Humanization of an Anti-Lymphocyte Function-Associated Antigen (LFA)-1 Monoclonal Antibody and Reengineering of the Humanized Antibody for Binding to Rhesus LFA-1

Journal of Immunology

Volumn 157, Issue 11, 1996, Pages 4986-4995

  Werther, Winifred A ^a   Gonzalez, Tania N ^a   O'Connor, Shane J ^a   McCabe, Susan ^a   Chan, Betty ^a   Hotaling, Timothy ^a   Champe, Mark ^a   Fox, Judith A ^a   Jardieu, Paula M ^a   Berman, Phillip W ^a   Presta, Leonard G ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY; PRIMER DNA; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BINDING SITE; CELL ADHESION; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; IN VITRO STUDY; KERATINOCYTE; MACACA; METABOLISM; MIXED LYMPHOCYTE CULTURE; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PAN TROGLODYTES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BASE SEQUENCE; BINDING SITES; CELL ADHESION; CLONING, MOLECULAR; DNA PRIMERS; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; INTERCELLULAR ADHESION MOLECULE-1; KERATINOCYTES; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACACA MULATTA; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PAN TROGLODYTES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY;

EID: 0030443253     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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