bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

Cell

Volumn 57, Issue 1, 1989, Pages 79-88

  McDonnell, Timothy J ^a   Deane, Natasha ^a   Platt, Frances M ^b   Nunez, Gabriel ^a   Jaeger, Ulrich ^a   McKearn, John P ^b   Korsmeyer, Stanley J ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; B LYMPHOCYTE; CHROMOSOME TRANSLOCATION; FOLLICULAR LYMPHOMA; GENETIC ENGINEERING; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMAL; B-LYMPHOCYTES; CELL DIVISION; CELL SURVIVAL; CHROMOSOME MAPPING; FEMALE; GENE EXPRESSION REGULATION; HYPERGAMMAGLOBULINEMIA; HYPERPLASIA; IMMUNOGLOBULIN G; IMMUNOTOXINS; LYMPHOID TISSUE; LYMPHOMA; MALE; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SPLEEN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0024521441     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(89)90174-8     Document Type: Article

References (46)

1. Cellular myc gene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas
2. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
3. H on chromosome 14 and near a transcriptional unit on 18
4. Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners
5. A shared alloantigenic determinant on la antigens encoded by the I-A and I-E subregions: evidence for I region duplication
6. A monoclonal antibody discriminating between subsets of T and B cells
7. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
8. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint cluster region near a transcriptionally active locus on chromosome 18
9. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
10. Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas
11. Human c-myc oncogene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells
12. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule
13. A technique for radiolabeling DNA restriction fragments to high specific activity
14. Chromosome abnormalities in poorly differentiated lymphocytic lymphoma
15. Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B cell neoplasm with a rearranged BCL2 gene
16. Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells
17. Expression of the bcl-2 gene in mouse B lymphocyte cell lines is differentiation stage specific
18. The Eμ-myc transgenic mouse
19. Fading of immunofluorescence during microscopy: a study of the phenomenon and its remedy
20. Antigens displayed on murine B lymphocyte precursors
21. Immunoglobulin and T-cell receptor genes reveal the clonality, lineage and translocations of lymphoid neoplasms
22. The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice
23. Xenogenic monoclonal antibodies to mouse lymphoid differentiation antigens
24. Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development
25. Monoclonal antibodies specific for murine IgM I
26. There are differences in cytogenetic abnormalities among histologic subtypes of the non-Hodgkin's lymphomas
27. RNA processing errors in patients with β-thalassemia
28. Pathogenesis of Burkitt lymphoma: expression of an activated c-myc oncogene causes the tumorigenic conversion of EBV-infected human B lymphoblasts
29. Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B cell neoplasia
30. Mapping cell surface antigens on mouse pre B cell lines
31. Cell surface antigens expressed by subsets of pre-B cells and B cells
32. Experimental models of lymphoproliferative disease: the mouse as a model for human non-Hodgkin's lymphomas and related leukemias
33. Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation
34. Oncogenic potential of bcl-2 demonstrated by gene transfer
35. Intermediate to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes
36. Alternative promoters and exons, somatic mutation and transcriptional deregulation of the Bcl-2-Ig fusion gene in lymphoma
37. Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas
38. Monoclonal antibodies specific for rat IgG1, IgG2a, and IgG2b subclasses, and kappa chain monotypic and allotypic determinants: reagents for use with rat monoclonal antibodies
39. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells
40. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
41. DNA rearrangements in human follicular lymphoma can involve the 5′ or the 3′ region of the bcl-2 gene
42. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
43. Use of monoclonal anti-mouse immunoglobulin to detect mouse antibodies
44. Multiple recurrent genomic defects in follicular lymphoma