CD4+T cell clones. Mech. Ageing Dev. 121: 203-215.
15. DUPIN, A., A. BOLDYREV, Y. ARKHIPENLO & V. KAGAN. 1984. Carnosine protection of Ca transport from damage induced by lipid peroxidation. Biul. Exp. Biol. Med. 97: 186-188.
16. ARUOMA, O., M. LAUGHTON & B. HALLIWELL. 1989. Carnosine, homocarnosine, and anserine: could they act as anti-oxidants in vivo? Biochem. J. 264: 863-869.
17. HARTMAN, P.E., Z. HARTMAN & K.T. AULT. 1990. Scavenging of singlet molecular oxygen by imidazole compounds: high and sustained activities of carboxy terminal histidine dipeptides and exceptional activity of imidazole-4-acetic acid. Photochem. Photobiol. 51: 59-66.
18. RUBTSOV, A.M., M. SCHARA, M. SENTJURC & A. BOLDYREV. 1991. Hydroxyl radical-scavenging activity of carnosine: a spin trapping study. Acta Pharm. Jugosl. 41: 401-407.
19. PAVLOV, A., A. REVINA, A. DUPIN, et al. 1993. The mechanism of interaction of carnosine with Superoxide radicals in water solutions. Biochim. Biophys. Acta 1157: 304-312.
20. ALDINI, G., M. CARINI, G. BERETTA, et al. 2002. Carnosine as a quencher of 4-hydroxynonenal: through what mechanism of reaction? Biochem. Biophys. Res. Commun. 298: 699-706.
21. LIU, Y., G. Xu & M. SAYRE. 2003. Carnosine inhibits (E)-4-hydroxy-2-nonenal-induced protein cross-linking: structural characterization of carnosine-HNE adducts. Chem. Res. Toxicol. 16: 1589-1597.
22. UKEDA, H., Y. HASEGAWA, Y. HARADA & M. SAWAMURA. 2002. Effect of carnosine and related compounds on the inactivation of human Cu,Zn-superoxide dismutase by modification of fructose and glycolaldehyde. Biosci. Biotechnol. Biochem. 66: 36-43.
23. STVOLINSKY, S., T. FEDOROVA, M. YUNEVA & A. BOLDYREV. 2003. Protection of Cu/Zn-SOD by carnosine under disordering of brain metabolism in vivo. Biul. Exp. Biol. Med. 135: 151-154.
24. SHAO, L., Q.H. LI & Z. TAN. 2004. L-Carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem. Biophys. Res. Commun. 324: 931-936.
25. YUNEVA, M., E. BULYGINA, S. GALLANT, et al. 1999. Effect of carnosine on age-induced changes in senescence accelerated mice (SAM). J. Anti-Aging Med. 2: 337-342.
26. BERSTEIN, L., E. TSIRLINA, T. POROSHINA, et al. 2003. Induction of the phenomenon of switching off estrogen effect and approaches to its removal. Russian Physiol. J. 89: 964-971.
27. QUINN, P., A. BOLDYREV & V. FORMAZYUK. 1992. Carnosine: its properties, functions, and potential therapeutical applications. Mol. Aspects Med. 13: 379-444.
28. YAN, H. & J.J. HARDING. 2005. Carnosine protects against the inactivation of esterase induced by glycation and a steroid. Biochim. Biophys. Acta 1741: 120-126.
29. McFARLAND, G.A. & R. HOLLIDAY. 1994. Retardation of senescence in cultured human diploid fibroblasts by carnosine. Exp. Cell Res. 212: 167-175.
30. BROWNSON, C. & A. HIPKISS. 2000. Carnosine reacts with a glycated protein. Free Rad. Biol. Med. 28: 1564-1570.
31. HOBART, L., I. SEIBEL, G. YEARGANS & N. SEIDLER. 2004. Anticross-linking properties of carnosine: significance of histidine. Life Sci. 75: 1379-1389.
32. YEARGANS, G. & N. SEIDLER. 2003. Carnosine promotes the heat denaturation of glycated protein. Biochem. Biophys. Res. Commun. 300: 75-80.
33. SEIDLER, N., G. YEARGANS & T. MORGAN. 2004. Carnosine disaggregates glycated α-cristallin: an in vitro study. Arch. Biochem. Biophys. 427: 110-115.
34. BOLDYREV, A., M. YUNEVA, E. SOROKINA, et al. 2001. Antioxidant systems in tissues of senescence accelerated mice (SAM). Biochem. Moscow 66: 1157-1163.
35. YUNEVA, A.O., G.G. KRAMARENKO, T.V. VETRESHCHAK, et al. 2002. Effect of carnosine on Drosophila melanogaster lifespan. Biul. Exp. Biol. Med. 133: 559-561.
36. SZWERGOLD, B.S. 2005. Intrinsic toxicity of glucose, due to nonenzymatic glycation, is controlled in vivo by deglycation systems including FN3K-mediated deglycation of fructosamines and transglycation of aldosamines. Med. Hypotheses 65: 337-348.
37. HIPKISS, A.R. 2005. Glycation, aging, and carnosine: are carnivorous diets beneficial? Mech. Ageing Dev. 126: 1034-1039.
38. STVOLINSKY, S., M. KUKLEY, D. DOBROTA, et al. 2000. Carnosine protects rats under global ischemia. Brain Res. Bull. 53: 445-448.
39. FEDOROVA, T.N., S.L. STVOLINSKY, D. DOBROTA & A.A. BOLDYREV. 2002. Therapeutic effect of carnosine under experimental brain ischemia. Prob. Biol Med. Pharmacol. Chem. 1: 41-44.
40. FUJII, T., M. TAKAOKA, T. MURAOKA, et al. 2003. Preventive effect of L-carnosine on ischemia/reperfusion-induced acute renal failure in rats. Eur. J. Pharmacol. 474: 261-267.
41. ZHOU, H., F. SHEN & A. WANG. 2003. The oxidative carbonyl protein and carnosine protection. Chin. J. Gerontol. 5: 310-312.
42. WANG, A., C. MA, Z. XIE & F. SHEN. 2000. Use of carnosine as a natural antisenescence drug for human beings. Biochem. Moscow 65: 869-871.