Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

Cell

Volumn 47, Issue 1, 1986, Pages 19-28

  Cleary, Michael L ^a   Smith, Stephen D ^a   Sklar, Jeffrey ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; BLOOD AND HEMOPOIETIC SYSTEM; CELL CULTURE; CHROMOSOME TRANSLOCATION 14; CHROMOSOME TRANSLOCATION 18; EPSTEIN BARR VIRUS; GENETIC ENGINEERING; HEREDITY; HISTOLOGY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IN VITRO STUDY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; COMPARATIVE STUDY; DNA; GENES, STRUCTURAL; HERPESVIRUS 4, HUMAN; HUMAN; IMMUNOGLOBULINS, HEAVY-CHAIN; LEUKEMIA, LYMPHOCYTIC; POLY A; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSLOCATION (GENETICS); VIRAL PROTEINS;

EID: 0022971142     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(86)90362-4     Document Type: Article

References (70)

1. Shotgun DNA sequencing using cloned DNAse l-generated fragments
2. Purification of biologically active globin mRNA by chromatography on oligo(dT)-cellulose
3. DNA sequence and expression of the B95-8 Epstein-Barr virus genome
4. H on chromosome 14 and near a transcriptional unit on 18
5. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
6. Screening λgt recombinant clones by hybridization to single plaques in situ
7. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators
8. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
9. Empirical predictions of protein conformation
10. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint cluster region near a transcriptionally active locus on chromosome 18
11. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma
12. Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma
13. Detection of a second t(14;18) breakpoint cluster region in follicular lymphomas
14. Altered transcription of the c-abl oncogene in K562 and other chronic myelogenous leukemia cells
15. Gene for α-chain of human T-cell receptor: locations on chromosome 14 region involved in T-cell neoplasms
16. Human c-myc oncogene is located on the region of chromosome 8 that is translocated in Burkitt's lymphoma cells
17. The virus genome and its expression in latent infection
18. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia
19. Transcriptional control in the production of liver-specific mRNAs
20. γ4 gene
21. Translocation of an immunoglobulin κ locus to a region 3′ of an unrearranged c-myc on-cogene enhances c-myc transcription
22. Biology of the human malignant lymphomas. IV. Functional characterization of ten histiocytic lymphoma cell lines
23. Proliferation and differentiation of lymphoid cells studies with human lymphoid cell lines and immunoglobulin synthesis
24. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
25. Recognition of protein coding regions in DNA sequences
26. Chromosome abnormalities in poorly differentiated lymphocytic lymphoma
27. An 8-kilobase abl RNA transcript in chronic myelogenous leukemia
28. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene
29. The codon preference plot graphic analysis of protein coding sequences and prediction of gene expression
30. Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements
31. A simple and very efficient method for generating cDNA libraries
32. Histiocytic lymphoma cell lines: immunologic and cytogenetic studies
33. Structural organization of the bcr gene and its role in Ph'translocation
34. Constructing and screening cDNA libraries in λgt10 and λgt11
35. Organization of the Epstein-Barr virus DNA molecule. III. Location of the P3HR-1 deletion junction and characterization of the Notl repeat units that form part of the template for an abundant 12-O-tetra-decanoyl-phorbol-13-acetate induced mRNA transcript
36. Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus
37. Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products
38. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity
39. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes
40. A simple method for displaying the hydropathic character of a protein
41. Translocations among antibody genes in human cancer
42. Rapid and sensitive protein similarity searches
43. A new method for sequencing DNA
44. Removal of a 67-base-pair sequence in the noncoding region of proto-oncogene fos converts it to a transforming gene
45. Restricted number of chromosomal regions implicated in aetiology of human cancer and leukemia
46. Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis
47. Amount of viral DNA in the genome of cells transformed by adenovirus type 2
48. 3′ Non-coding region sequences in eukaryotic messenger RNA
49. Structure of the human immunoglobulin μ locus: characterization of embryonic and rearranged J and D genes
50. Gene segments encoding transmembrane carboxyl termini of immunoglobulin γ chains
51. A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining
52. DNA sequencing with chain-terminating inhibitors
53. Location of the c-yes gene on the human chromosome and its expression in various tissues
54. Fused transcript of abl and bcr genes in chronic myelogenous leukemia
55. Colony formation in vitro by leukemic cells in acute lymphoblastic leukemia (ALL)
56. Cytogenetic and immunophenotypic analysis of cell lines established from patients with T cell leukemia/lymphoma
57. Detection of specific sequences among DNA fragments separated by gel electrophoresis
58. Establishment and characterization of a human histiocytic lymphoma cell line (U-937)
59. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt's lymphoma and murine plasmacytoma cells
60. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
61. Involvement of the bcl-2 gene in human follicular lymphoma
62. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
63. Generation of long mRNA for membrane immunoglobulin γ2a chains by differential splicing
64. The molecular genetics of cellular oncogenes
65. H promoters separated by a large distance
66. Localization of the human cellular oncogene c-yes-1 to chromosome 18 band q21
67. The chromosomal basis of human neoplasia
68. Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphomas