In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin

Journal of Biological Chemistry

Volumn 280, Issue 1, 2005, Pages 607-617

  Ho, Mitchell ^a   Kreitman, Robert J ^a   Onda, Masanori ^a   Pastan, Ira ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELLS; DISEASES; DNA; DRUG THERAPY; MUTAGENESIS; PATIENT TREATMENT;

COMPLEMENTARITY-DETERMINING REGION (CDR); IMMUNOTOXIN; LEUKEMIA; SOMATIC MUTATION;

IMMUNOLOGY;

ASPARAGINE; CD22 ANTIGEN; IMMUNOTOXIN; SERINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; ARTICLE; B CELL LYMPHOMA; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CYTOTOXICITY; GENE ACTIVITY; GENE CONSTRUCT; GENE LIBRARY; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGHT CHAIN; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN TARGETING; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGENS, CD; ANTIGENS, CD22; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; BINDING SITES, ANTIBODY; CELL ADHESION MOLECULES; CELL LINE; COMPLEMENTARITY DETERMINING REGIONS; ENTEROTOXINS; GERM-LINE MUTATION; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTOXINS; LECTINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION;

EID: 12844267487     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409783200     Document Type: Article

References (44)

1. Frankel, A. E., Kreitman, R. J., and Sausville, E. A. (2000) Clin. Cancer Res. 6, 326-334
2. Ghetie, V., and Vitetta, E. S. (2001) Mol. Biotechnol. 18, 251-268
3. Pastan, I. (2003) Cancer Immunol. Immunother. 52, 338-341
4. Kreitman, R. J., and Pastan, I. (1995) Semin. Cancer Biol. 6, 297-306
5. Tedder, T. F., Tuscano, J., Sato, S., and Kehrl, J. H. (1997) Annu. Rev. Immunol. 5, 481-504
6. Campana, D., Janossy, G., Bofill, M., Trejdosiewicz, L. K., Ma, D., Hoffbrand, A. V., Mason, D. Y., Lebacq, A. M., and Forster, H. K. (1985) J. Immunol. 134, 1524-1530
7. Brinkmann, U., Reiter, Y., Jung, S. H., Lee, B., and Pastan, I. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 7538-7542
8. Mansfield, E., Amlot, P., Pastan, I., and FitzGerald, D. J. (1997) Blood 90, 2020-2026
9. Kreitman, R. J., Wang, Q. C., FitzGerald, D. J., and Pastan, I. (1999) Int. J. Cancer 81, 148-155
10. Kreitman, R. J., Margulies, I., Stetler-Stevenson, M., Wang, Q. C., FitzGerald, D. J., and Pastan, I. (2000) Clin. Cancer Res. 6, 1476-1487
11. Kreitman, R. J., Wilson, W. H., Bergeron, K., Raggio, M., Stetler-Stevenson, M., FitzGerald, D. J., and Pastan, I. (2001) N. Engl. J. Med. 345, 241-247
12. Rossmann, E. D., Lundin, J., Lenkei, R., Mellstedt, H., and Osterborg, A. (2001) Hematol. J. 2, 300-306
13. Gram, H., Marconi, L. A., Barbas, C. F., III, Collet, T. A., Lerner, R. A., and Kang, A. S. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3576-3580
14. Griffiths, A. D., Malmqvist, M., Marks, J. D., Bye, J. M., Embleton, M. J., McCafferty, J., Baier, M., Holliger, K. P., Gorick, B. D., Hughes-Jones, N. C., Hoogenboom, H. R., and Winter, G. (1993) EMBO J. 12, 725-734
15. de Kruif, J., Boel, E., and Logtenberg, T. (1995) J. Mol. Biol. 248, 97-105
16. Low, N. M., Holliger, P. H., and Winter, G. (1996) J. Mol. Biol. 260, 359-368
17. Hanes, J., Schaffitzel, C., Knappik, A., and Pluckthun, A. (2000) Nat. Biotechnol. 18, 1287-1292
18. Boder, E. T., Midelfort, K. S., and Wittrup, K. D. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 10701-10705
19. Graff, C. P., Chester, K., Begent, R., and Wittrup, K. D. (2004) Protein Eng. Des. Sel. 17, 293-304
20. Cumbers, S. J., Williams, G. T., Davies, S. L., Grenfell, R. L., Takeda, S., Batista, F. D., Sale, J. E., and Neuberger, M. S. (2002) Nat. Biotechnol. 20, 1129-1134
21. Chowdhury, P. S., and Pastan, I. (1999) Nat. Biotechnol. 17, 568-572
22. Neuberger, M. S., and Milstein, C. (1995) Curr. Opin. Immunol. 7, 248-254
23. Jolly, C. J., Wagner, S. D., Rada, C., Klix, N., Milstein, C., and Neuberger, M. S. (1996) Semin. Immunol. 8, 159-168
24. Neuberger, M. S., Ehrenstein, M. R., Klix, N., Jolly, C. J., Yelamos, J., Rada, C., and Milstein, C. (1998) Immunol. Rev. 162, 107-116
25. Neuberger, M. S. (2002) Biochem. Soc. Trans. 30, 341-350
26. Beers, R., Chowdhury, P., Bigner, D., and Pastan, I. (2000) Clin. Cancer Res. 6, 2835-2843
27. Salvatore, G., Beers, R., Margulies, I., Kreitman, R. J., and Pastan, I. (2002) Clin. Cancer Res. 8, 995-1002
28. Hawkins, R. E., Russell, S. J., Baier, M., and Winter, G. (1993) J. Mol. Biol. 234, 958-964
29. Mohammad, R. M., Mohamed, A. N., Hamdan, M. Y., Vo, T., Chen, B., Katato, K, Abubakr, Y. A., Dugan, M. C., and al-Katib, A. (1996) Leukemia (Baltimore) 10, 130-137
30. Benedict, C. A., MacKrell, A. J., and Anderson, W. F. (1997) J. Immunol. Methods 201, 223-231
31. Krauss, J., Arndt, M. A., Martin, A. C., Liu, H., and Rybak, S. M. (2003) Protein Eng. 16, 753-759
32. Scatchard, G. (1949) Ann. N. Y. Acad. Sci. 51, 660-672
33. Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, K. S., and Foeller, C. (1991) Sequences of Proteins of Immunological Interest, 5th Ed., National Institutes of Health Publication 91-3242, Bethesda, MD
34. Lefranc, M. P. (2001) Nucleic Acids Res. 29, 207-209
35. Whitelegg, N. R., and Rees, A. R. (2000) Protein Eng. 13, 819-824
36. Rada, C., Ehrenstein, M. R., Neuberger, M. S., and Milstein, C. (1998) Immunity 9, 135-141
37. Shen, G. L., Li, J. L., Ghetie, M. A., Ghetie, V., May, R. D., Till, M., Brown, A. N., Relf, M., Knowles, P., Uhr, J. W., Janossy, G., Amlot, P., Vitetta, E. S., and Thorpe, P. E. (1988) Int. J. Cancer 42, 792-797
38. Batista, F. D., and Neuberger, M. S. (1998) Immunity 6, 751-759
39. Foote, J., and Eisen, H. N. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1254-1256
40. Wilson, I. A., and Stanfield, R. L. (1994) Curr. Opin. Struct. Biol. 4, 857-867
41. Wang, C. L., Harper, R. A., and Wabl, M. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 7352-7356
42. Newman, M. A., Mainhart, C. R., Mallet, C. P., Lavoie, T. B., and Smith-Gill, S. J. (1992) J. Immunol. 149, 3260-3272
43. Lavoie, T. B., Mohan, S., Lipschultz, C. A., Grivel, J. C., Li, Y., Mainhart, C. R., Kam-Morgan, L. N., Drohan, W. N., and Smith-Gill, S. J. (1999) Mol. Immunol. 36, 1189-1205
44. Li, Y., Li, H., Yang, F., Smith-Gill, S. J., and Mariuzza, R. A. (2003) Nat. Struct. Biol. 10, 482-488