Implications for hyperhomocysteinemia: Not homocysteine but its oxidized forms strongly inhibit neuronal network activity

Journal of the Neurological Sciences

Volumn 218, Issue 1-2, 2004, Pages 109-114

  Görtz, Philipp ^a   Hoinkes, Annika ^a   Fleischer, Wiebke ^a   Otto, Frauke ^a   Schwahn, Bernd ^a   Wendel, Udo ^a   Siebler, Mario ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Dementia; Homocysteic acid; Homocysteine; Homocysteinesulfinic acid; Homocystinuria; Microelectrode array; Neuronal network activity; NMDA

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; HOMOCYSTEIC ACID; HOMOCYSTEINE; HOMOCYSTEINE SULFINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; EMBRYO; HYPERHOMOCYSTEINEMIA; INHIBITION KINETICS; MICROELECTRODE; NERVE CELL DEGENERATION; NERVE CELL NETWORK; NONHUMAN; OXIDATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RAT STRAIN;

EID: 0842305029     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2003.11.009     Document Type: Article

References (31)

1. Seshadri S., Beiser A., Selhub J., Jacques P.F., Rosenberg I.H., D'Agostino R.B.et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N. Engl. J. Med. 346(7):2002;476-483.
2. Refsum H., Ueland P.M. Clinical significance of pharmacological modulation of homocysteine metabolism. Trends Pharmacol. Sci. 11(10):1990;411-416.
3. Diaz-Arrastia R. Homocysteine and neurologic disease. Arch. Neurol. 57(10):2000;1422-1427.
4. Clarke R., Smith A.D., Jobst K.A., Refsum H., Sutton L., Ueland P.M. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 55(11):1998;1449-1455.
5. Riggs K.M., Spiro A. III, Tucker K., Rush D. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the Normative Aging Study. Am. J. Clin. Nutr. 63(3):1996;306-314.
6. Morris M.S., Jacques P.F., Rosenberg I.H., Selhub J. Hyperhomocysteinemia associated with poor recall in the third national health and nutrition examination survey. Am. J. Clin. Nutr. 73(5):2001;927-933.
7. Mudd S.H., Skovby F., Levy H.L., Pettigrew K.D., Wilcken B., Pyeritz R.E.et al. The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am. J. Hum. Genet. 37(1):1985;1-31.
8. Quinn C.T., Griener J.C., Bottiglieri T., Hyland K., Farrow A., Kamen B.A. Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. J. Clin. Oncol. 15(8):1997;2800-2806.
9. Lubec B., Fang-Kircher S., Lubec T., Blom H.J., Boers G.H. Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim. Biophys. Acta. 1315(3):1996;159-162.
10. Becker A., Scheuch E., Bode U., Jaehde U. Simultaneous analysis of sulfur-containing excitatory amino acids using micellar electrokinetic chromatography with diode array and laser-induced fluorescence detection. Electrophoresis. 23(15):2002;2457-2464.
11. Wuerthele S.E., Yasuda R.P., Freed W.J., Hoffer B.J. The effect of local application of homocysteine on neuronal activity in the central nervous system of the rat. Life Sci. 31(24):1982;2683-2691.
12. Herrling P.L., Maeder J., Meier C.L., Do K.Q. Differential effects of (D)- and (L)-homocysteic acid on the membrane potential of cat caudate neurons in situ. Neuroscience. 31(1):1989;213-217.
13. Lipton S.A., Kim W.K., Choi Y.B., Kumar S., D'Emilia D.M., Rayudu P.V.et al. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. U. S. A. 94(11):1997;5923-5928.
14. Shi Q., Savage J.E., Hufeisen S.J., Rauser L., Grajkowska E., Ernsberger P.et al. L-Homocysteine sulfinic Acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J. Pharmacol. Exp. Ther. 305(1):2003;131-142.
15. Zieminska E., Stafiej A., Lazarewicz J.W. Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neurodegeneration of cultured cerebellar granule neurones. Neurochem. Int. 43(4-5):2003;481-492.
16. Folbergrova J., Haugvicova R., Mares P. Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. Exp. Neurol. 161(1):2000;336-345.
17. Streck E.L., Matte C., Vieira P.S., Rombaldi F., Wannmacher C.M., Wajner M.et al. Reduction of Na(+),K(+)-ATPase activity in hippocampus of rats subjected to chemically induced hyperhomocysteinemia. Neurochem. Res. 27(12):2002;1593-1598.
18. Thompson G.A., Kilpatrick I.C. The neurotransmitter candidature of sulphur-containing excitatory amino acids in the mammalian central nervous system. Pharmacol. Ther. 72(1):1996;25-36.
19. F. Otto, P. Görtz, W. Fleischer, M. Siebler, Cryopreserved rat cortical cells develop functional neuronal networks on microelectrode arrays. J. Neurosci. Methods [in press].
20. Gross G.W., Rhoades B.K., Azzazy H.M., Wu M.C. The use of neuronal networks on multielectrode arrays as biosensors. Biosens. Bioelectron. 10(6-7):1995;553-567.
21. Stichel C.C., Muller H.W. Expression of inherent neuronal shape characteristics after transient sensitivity to epigenetic factors. Brain Res. Dev. Brain Res. 68(2):1992;149-162.
22. Gortz P., Koller H., Schwahn B., Wendel U., Siebler M. Disturbance of cultured rat neuronal network activity depends on concentration and ratio of leucine and alpha-ketoisocaproate: implication for acute encephalopathy of maple syrup urine disease. Pediatr. Res. 53(2):2003;320-324.
23. Fritzer-Szekeres M., Blom H.J., Boers G.H., Szekeres T., Lubec B. Growth promotion by homocysteine but not by homocysteic acid: a role for excessive growth in homocystinuria or proliferation in hyperhomocysteinemia? Biochim. Biophys. Acta. 1407(1):1998;1-6.
24. Nygard O., Refsum H., Ueland P.M., Vollset S.E. Major lifestyle determinants of plasma total homocysteine distribution: The Hordaland Homocysteine Study. Am. J. Clin. Nutr. 67(2):1998;263-270.
25. Franken D.G., Blom H.J., Boers G.H., Tangerman A., Thomas C.M., Trijbels F.J. Thiamine (vitamin B1) supplementation does not reduce fasting blood homocysteine concentration in most homozygotes for homocystinuria. Biochim. Biophys. Acta. 1317(2):1996;101-104.
26. Turski L., Meldrum B.S., Collins J.F. Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist? Brain Res. 336(1):1985;162-166.
27. Folbergrova J. Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats. Exp. Neurol. 145(2 Pt 1):1997;442-450.
28. Ho P.I., Ortiz D., Rogers E., Shea T.B. Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. J. Neurosci. Res. 70(5):2002;694-702.
29. Kim J.P., Koh J.Y., Choi D.W. L-Homocysteate is a potent neurotoxin on cultured cortical neurons. Brain Res. 437(1):1987;103-110.
30. Gorman A., Griffiths R. Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors. Neuroscience. 59(2):1994;299-308.
31. Selhub J., Jacques P.F., Bostom A.G., Wilson P.W., Rosenberg I.H. Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification. Public Health Rev. 28(1-4):2000;117-145.