Differential modulation of energy balance by leptin, ciliary neurotrophic factor, and leukemia inhibitory factor gene delivery: Microarray deoxyribonucleic acid-chip analysis of gene expression

Endocrinology

Volumn 145, Issue 4, 2004, Pages 2035-2045

  Prima, V ^a   Tennant, M ^a   Gorbatyuk, O S ^a   Muzyczka, N ^a   Scarpace, P J ^a   Zolotukhin, S ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYTOKINE; INTERLEUKIN 6; LEPTIN; LEUKEMIA INHIBITORY FACTOR;

ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; CACHEXIA; CHRONIC INFLAMMATION; CONTROLLED STUDY; DNA MICROARRAY; ENERGY BALANCE; FOOD INTAKE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE TARGETING; HORMONE RESISTANCE; HYPOTHALAMUS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSGENE; UNINDEXED SEQUENCE; VIRAL GENE DELIVERY SYSTEM; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; CILIARY NEUROTROPHIC FACTOR; DEPENDOVIRUS; DNA; EATING; ENERGY METABOLISM; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; INTERLEUKIN-6; LEPTIN; LEUKEMIA INHIBITORY FACTOR; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 1642570481     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1376     Document Type: Article

References (60)

1. Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM 1997 Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 94:8878-8883
2. Sahu A 2002 Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones. J Neuroendocrinol 14:796-804
3. Wilsey J, Zolotukhin S, Prima V, Scarpace PJ 2003 Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 285:R1011-R1020
4. Scarpace PJ, Matheny M, Zhang Y, Tumer N, Frase CD, Shek EW, Hong B, Prima V, Zolotukhin S 2002 Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats. Neuropharmacology 42:548-561
5. Scarpace PJ, Matheny M, Zolotukhin S, Tumer N, Zhang Y 2003 Leptin-induced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II. Neuropharmacology 45:211-219
6. Scarpace PJ, Matheny M, Zhang Y, Shek EW, Prima V, Zolotukhin S, Tumer N 2002 Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology 143:3026-3035
7. Gloaguen I, Costa P, Demartis A, Lazzaro D, Di Marco A, Graziani R, Paonessa G, Chen F, Rosenblum CI, Van der Ploeg LH, Cortese R, Ciliberto G, Laufer R 1997 Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci USA 94:6456-6461
8. Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ 2001 Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci USA 98:4652-4657
9. Ettinger MP, Littlejohn TW, Schwartz SL, Weiss SR, McIlwain HH, Heymsfield SB, Bray GA, Roberts WG, Heyman ER, Stambler N, Heshka S, Vicary C, Guler HP 2003 Recombinant variant of ciliary neurotrophic factor for weight loss in obese adults: a randomized, dose-ranging study. JAMA 289:1826-1832
10. Turnley AM, Bartlett PF 2000 Cytokines that signal through the leukemia inhibitory factor receptor-β complex in the nervous system. J Neurochem 74:889-899
11. Metcalf D, Gearing DP 1989 Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor. Proc Natl Acad Sci USA 86:5948-5952
12. Ikeda K, Iwasaki Y, Shiojima T, Kinoshita M 1996 Neuroprotective effect of various cytokines on developing spinal motoneurons following axotomy. J Neurol Sci 135:109-113
13. Kurek JB, Radford AJ, Crump DE, Bower JJ, Feeney SJ, Austin L, Byrne E 1998 LIF (AM424), a promising growth factor for the treatment of ALS. J Neurol Sci 160(Suppl 1):S106-S113
14. McKay Hart A, Wiberg M, Terenghi G 2003 Exogenous leukaemia inhibitory factor enhances nerve regeneration after late secondary repair using a bioartificial nerve conduit. Br J Plast Surg 56:444-450
15. Zou Y, Takano H, Mizukami M, Akazawa H, Qin Y, Toko H, Sakamoto M, Minamino T, Nagai T, Komuro I 2003 Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction. Circulation 108:748-753
16. Feeney SJ, Austin L, Bennett TM, Kurek JB, Jean-Francois MJ, Muldoon C, Byrne E 2003 The effect of leukaemia inhibitory factor on SOD1 G93A murine amyotrophic lateral sclerosis. Cytokine 23:108-118
17. Azari MF, Lopes EC, Stubna C, Turner BJ, Zang D, Nicola NA, Kurek JB, Cheema SS 2003 Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1(G93A G1H) mouse model of familial amyotrophic lateral sclerosis. Brain Res 982:92-97
18. Laura M, Gregson NA, Curmi Y, Hughes RA 2002 Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis. J Neuroimmunol 133: 56-59
19. Kurek J 2000 AM424: history of a novel drug candidate. Clin Exp Pharmacol Physiol 27:553-557
20. Beretta E, Dhillon H, Kalra PS, Kalra SP 2002 Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods. Peptides 23:975-984
21. Pan W, Kastin AJ, Brennan JM 2000 Saturable entry of leukemia inhibitory factor from blood to the central nervous system. J Neuroimmunol 106:172-180
22. Bok D, Yasumura D, Matthes MT, Ruiz A, Duncan JL, Chappelow AV, Zolotukhin S, Hauswirth W, LaVail MM 2002 Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res 74:719-735
23. Mori M, Yamaguchi K, Honda S, Nagasaki K, Ueda M, Abe O, Abe K 1991 Cancer cachexia syndrome developed in nude mice bearing melanoma cells producing leukemia-inhibitory factor. Cancer Res 51:6656-6659
24. Zolotukhin S, Byrne BJ, Mason E, Zolotukhin I, Potter M, Chesnut K, Summerford C, Samulski RJ, Muzyczka N 1999 Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther 6:973-985
25. Grimm D, Kern A, Rittner K, Kleinschmidt JA 1998 Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum Gene Ther 9:2745-2760
26. Almeida TA, Perez JA, Pinto FM 2000 Size-fractionation of RNA by hot agarose electrophoresis. Biotechniques 28:414-416
27. Sambrook J, Fritsch EF, Maniatis T 2001 Molecular cloning: a laboratory manual. 3rd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
28. Austin L, Bower JJ, Kurek JB, Muldoon CM 1997 Controlled release of leukaemia inhibitory factor (LIF) to tissues. Growth Factors 15:61-68
29. Meister B, Hakansson ML 2001 Leptin receptors in hypothalamus and circumventricular organs. Clin Exp Pharmacol Physiol 28:610-617
30. Ahima RS, Kelly J, Elmquist JK, Flier JS 1999 Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology 140:4923-4931
31. Ahima RS, Saper CB, Flier JS, Elmquist JK 2000 Leptin regulation of neuroendocrine systems. Front Neuroendocrinol 21:263-307
32. Broberger C, Hokfelt T 2001 Hypothalamic and vagal neuropeptide circuitries regulating food intake. Physiol Behav 74:669-682
33. Elmquist JK 2001 Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Physiol Behav 74:703-708
34. Toni R, Jackson IM, Lechan RM 1990 Neuropeptide-Y-immunoreactive innervation of thyrotropin-releasing hormone-synthesizing neurons in the rat hypothalamic paraventricular nucleus. Endocrinology 126:2444-2453
35. Broberger C, Visser TJ, Kuhar MJ, Hokfelt T 1999 Neuropeptide Y innervation and neuropeptide-Y-Y1-receptor-expressing neurons in the paraventricular hypothalamic nucleus of the mouse. Neuroendocrinology 70:295-305
36. Diano S, Naftolin F, Goglia F, Horvath TL 1998 Segregation of the intra-and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormone. Regul Pept 75-76:117-126
37. Fekete C, Legradi G, Mihaly E, Tatro JB, Rand WM, Lechan RM 2000 α-Melanocyte stimulating hormone prevents fasting-induced suppression of corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus. Neurosci Lett 289:152-156
38. Legradi G, Lechan RM 1998 The arcuate nucleus is the major source for neuropeptide Y-innervation of thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 139:3262-3270
39. Li C, Chen P, Smith MS 2000 Corticotropin releasing hormone neurons in the paraventricular nucleus are direct targets for neuropeptide Y neurons in the arcuate nucleus: an anterograde tracing study. Brain Res 854:122-129
40. Kagotani Y, Tsuruo Y, Hisano S, Daikoku S, Chihara K 1989 Synaptic regulation of paraventricular arginine vasopressin-containing neurons by neuropeptide Y-containing monoaminergic neurons in rats. Electron-microscopic triple labeling. Cell Tissue Res 257:269-278
41. Piekut DT 1985 Relationship of ACTH1-39-immunostained fibers and magnocellular neurons in the paraventricular nucleus of rat hypothalamus. Peptides 6:883-890
42. Sawchenko PE, Pfeif fer SW 1988 Ultrastructural localization of neuropeptide Y and galanin immunoreactivity in the paraventricular nucleus of the hypothalamus in the rat. Brain Res 474:231-245
43. Morimoto I, Yamamoto S, Kai K, Fujihira T, Monta E, Eto S 2000 Centrally administered murine-leptin stimulates the hypothalamus-pituitary-adrenal axis through arginine-vasopressin. Neuroendocrinology 71:366-374
44. Tanimura SM, Watts AG 1998 Corticosterone can facilitate as well as inhibit corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus. Endocrinology 139:3830-3836
45. Billington CJ, Briggs JE, Grace M, Levine AS 1991 Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am J Physiol 260:R321-R327
46. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y 1997 Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 94:10455-10460
47. Marsh DJ, Hollopeter G, Huszar D, Laufer R, Yagaloff KA, Fisher SL, Burn P, Palmiter RD 1999 Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21:119-122
48. Turrin NP, Plata-Salaman CR 2000 Cytokine-cytokine interactions and the brain. Brain Res Bull 51:3-9
49. Wagstaff MJ, Collaco-Moraes Y, Smith J, de Belleroche JS, Coffin RS, Latchman DS 1999 Protection of neuronal cells from apoptosis by Hsp27 delivered with a herpes simplex virus-based vector. J Biol Chem 274:5061-5069
50. David JC, Landry J, Grongnet JF 2000 Perinatal expression of heat-shock protein 27 in brain regions and nonneural tissues of the piglet. J Mol Neurosci 15:109-120
51. Lee JE, Yenari MA, Sun GH, Xu L, Emond MR, Cheng D, Steinberg GK, Giffard RG 2001 Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions. Exp Neurol 170:129-139
52. Harada S, Kamiya K, Masago A, Iwata A, Yamada K 1997 Subarachnoid hemorrhage induces c-fos, c-jun and hsp70 mRNA expression in rat brain. Neuroreport 8:3399-3404
53. Mehlen P, Schulze-Osthoff K, Arrigo AP 1996 Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1-and staurosporine-induced cell death. J Biol Chem 271:16510-16514
54. Akbar MT, Wells DJ, Latchman DS, de Belleroche J 2001 Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration. Brain Res Mol Brain Res 93:148-163
55. Suzuki S, Li AJ, Ishisaki A, Hou X, Hasegawa M, Fukumura M, Akaike T, Imamura T 2001 Feeding suppression by fibroblast growth factor-1 is accompanied by selective induction of heat shock protein 27 in hypothalamic astrocytes. Eur J Neurosci 13:2299-2308
56. Aly KB, Pipkin JL, Hinson WG, Feuers RJ, Duffy PH, Lyn-Cook L, Hart RW 1994 Chronic caloric restriction induces stress proteins in the hypothalamus of rats. Mech Ageing Dev 76:11-23
57. Akiyama Y, Kajimura N, Matsuzaki J, Kikuchi Y, Imai N, Tanigawa M, Yamaguchi K 1997 In vivo effect of recombinant human leukemia inhibitory factor in primates. Jpn J Cancer Res 88:578-583
58. Zolotukhin S, Potter M, Hauswirth WW, Guy J, Muzyczka N 1996 A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells. J Virol 70:4646-4654
59. Miyazaki J, Takaki S, Araki K, Tashiro F, Tominaga A, Takatsu K, Yamamura K 1989 Expression vector system based on the chicken β-actin promoter directs efficient production of interleukin-5. Gene 79: 269-277
60. Loeb JE, Cordier WS, Harris ME, Weitzman MD, Hope TJ 1999 Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy. Hum Gene Ther 10:2295-2305