Ciliary Neurotrophic Factor and Leptin Induce Distinct Patterns of Immediate Early Gene Expression in the Brain

Diabetes

Volumn 53, Issue 4, 2004, Pages 911-920

  Kelly, Joseph F ^a   Elias, Carol F ^b   Lee, Charlotte E ^a   Ahima, Rexford S ^c   Seeley, Randy J ^d   Bjørbæk, Christian ^a   Oka, Takakazu ^a   Saper, Clifford B ^a   Flier, Jeffrey S ^a   Elmquist, Joel K ^a,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^e BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CYCLOOXYGENASE 2; CYTOKINE; CYTOKINE RECEPTOR; CYTOKINE RECEPTOR 1; LEPTIN; LIPOPOLYSACCHARIDE; PYROGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; BRAIN; BRAIN VENTRICLE; CACHEXIA; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPENDYMA CELL; FEVER; FOOD INTAKE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; HYPOTHALAMUS; IMMEDIATE EARLY GENE; INFLAMMATION; MALE; MENINX; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SOCS 3 GENE; TIS 11 GENE;

ANIMALS; BRAIN; CILIARY NEUROTROPHIC FACTOR; CYCLOOXYGENASE 2; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, IMMEDIATE-EARLY; HUMANS; IMMEDIATE-EARLY PROTEINS; ISOENZYMES; KINETICS; LEPTIN; LIPOPOLYSACCHARIDES; LITHIUM CHLORIDE; MALE; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; RNA, MESSENGER; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRISTETRAPROLIN; ZINC FINGERS;

EID: 12144287927     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.4.911     Document Type: Article

References (53)

1. Friedman JM, Halaas JL: Leptin and the regulation of body weight in mammals. Nature 395:763-770, 1998
2. Tartaglia LA: The leptin receptor. J Biol Chem 272:6093-6096, 1997
3. Woods SC, Seeley RJ, Porte D Jr, Schwartz MW: Signals that regulate food intake and energy homeostasis. Science 280:1378-1383, 1998
4. Elmquist JK, Elias CF, Saper CB: From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22:221-232, 1999
5. Gloaguen I, Costa P, Demartis A, Lazzaro D, Di Marco A, Graziani R, Paonessa G, Chen F, Rosenblum CI, Van der Ploeg LHT, Cortese R, Ciliberto G, Laufer R: Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci U S A 94:6456-6461, 1997
6. Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ: Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci U S A 98:4652-4657, 2001
7. Sleeman MW, Garcia K, Liu R, Murray JD, Malinova L, Moncrieffe M, Yancopoulos GD, Wiegand SJ: Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice. Proc Natl Acad Sci U S A 100: 14297-14302, 2003
8. Kordower JH, Yaping C, Maclennan AJ: Ciliary neurotrophic factor receptor alpha-immunoreactivity in the monkey central nervous system. J Comp Neurol 377:365-380, 1997
9. Segal RA, Greenberg ME: Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 19:463-489, 1996
10. Elmquist JK, Maratos-Flier E, Saper CB, Flier JS: Unraveling the central nervous system pathways underlying responses to leptin. Nat Neurosci 1:445-450, 1998
11. Anderson KD, Lambert PD, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ: Activation of the hypothalamic arcuate nucleus predicts the anorectic actions of ciliary neurotrophic factor and leptin in intact and gold thioglucose-lesioned mice. J Neuroendocrinol 15:649-660, 2003
12. Elmquist JK, Scammell TE, Saper CB: Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends Neurosci 20: 565-570, 1997
13. Rivest S, Lacroix S, Vallieres L, Nadeau S, Zhang J, Laflamme N: How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc Soc Exp Biol Med 223:22-38, 2000
14. Elias CF, Kelly JF, Lee CE, Ahima RS, Drucker DJ, Saper CB, Elmquist JK: Chemical characterization of leptin-activated neurons in the rat brain. J Comp Neurol 423:261-281, 2000
15. Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK: Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21:1375-1385, 1998
16. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK: Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23:775-786, 1999
17. Kaneda N, Oshima M, Chung SY, Guroff G: Sequence of a rat TIS11 cDNA, an immediate early gene induced by growth factors and phorbol esters. Gene 118:289-291, 1992
18. Treisman R: Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences. Cell 42:889-902, 1985
19. Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS: Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1:619-625, 1998
20. Feng L, Sun W, Xia Y, Tang WW, Chanmugam P, Soyoola E, Wilson CB, Hwang D: Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Arch Biochem Biophys 307:361-368, 1993
21. Breder CD, Dewitt D, Kraig RP: Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol 355:296-315, 1995
22. Hakansson ML, Hulting AL, Meister B: Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus: relationship with NPY neurones. Neuroreport 7:3087-3092, 1996
23. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P: Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 387:113-116, 1996
24. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG: Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98:1101-1106, 1996
25. Van Dijk G, Thiele TE, Donahey JC, Campfield LA, Smith FJ, Burn P, Bernstein IL, Woods SC, Seeley RJ: Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am J Physiol 271:R1096-R1100, 1996
26. Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS, Saper CB: Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138:839-842, 1997
27. Lebel E, Vallieres L, Rivest S: Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges. Endocrinology 141:3749-3763, 2000
28. Shapiro L, Zhang XX, Rupp RG, Wolff SM, Dinarello CA: Ciliary neurotrophic factor is an endogenous pyrogen. Proc Natl Acad Sci U S A 90:8614-8618, 1993
29. Espat NJ, Auffenberg T, Rosenberg JJ, Rogy M, Martin D, Fang CH, Hasselgren PO, Copeland EM, Moldawer LL: Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response. Am J Physiol 271:R185-R190, 1996
30. Miller RG, Bryan WW, Dietz MA, Munsat TL, Petajan JH, Smith SA, Goodpasture JC: Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis. Neurology 47:1329-1331, 1996
31. Miller RG, Petajan JH, Bryan WW, Armon C, Barohn RJ, Goodpasture JC, Hoagland RJ, Parry GJ, Ross MA, Stromatt SC: A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis: rhCNTF ALS Study Group. Ann Neurol 39:256-260, 1996
32. Ip NY, Yancopoulos GD: The neurotrophins and CNTF: two families of collaborative neurotrophic factors. Annu Rev Neurosci 19:491-515, 1996
33. Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A: A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387:921-924, 1997
34. Naka T, Narazaki M, Hirata M, Matsumoto T, Minamoto S, Aono A, Nishimoto N, Kajita T, Taga T, Yoshizaki K, Akira S, Kishimoto T: Structure and function of a new STAT-induced STAT inhibitor. Nature 387:924-929, 1997
35. Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ: A family of cytokine-inducible inhibitors of signalling. Nature 387:917-921, 1997
36. Bjorbaek C, Elmquist JK, El-Haschimi K, Kelly J, Ahima RS, Hileman S, Flier JS: Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Endocrinology 140:2035-2043, 1999
37. Varnum BC, Lim RW, Kujubu DA, Luner SJ, Kaufman SE, Greenberger JS, Gasson JC, Herschman HR: Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of primary-response TIS genes in both proliferating and terminally differentiated myeloid cells. Mol Cell Biol 9:3580-3583, 1989
38. Chan RK, Brown ER, Ericsson A, Kovacs KJ, Sawchenko PE: A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. J Neurosci 13:5126-5138, 1993
39. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, Low MJ: Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-484, 2001
40. Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB: Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci U S A 95:741-746, 1998
41. MacLennan AJ, Vinson EN, Marks L, McLaurin DL, Pfeifer M, Lee N: Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system. J Neurosci 16:621-630, 1996
42. Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB: Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395:535-547, 1998
43. Elmquist JK, Scammell TE, Jacobson CD, Saper CB: Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration. J Comp Neurol 371:85-103, 1996
44. Rivest S, Laflamme N: Neuronal activity and neuropeptide gene transcription in the brahis of immune-challenged rats. J Neuroendocrinol 7:501-525, 1995
45. Reyes TM, Sawchenko PE: Involvement of the arcuate nucleus of the hypothalamus in interleukin-l-induced anorexia. J Neurosci 22:5091-5099, 2002
46. Marks DL, Cone RD: Central melanocortins and the regulation of weight during acute and chronic disease. Recent Prog Horm Res 56:359-375, 2001
47. Marks DL, Ling N, Cone RD: Role of the central melanocortin system in cachexia. Cancer Res 61:1432-1438, 2001
48. Wisse BE, Frayo RS, Schwartz MW, Cummings DE: Reversal of cancer anorexia by blockade of central melanocortin receptors in rats. Endocrinology 142:3292-3301, 2001
49. Lechan RM, Tatro JB: Hypothalamic melanocortin signaling in cachexia. Endocrinology 142:3288-3291, 2001
50. Huang QH, Hruby VJ, Tatro JB: Role of central melanocortins in endotoxin-induced anorexia. Am J Physiol 276:R864-R871, 1999
51. Bergen HT, Mizuno TM, Taylor J, Mobbs CV: Hyperphagia and weight gain after gold-thioglucose: relation to hypothalamic neuropeptide Y and proopiomelanocortin. Endocrinology 139:4483-4488, 1998
52. Ziotopoulou M, Erani DM, Hileman SM, Bjorbaek C, Mantzoros CS: Unlike leptin, ciliary neurotrophic factor does not reverse the starvation-induced changes of serum corticosterone and hypothalamic neuropeptide levels but induces expression of hypothalamic inhibitors of leptin signaling. Diabetes 49:1890-1896, 2000
53. Luheshi GN, Gardner JD, Rushforth DA, Loudon AS, Rothwell NJ: Leptin actions on food intake and body temperature are mediated by IL-1. Proc Natl Acad Sci U S A 96:7047-7052, 1999