Leptin but not Ciliary Neurotrophic Factor (CNTF) induces phosphotyrosine phosphatase-1B expression in human neuronal cells (SH-SY5Y): Putative explanation of CNTF efficacy in leptin-resistant state

Endocrinology

Volumn 150, Issue 3, 2009, Pages 1182-1191

  Benomar, Yacir ^a   Berthou, Flavien ^a   Vacher, Claire Marie ^a   Bailleux, Virginie ^a   Gertler, Arieh ^c   Djiane, Jean ^a   Taouis, Mohammed ^a,b,c  

^a INSTITUT D'OPTIQUE GRADUATE SCHOOL   (France)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; INSULIN; JANUS KINASE 2; LEPTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN TYROSINE PHOSPHATASE 1B; STAT3 PROTEIN; PTPN1 PROTEIN, HUMAN;

ARCUATE NUCLEUS; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; DESENSITIZATION; DRUG EFFECT; ENZYME PHOSPHORYLATION; FOOD INTAKE; GENE INDUCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPOTHALAMUS; MOLECULAR INTERACTION; NEUROBLASTOMA CELL; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL LINE; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MOUSE; NERVE CELL; PHOSPHORYLATION; TREATMENT OUTCOME; UPREGULATION;

ANIMALS; CELL LINE; CILIARY NEUROTROPHIC FACTOR; DRUG RESISTANCE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN; LEPTIN; MALE; MICE; MICE, INBRED C57BL; NEURONS; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TREATMENT OUTCOME; UP-REGULATION;

EID: 67649859159     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1097     Document Type: Article

References (43)

1. Ahima RS, Saper CB, Flier JS, Elmquist JK 2000 Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21:263-307
2. Friedman JM, Halaas JL 1998 Leptin and the regulation of body weight in mammals. Nature 395:763-770
3. Elmquist JK, Maratos-Flier E, Saper CB, Flier JS 1998 Unraveling the central nervous system pathways underlying response to leptin. Nat Neurosci 1:445-449
4. Bates SH, Myers Jr MG 2003 The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab 14:447-452
5. Considine RV, Sinha MK, Heiman ML, Krianciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro, JF 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295
6. Zhang Y, Scarpace PJ 2006 The role of leptin in leptin resistance and obesity. Physiol Behav 88:249-256
7. Munzbzerg H, Myers Jr MG 2005 Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 8:566-570
8. Roth J 1998 Diabetes and obesity. Diab Met Rev 13:1-2
9. Bjorbaek C, El Hashimi K, Frantz JD, Flier JS 1999 The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 274:30059-30065
10. Munzberg H, Flier JS, Bjorbaek C 2004 Region-specific leptin resistance within the hypothalamus of diet-induced-obese mice. Endocrinology 145:4880-4889
11. ElHashimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS 2000 Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105:1827-1832
12. Banks WA 2003 Is obesity a disease of the blood-brain barrier? Physiological, pathological and evolutionary considerations. Curr Pharma Design 9:801-809
13. Gloaguen I, Costa P, Demartis A, Lazzaro D, Di Marco A, Graziani R, Paonessa G, Ghen F, Rosenblum CI, Van Der Ploeg LHT, Cortese R, Ciliberto G, Laufer R 1997 Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci USA 94:6456-6461
14. Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ 2001 Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even inleptin-resistant obesity. Proc Natl Acad Sci USA 98:4652-4657
15. Sleeman MW, Garcia K, Liu R, Murray JD, Malinova L, Moncrieffe M, Yancopoulos GD, Wiegand SJ 2003 Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice. Proc Natl Acad Sci USA 100:14297-14302
16. Anderson KD, Lambert PD, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ 2003 Activation of the hypothalamic arcuate nucleus predicts the anorectic actions of ciliary neurotrophic factor and leptin in intactand gold thioglucose-lesioned mice. J Neuroendocrinol 15:649-660
17. Janoscheck R, Plum L, Koch L, Munzberg H, Diano S, Shanabrough M, Muller W, Horvarth TL, Bruning JC 2006 gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Proc Natl Acad Sci USA 103:10707-10712
18. MacLennan AJ, Vinson EN, Marks L, McLaurin DL, Pfeifer M, Lee N 1996 Immunohistochemical localization of ciliary neurotrophic factor receptor α expression in the rat nervous system. J Neurosci 16:621-630
19. Prima V, Tennant M, Gorbatyuk OS, Muzyczka N, Scarpace PJ, Zolotukhin S 2004 Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory fact or gene delivery: microarray deoxyribonucleic acid-Chip analysis of gene expression. Endocrinology 145:2035-2045
20. Kelly JF, Elias CF, Lee CE, Ahima R, Seeley RJ, Bjorbaek C, Oka T, Saper CB, Flier JS, Elmquist JK 2004 Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain. Diabetes 53:911-920
21. Benomar Y, Roy AF, Aubourg A, Djiane J, Taouis M 2005 Cross down-regulation of leptin and insulin receptor expression and signaling in human neuronal cell line. Biochem J 388:929-939
22. Kaur N, Wohlhueter AL, Halvorsen SW 2002 Activation and inactivation of signal transducers and activators of transcription by ciliary neurotrophic factor in neuroblastoma cells. Cell Signal 14:419-429
23. Russo VC, Metaxas S, Kobayashi K, Harris M, Werther GA 2004 Antiapoptotic effects of leptin in human neuroblastoma cells. Endocrinology 145:4103-4112
24. Jang EH, Park CS, Lee SK, Pie JE, Kang JH 2007 Excessive nitric oxide attenuates leptin-mediated signal transducer and activator of transcription 3 activation. Life Sci 80:609-617
25. Greco SJ, Sarkar S, Johnston JM, Zhu X, Su B, Casadesus G, Ashford JW, Smith MA, Tezapsidis N 2008 Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochem Biophys Res Commun 376:536-541
26. Benomar Y, Naour N, Aubourg A, Bailleux V, Gertler A, Djiane J, Guerre-Millo M, Taouis M 2006 Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a PI 3-kinase dependent mechanism. Endocrinology 147:2550-2556
27. Gertler A, Simmons J, Keisler DH 1998 Large-scale preparation of biologically active recombinant ovine obese protein (leptin). FEBS Lett 422:137-140
28. Vacher CM, Fretier P, Creminion C, Calas A, Hardin-Pouzet H 2002 Activation by serotonin and noradrenaline of vasopressin and oxytocin expression in the mouse paraventricular and supraoptic nuclei. J Neurosci 22:1513-1522
29. Jiao J, Kaur N, Lu B, Reeves SA, Halvorsen SW 2003 Initiation and maintenance of CNTF-JAK/STAT signaling in neurons is blocked by protein tyrosin phosphatase inhibitors. Mol Brain Res 116:135-146
30. Steinberg GR, Smith AC, Wormald S, Malenfant P, Collier C, Dyck DJ 2004 Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle. Am J Physiol 286:E57-E63
31. Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ 1997 A family of cytokine-inducible inhibitors of signaling. Nature 387:917-921
32. Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS 1998 Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1:619-625
33. Dunn S, Bkjornholm M, Bates SH, Chen Z, Seifert M, Myers MG 2005 Feedback inhibition of leptin receptor/JAK-2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol 19:925-938
34. Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A 2004 SOCS-3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet induced obesity. Nat Med 10:739-743
35. Zvonic S, Baugh JE, Arbour-Reily P, Mynatt RL, Stephens JM 2005 Cross-talk among gp130 cytokines in adipocytes. J Biol Chem 280:33856-33863
36. Roy AF, Bailleux V, Vacher CM, Aubourg A, Gertler A, Djiane J, Taouis M 2007 Lack of cross-desensitization between leptin and prolactin signaling pathways despite the induction of SOCS-3 and PTP-1B. J Endocrinol 195:341-350
37. Frobose H, Ronn SG, Heding PE, Mendoza H, Cohen P, Mandrup-Poulsen T, Billestrup N 2006 Suppressor of cytokine signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex. Mol Endocrinol 20:1587-1596
38. Lund IK, Hansen JA, Andersen HS, Moler NPH, Billestrup N 2005 Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signaling. J Mol Endocrinol 34:339-351
39. Lam NT, Covey SD, Lewis JT, Oosman S, Webber T, Hsu EC, Cheung AT, Kieffer TJ 2006 Leptin resistance following over-expression of protein tyrosine phosphatase 1B in liver. J Mol Endocrinol 36:163-174
40. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotony JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB 2000 Increased energy expenditure, decreased adiposity and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20:5479-5489
41. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB 2006 Neuronal PTP-1B regulates body weight, adiposity and leptin action. Nat Med 12:917-924
42. Morrison CD, White CL, Wang Z, Lee SY, Lawrence DS, Cefalu WT, Zhang ZY, Gettys TW 2007 Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology 148:433-440
43. Lam NT, Lewis JT, Cheung AT, Luk CT, Tse J, Wang J, Bryer-Ash M, Kolls JK, Kieffer TJ 2004 Leptin increases hepatic insulin sensitivity and protein phosphatase 1B expression. Mol Endocrinol 18:1333-1345