메뉴 건너뛰기




Volumn 87, Issue 4, 2009, Pages 315-323

Clinical application of NKT cell biology in type i (autoimmune) diabetes mellitus

Author keywords

Autoimmunity; Immunoregulation; Mouse models; Tolerance

Indexed keywords

CD1D ANTIGEN;

EID: 67349255227     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2009.5     Document Type: Review
Times cited : (20)

References (119)
  • 1
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti K, Zimmet P. Definition, diagnosis and classification of diabetes mellitus and its complications part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diab Med 1998; 15: 539-553.
    • (1998) Diab Med , vol.15 , pp. 539-553
    • Alberti, K.1    Zimmet, P.2
  • 2
    • 0029589786 scopus 로고
    • The genetics of the NOD mouse
    • Baxter A, Cooke A. The genetics of the NOD mouse. Diab Met Rev 1995; 11: 315-335.
    • (1995) Diab Met Rev , vol.11 , pp. 315-335
    • Baxter, A.1    Cooke, A.2
  • 3
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: A model of immune dysregulation
    • Anderson M, Bluestone J. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 2005; 23:447-485.
    • (2005) Annu Rev Immunol , vol.23 , pp. 447-485
    • Anderson, M.1    Bluestone, J.2
  • 4
    • 0041806713 scopus 로고    scopus 로고
    • A pancreatic {beta}-cell-specific homolog of glucose-6- phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes
    • Hutton J, Eisenbarth G. A pancreatic {beta}-cell-specific homolog of glucose-6- phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes. Proc Natl Acad Sci USA 2003; 100: 8626-8628.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8626-8628
    • Hutton, J.1    Eisenbarth, G.2
  • 5
    • 0032823399 scopus 로고    scopus 로고
    • Identification of an MHC class I-restricted autoantigen in type diabetes by screening an organ-specific cDNA library
    • Wong F, Karttunen J, Dumont C, Wen L, Visintin I, Pilip I et al. Identification of an MHC class I-restricted autoantigen in type diabetes by screening an organ-specific cDNA library. Nat Med1999; 5: 1026-1031.
    • Nat Med1999 , vol.5 , pp. 1026-1031
    • Wong, F.1    Karttunen, J.2    Dumont, C.3    Wen, L.4    Visintin, I.5    Pilip, I.6
  • 6
    • 0029818740 scopus 로고    scopus 로고
    • Autoimmunity to the GM2-islet ganglioside before and at the onset of type I diabetes
    • Dotta F, Gianani R, Previti M, Lenti L, Dionisi S, D'Erme M et al. Autoimmunity to the GM2-islet ganglioside before and at the onset of type I diabetes. Diabetes 1996; 45: 1193-1196.
    • (1996) Diabetes , vol.45 , pp. 1193-1196
    • Dotta, F.1    Gianani, R.2    Previti, M.3    Lenti, L.4    Dionisi, S.5    D'Erme, M.6
  • 7
    • 0028145676 scopus 로고
    • Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice
    • Wegmann D, Norbury-Glaser M, Daniel D. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur J Immunol 1994; 24: 1853-1857.
    • (1994) Eur J Immunol , vol.24 , pp. 1853-1857
    • Wegmann, D.1    Norbury-Glaser, M.2    Daniel, D.3
  • 9
    • 0022646067 scopus 로고
    • TheNOD mouse: Recessive diabetogenic gene in the major histocompatibility complex
    • Hattori M, Buss J, Jackson R, Glimcher L, Dorf M, Minami M et al. TheNOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science 1986; 231: 733-735.
    • (1986) Science , vol.231 , pp. 733-735
    • Hattori, M.1    Buss, J.2    Jackson, R.3    Glimcher, L.4    Dorf, M.5    Minami, M.6
  • 10
    • 0023252262 scopus 로고
    • HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
    • Todd J, Bell J, McDevitt H. HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 1987; 329: 599-604.
    • (1987) Nature , vol.329 , pp. 599-604
    • Todd, J.1    Bell, J.2    McDevitt, H.3
  • 11
    • 0003403213 scopus 로고
    • The first external domain of the non-obese diabetic mouse class II I-Ab chain is unique
    • Acha-Orbea H, McDevitt H. The first external domain of the non-obese diabetic mouse class II I-Ab chain is unique. Proc Natl Acad Sci USA 1987; 84: 2435-2439.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2435-2439
    • Acha-Orbea, H.1    McDevitt, H.2
  • 12
    • 18244400088 scopus 로고    scopus 로고
    • Single cell analysis shows decreasing FoxPand TGFbetacoexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes
    • Pop S, Wong C, Culton D, Clarke S, Tisch R. Single cell analysis shows decreasing FoxPand TGFbetacoexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med 2005; 201: 1333-1346.
    • (2005) J Exp Med , vol.201 , pp. 1333-1346
    • Pop, S.1    Wong, C.2    Culton, D.3    Clarke, S.4    Tisch, R.5
  • 13
    • 0030615214 scopus 로고    scopus 로고
    • Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice
    • Baxter AG, Kinder SJ, Hammond KJ, Scollay R, Godfrey DI. Association between alphabetaTCR+CD4-CD8- T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 1997; 46:572-582.
    • (1997) Diabetes , vol.46 , pp. 572-582
    • Baxter, A.G.1    Kinder, S.J.2    Hammond, K.J.3    Scollay, R.4    Godfrey, D.I.5
  • 14
    • 0031171897 scopus 로고    scopus 로고
    • Flow cytometric study of T cell development in NOD mice reveals a deficiency in alphabetaTCR+CDR-CD8- thymo- cytes
    • Godfrey DI, Kinder SJ, Silvera P, Baxter AG. Flow cytometric study of T cell development in NOD mice reveals a deficiency in alphabetaTCR+CDR-CD8- thymo- cytes. J Autoimmun 1997; 10: 279-285.
    • (1997) J Autoimmun , vol.10 , pp. 279-285
    • Godfrey, D.I.1    Kinder, S.J.2    Silvera, P.3    Baxter, A.G.4
  • 16
    • 10044286529 scopus 로고    scopus 로고
    • Going both ways: Immune regulation via CD1d-dependent NKT cells
    • Godfrey DI, Kronenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J ClinInvest 2004; 114: 1379-1388.
    • (2004) J ClinInvest , vol.114 , pp. 1379-1388
    • Godfrey, D.I.1    Kronenberg, M.2
  • 17
    • 0028169443 scopus 로고
    • An invariant Va24-JaQ/VbT cell receptor is expressed in all individuals by clonally expanded CDT cells
    • Dellabona P, Padovan E, Casorati M, Brockhaus M, Lanzavecchia A. An invariant Va24-JaQ/VbT cell receptor is expressed in all individuals by clonally expanded CDT cells. J Exp Med 1994; 180: 1171-1176.
    • (1994) J Exp Med , vol.180 , pp. 1171-1176
    • Dellabona, P.1    Padovan, E.2    Casorati, M.3    Brockhaus, M.4    Lanzavecchia, A.5
  • 18
    • 0028025074 scopus 로고
    • An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in miceand humans
    • Lantz O, Bendelac A. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in miceand humans. J Exp Med 1994; 180: 1097-1106.
    • (1994) J Exp Med , vol.180 , pp. 1097-1106
    • Lantz, O.1    Bendelac, A.2
  • 19
    • 0027178514 scopus 로고
    • Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several Vbeta genes and an invariant TCR alpha chain
    • Porcelli S, Yockey C, Brenner M, Balk S. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several Vbeta genes and an invariant TCR alpha chain. J Exp Med 1993; 178:1-16.
    • (1993) J Exp Med , vol.178 , pp. 1-16
    • Porcelli, S.1    Yockey, C.2    Brenner, M.3    Balk, S.4
  • 20
    • 0036676974 scopus 로고    scopus 로고
    • The unconventional lifestyle of NKT cells
    • Kronenberg M, Gapin L. The unconventional lifestyle of NKT cells. Nat Rev Immunol 2002; 2:557-568.
    • (2002) Nat Rev Immunol , vol.2 , pp. 557-568
    • Kronenberg, M.1    Gapin, L.2
  • 22
    • 34249059942 scopus 로고    scopus 로고
    • Identification of an IL-17-producingNK1.1(neg)iNKTcell population involvedin airwayneutrophilia
    • Michel ML, Keller AC, Paget C, Fujio M, Trottein F, Savage PB et al. Identification of an IL-17-producingNK1.1(neg)iNKTcell population involvedin airwayneutrophilia. J Exp Med 2007; 204: 995-1001.
    • (2007) J Exp Med , vol.204 , pp. 995-1001
    • Michel, M.L.1    Keller, A.C.2    Paget, C.3    Fujio, M.4    Trottein, F.5    Savage, P.B.6
  • 23
    • 39549106479 scopus 로고    scopus 로고
    • Ozone exposure in a mouse model induces airway hyperreactivity that requires the presenceofnatural killer T cells and IL-17
    • Pichavant M, Goya S, Meyer EH, Johnston RA, Kim HY, Matangkasombut P et al. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presenceofnatural killer T cells and IL-17. J Exp Med 2008; 205:385-393.
    • (2008) J Exp Med , vol.205 , pp. 385-393
    • Pichavant, M.1    Goya, S.2    Meyer, E.H.3    Johnston, R.A.4    Kim, H.Y.5    Matangkasombut, P.6
  • 24
    • 42649110747 scopus 로고    scopus 로고
    • Cutting edge: NKT cellsconstitutivelyexpressIL-receptorand RORgammatandrapidlyproduce IL-upon receptor ligation in an IL-6-independent fashion
    • Rachitskaya A, Hansen A, Horai R, Li Z, Villasmil R, Luger D et al. Cutting edge: NKT cellsconstitutivelyexpressIL-receptorand RORgammatandrapidlyproduce IL-upon receptor ligation in an IL-6-independent fashion. J Immunol 2008; 180: 5167-5171.
    • (2008) J Immunol , vol.180 , pp. 5167-5171
    • Rachitskaya, A.1    Hansen, A.2    Horai, R.3    Li, Z.4    Villasmil, R.5    Luger, D.6
  • 25
    • 49649123906 scopus 로고    scopus 로고
    • Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population
    • Coquet J, Chakravarti S, Kyparissoudis K, McNab F, Pitt L, McKenzie B et al. Diverse cytokine production by NKT cell subsets and identification of an IL-17-producing CD4-NK1.1- NKT cell population. Proc Natl Acad Sci USA 2008; 105: 11287-11292.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11287-11292
    • Coquet, J.1    Chakravarti, S.2    Kyparissoudis, K.3    McNab, F.4    Pitt, L.5    McKenzie, B.6
  • 27
    • 18944365630 scopus 로고    scopus 로고
    • Wagner MJ, Hussain S, Mehan M, Verdi JM, Delovitch TL. A defect in lineage fate decision during fet al thymic invariant NKT cell development may regulate susceptibility to type diabetes. J Immunol 2005; 174: 6764-6771.
    • Wagner MJ, Hussain S, Mehan M, Verdi JM, Delovitch TL. A defect in lineage fate decision during fet al thymic invariant NKT cell development may regulate susceptibility to type diabetes. J Immunol 2005; 174: 6764-6771.
  • 28
    • 0033523666 scopus 로고    scopus 로고
    • Adefectin interleukin 12- induced activation and interferon gamma secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-depen-dentdiabetes mellitus
    • Falcone M, Yeung B, Tucker L, Rodriguez E, Sarvetnick N. Adefectin interleukin 12- induced activation and interferon gamma secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic mechanisms for insulin-depen-dentdiabetes mellitus. J Exp Med 1999; 190:963-972.
    • (1999) J Exp Med , vol.190 , pp. 963-972
    • Falcone, M.1    Yeung, B.2    Tucker, L.3    Rodriguez, E.4    Sarvetnick, N.5
  • 29
    • 0032489860 scopus 로고    scopus 로고
    • Alpha/Beta-T cell receptor (TCR)(+)Cd4(-)Cd8(-) (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)- and/or IL-10
    • Hammond KJL, Poulton LD, Palmisano LJ, Silveira PA, Godfrey DI, Baxter AG. Alpha/Beta-T cell receptor (TCR)(+)Cd4(-)Cd8(-) (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)- and/or IL-10. JExp Med 1998; 187: 1047-1056.
    • (1998) JExp Med , vol.187 , pp. 1047-1056
    • Hammond, K.J.L.1    Poulton, L.D.2    Palmisano, L.J.3    Silveira, P.A.4    Godfrey, D.I.5    Baxter, A.G.6
  • 31
    • 0032538904 scopus 로고    scopus 로고
    • Overexpression of natural killer T cells protects V-alpha-14-J-alpha-2transgenic nonobese diabetic mice against diabetes
    • Lehuen A, Lantz O, Beaudoin L, LalouxV, Carnaud C, Bendelac A et al. Overexpression of natural killer T cells protects V-alpha-14-J-alpha-2transgenic nonobese diabetic mice against diabetes. J Exp Med 1998; 188: 1831-1839.
    • (1998) J Exp Med , vol.188 , pp. 1831-1839
    • Lehuen, A.1    Lantz, O.2    Beaudoin, L.3    Laloux, V.4    Carnaud, C.5    Bendelac, A.6
  • 32
    • 0036906618 scopus 로고    scopus 로고
    • NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells
    • Beaudoin L, Laloux V, Novak J, Lucas B, Lehuen A. NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic beta cells. Immunity 2002; 17: 725-736.
    • (2002) Immunity , vol.17 , pp. 725-736
    • Beaudoin, L.1    Laloux, V.2    Novak, J.3    Lucas, B.4    Lehuen, A.5
  • 33
    • 13544252802 scopus 로고    scopus 로고
    • Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts
    • Novak J, Beaudoin L, Griseri T, Lehuen A. Inhibition of T cell differentiation into effectors by NKT cells requires cell contacts. J Immunol 2005; 174: 1954-1961.
    • (2005) J Immunol , vol.174 , pp. 1954-1961
    • Novak, J.1    Beaudoin, L.2    Griseri, T.3    Lehuen, A.4
  • 34
    • 33846494233 scopus 로고    scopus 로고
    • Prevention of type diabetes by invariant NKT cells is independent of peripheral CD1d expression
    • Novak J, Beaudoin L, Park S, Griseri T, Teyton L, Bendelac A et al. Prevention of type diabetes by invariant NKT cells is independent of peripheral CD1d expression. J Immunol 2007; 178: 1332-1340.
    • (2007) J Immunol , vol.178 , pp. 1332-1340
    • Novak, J.1    Beaudoin, L.2    Park, S.3    Griseri, T.4    Teyton, L.5    Bendelac, A.6
  • 35
    • 0035923675 scopus 로고    scopus 로고
    • Activation ofCD1d-restricted T cells protects NOD micefrom developing diabetes byregulating dendritic cell subsets
    • Naumov YN, Bahjat KS, Gausling R, Abraham R, Exley MA, Koezuka Y et al. Activation ofCD1d-restricted T cells protects NOD micefrom developing diabetes byregulating dendritic cell subsets. Proc Natl Acad Sci USA 2001; 98: 13838-13843.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13838-13843
    • Naumov, Y.N.1    Bahjat, K.S.2    Gausling, R.3    Abraham, R.4    Exley, M.A.5    Koezuka, Y.6
  • 36
    • 0034786013 scopus 로고    scopus 로고
    • The natural killer T- cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice
    • Hong S, Wilson MT, Serizawa I, Wu L, Singh N, Naidenko OV et al. The natural killer T- cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med 2001; 7: 1052-1056.
    • (2001) Nat Med , vol.7 , pp. 1052-1056
    • Hong, S.1    Wilson, M.T.2    Serizawa, I.3    Wu, L.4    Singh, N.5    Naidenko, O.V.6
  • 37
    • 0034799397 scopus 로고    scopus 로고
    • Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type diabetes
    • Sharif S, Arreaza GA, Zucker P, Mi QS, Sondhi J, Naidenko OV et al. Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type diabetes. Nat Med 2001; 7: 1057-1062.
    • (2001) Nat Med , vol.7 , pp. 1057-1062
    • Sharif, S.1    Arreaza, G.A.2    Zucker, P.3    Mi, Q.S.4    Sondhi, J.5    Naidenko, O.V.6
  • 38
    • 19944431804 scopus 로고    scopus 로고
    • Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes
    • Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA et al. Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. J Immunol 2005; 174: 1196-1204.
    • (2005) J Immunol , vol.174 , pp. 1196-1204
    • Chen, Y.G.1    Choisy-Rossi, C.M.2    Holl, T.M.3    Chapman, H.D.4    Besra, G.S.5    Porcelli, S.A.6
  • 39
    • 9644259041 scopus 로고    scopus 로고
    • Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice
    • Mizuno M, Masumura M, Tomi C, Chiba A, Oki S, Yamamura T et al. Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice. J Autoimmun 2004; 23: 293-300.
    • (2004) J Autoimmun , vol.23 , pp. 293-300
    • Mizuno, M.1    Masumura, M.2    Tomi, C.3    Chiba, A.4    Oki, S.5    Yamamura, T.6
  • 40
    • 33846469009 scopus 로고    scopus 로고
    • Improved outcomes in NOD mice treated with a novel Thcytokine-biasing NKT cell activator
    • Forestier C, Takaki T, Molano A, Im JS, Baine I, Jerud ES et al. Improved outcomes in NOD mice treated with a novel Thcytokine-biasing NKT cell activator. J Immunol 2007; 178: 1415-1425.
    • (2007) J Immunol , vol.178 , pp. 1415-1425
    • Forestier, C.1    Takaki, T.2    Molano, A.3    Im, J.S.4    Baine, I.5    Jerud, E.S.6
  • 41
    • 0035817251 scopus 로고    scopus 로고
    • CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes
    • Wang B, Geng YB, Wang CR. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J Exp Med 2001; 194: 313-319.
    • (2001) J Exp Med , vol.194 , pp. 313-319
    • Wang, B.1    Geng, Y.B.2    Wang, C.R.3
  • 43
    • 2442542307 scopus 로고    scopus 로고
    • Up-regulation of CD1d expression restores the immunoregulatory function of NKT cells and prevents autoimmune diabetes in nonobese diabetic mice
    • Falcone M, Facciotti F, Ghidoli N, Monti P, Olivieri S, Zaccagnino L et al. Up-regulation of CD1d expression restores the immunoregulatory function of NKT cells and prevents autoimmune diabetes in nonobese diabetic mice. J Immunol 2004; 172: 5908-5916.
    • (2004) J Immunol , vol.172 , pp. 5908-5916
    • Falcone, M.1    Facciotti, F.2    Ghidoli, N.3    Monti, P.4    Olivieri, S.5    Zaccagnino, L.6
  • 44
    • 31144447382 scopus 로고    scopus 로고
    • NKT cells and IFN-{gamma} establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse
    • Cain JA, Smith JA, Ondr JK, Wang B, Katz JD. NKT cells and IFN-{gamma} establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol 2006; 176: 1645-1654.
    • (2006) J Immunol , vol.176 , pp. 1645-1654
    • Cain, J.A.1    Smith, J.A.2    Ondr, J.K.3    Wang, B.4    Katz, J.D.5
  • 46
    • 33745295229 scopus 로고    scopus 로고
    • Genetic and functional analysis of the Nktlocus using congenic NOD mice: Improved V{alpha}14- NKT cell performance but failure to protect against type diabetes
    • Rocha-Campos AC, Melki R, Zhu R, Deruytter N, Damotte D, Dy M et al. Genetic and functional analysis of the Nktlocus using congenic NOD mice: improved V{alpha}14- NKT cell performance but failure to protect against type diabetes. Diabetes 2006; 55: 1163-1170.
    • (2006) Diabetes , vol.55 , pp. 1163-1170
    • Rocha-Campos, A.C.1    Melki, R.2    Zhu, R.3    Deruytter, N.4    Damotte, D.5    Dy, M.6
  • 47
    • 51549118539 scopus 로고    scopus 로고
    • Congenic analysis of the NKT cell control gene Nktimplicates the peroxisomal protein Pxmp4
    • Fletcher J, Jordan M, Snelgrove S, Slattery R, Dufour F, Kyparissoudis K et al. Congenic analysis of the NKT cell control gene Nktimplicates the peroxisomal protein Pxmp4. J Immunol 2008; 181: 3400-3412.
    • (2008) J Immunol , vol.181 , pp. 3400-3412
    • Fletcher, J.1    Jordan, M.2    Snelgrove, S.3    Slattery, R.4    Dufour, F.5    Kyparissoudis, K.6
  • 48
    • 34548661992 scopus 로고    scopus 로고
    • Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice
    • Chen Y, Driver J, Silveira P, Serreze D. Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice. Immunogenetics 2007; 59: 705-712.
    • (2007) Immunogenetics , vol.59 , pp. 705-712
    • Chen, Y.1    Driver, J.2    Silveira, P.3    Serreze, D.4
  • 50
    • 0027272228 scopus 로고
    • Interleukin reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice
    • Rapoport M, Jaramillo A, Zipris D, Lazarus A, Serreze D, Leiter E et al. Interleukin reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. JExp Med 1993; 178:87-99.
    • (1993) JExp Med , vol.178 , pp. 87-99
    • Rapoport, M.1    Jaramillo, A.2    Zipris, D.3    Lazarus, A.4    Serreze, D.5    Leiter, E.6
  • 51
    • 0028222756 scopus 로고
    • Recombinant human IL-prevents the onset of diabetes in the nonobese diabetic mouse
    • Pennline K, Roque-Gaffney E, Monahan M. Recombinant human IL-prevents the onset of diabetes in the nonobese diabetic mouse. Clin Immunol Immunopathol 1994; 71: 169-175.
    • (1994) Clin Immunol Immunopathol , vol.71 , pp. 169-175
    • Pennline, K.1    Roque-Gaffney, E.2    Monahan, M.3
  • 52
    • 35348828497 scopus 로고    scopus 로고
    • Thor Thbalance regulated by interaction between dendritic cells and NKT cells
    • Onoe K, Yanagawa Y, Minami K, lijima N, Iwabuchi K. Thor Thbalance regulated by interaction between dendritic cells and NKT cells. Immunol Res 2007; 38: 319-332.
    • (2007) Immunol Res , vol.38 , pp. 319-332
    • Onoe, K.1    Yanagawa, Y.2    Minami, K.3    lijima, N.4    Iwabuchi, K.5
  • 53
    • 2342650811 scopus 로고    scopus 로고
    • Interleukin-but not interleukin-protects against spontaneous and recurrent type diabetes by activated CD1d- restricted invariant natural killer T-cells
    • Mi QS, Ly D, Zucker P, McGarry M, Delovitch TL. Interleukin-but not interleukin-protects against spontaneous and recurrent type diabetes by activated CD1d- restricted invariant natural killer T-cells. Diabetes 2004; 53: 1303-1310.
    • (2004) Diabetes , vol.53 , pp. 1303-1310
    • Mi, Q.S.1    Ly, D.2    Zucker, P.3    McGarry, M.4    Delovitch, T.L.5
  • 54
    • 0029948898 scopus 로고    scopus 로고
    • Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice
    • Hultgren B, Huang X, Dybdal N, Stewart T. Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice. Diabetes 1996; 45:812.
    • (1996) Diabetes , vol.45 , pp. 812
    • Hultgren, B.1    Huang, X.2    Dybdal, N.3    Stewart, T.4
  • 55
    • 0033669375 scopus 로고    scopus 로고
    • Interferon-gamma receptor signalling is dispensable in the development of autoimmune type diabetes in NOD mice
    • Serreze D, Post C, Chapman H, Johnson E, Lu B, Rothman P. Interferon-gamma receptor signalling is dispensable in the development of autoimmune type diabetes in NOD mice. Diabetes 2000; 49: 2007.
    • (2000) Diabetes , vol.49 , pp. 2007
    • Serreze, D.1    Post, C.2    Chapman, H.3    Johnson, E.4    Lu, B.5    Rothman, P.6
  • 56
    • 0036518287 scopus 로고    scopus 로고
    • Mouse and human dendritic cell subtypes
    • Shortman K, Liu Y. Mouse and human dendritic cell subtypes. Nat Rev immunol 2002; 2: 151-161.
    • (2002) Nat Rev immunol , vol.2 , pp. 151-161
    • Shortman, K.1    Liu, Y.2
  • 58
    • 33746644520 scopus 로고    scopus 로고
    • Glycolipid alpha-C- galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
    • Fujii S, Shimizu K, Hemmi H, Fukui M, Bonito AJ, Chen G et al. Glycolipid alpha-C- galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice. Proc Natl Acad Sci USA2006; 103:11252-11257.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11252-11257
    • Fujii, S.1    Shimizu, K.2    Hemmi, H.3    Fukui, M.4    Bonito, A.J.5    Chen, G.6
  • 59
    • 0347776209 scopus 로고    scopus 로고
    • Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
    • Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol 2003; 4:1230-1237.
    • (2003) Nat Immunol , vol.4 , pp. 1230-1237
    • Brigl, M.1    Bry, L.2    Kent, S.C.3    Gumperz, J.E.4    Brenner, M.B.5
  • 60
    • 0036091088 scopus 로고    scopus 로고
    • Altered dendritic cells (DC) might be responsible for regulatory Tcell imbalance and autoimmunityin nonobese diabetic (NOD) mice
    • BoudalyS, Morin J, Berthier R, Marche P, Boitard C. Altered dendritic cells (DC) might be responsible for regulatory Tcell imbalance and autoimmunityin nonobese diabetic (NOD) mice. Eur Cytokine Netw 2002; 13:29-37.
    • (2002) Eur Cytokine Netw , vol.13 , pp. 29-37
    • Boudaly, S.1    Morin, J.2    Berthier, R.3    Marche, P.4    Boitard, C.5
  • 61
    • 0034161702 scopus 로고    scopus 로고
    • Low CDexpression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-up-regulation
    • Dahlen E, Hedlund G, Dawe K. Low CDexpression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-up-regulation. J Immunol 2000; 164: 2444-2456.
    • (2000) J Immunol , vol.164 , pp. 2444-2456
    • Dahlen, E.1    Hedlund, G.2    Dawe, K.3
  • 62
    • 0035170432 scopus 로고    scopus 로고
    • Dendritic cell maturation is required for the cross- tolerization of CD8+T cells
    • Albert M, Jegathesan M, Darnell R. Dendritic cell maturation is required for the cross- tolerization of CD8+T cells. Nat Immunol 2001; 2: 1010-1017.
    • (2001) Nat Immunol , vol.2 , pp. 1010-1017
    • Albert, M.1    Jegathesan, M.2    Darnell, R.3
  • 64
    • 24744442779 scopus 로고    scopus 로고
    • Induction of regulatory properties in dendritic cells by V{alpha}NKT cells
    • Kojo S, Seino K, Harada M, Watarai H, Wakao H, Uchida T et al. Induction of regulatory properties in dendritic cells by V{alpha}NKT cells. J Immunol 2005; 175: 3648-3655.
    • (2005) J Immunol , vol.175 , pp. 3648-3655
    • Kojo, S.1    Seino, K.2    Harada, M.3    Watarai, H.4    Wakao, H.5    Uchida, T.6
  • 65
    • 29144487073 scopus 로고    scopus 로고
    • LiuR,LaCavaA,BaiXF,JeeY,PriceM,CampagnoloDIet al. Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia. J Immunol 2005; 175: 7898-7904.
    • LiuR,LaCavaA,BaiXF,JeeY,PriceM,CampagnoloDIet al. Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia. J Immunol 2005; 175: 7898-7904.
  • 66
    • 3142680192 scopus 로고    scopus 로고
    • Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells
    • Roelofs-Haarhuis K, Wu X, Gleichmann E. Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells. J Immunol 2004; 173: 1043-1050.
    • (2004) J Immunol , vol.173 , pp. 1043-1050
    • Roelofs-Haarhuis, K.1    Wu, X.2    Gleichmann, E.3
  • 67
    • 17444405627 scopus 로고    scopus 로고
    • Activated CD1d-restricted natural killer T cells secrete IL-2: Innate help for CD4(+)CD25(+) regulatory T cells?
    • Jiang S, Game DS, Davies D, Lombardi G, Lechler RI. Activated CD1d-restricted natural killer T cells secrete IL-2: innate help for CD4(+)CD25(+) regulatory T cells? Eur J Immunol 2005; 35: 1193-1200.
    • (2005) Eur J Immunol , vol.35 , pp. 1193-1200
    • Jiang, S.1    Game, D.S.2    Davies, D.3    Lombardi, G.4    Lechler, R.I.5
  • 68
    • 33748500822 scopus 로고    scopus 로고
    • Protection from typediabetes byinvariant NK T cells requires the activity of CD4+CD25+ regulatory T cells
    • LyD, Mi QS, Hussain S, Delovitch TL. Protection from typediabetes byinvariant NK T cells requires the activity of CD4+CD25+ regulatory T cells. J Immunol 2006; 177:3695-3704.
    • (2006) J Immunol , vol.177 , pp. 3695-3704
    • Ly, D.1    Mi, Q.S.2    Hussain, S.3    Delovitch, T.L.4
  • 69
    • 35348960243 scopus 로고    scopus 로고
    • Th17: The third member of the effector T cell trilogy
    • Bettelli E, Korn T, Kuchroo VK. Th17: the third member of the effector T cell trilogy. Curr Opin Immunol 2007; 19: 652-657.
    • (2007) Curr Opin Immunol , vol.19 , pp. 652-657
    • Bettelli, E.1    Korn, T.2    Kuchroo, V.K.3
  • 70
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the ILsystem in the induction of central nervous system autoimmune demyelination
    • Gran B, Zhang G, Yu S, Li J, Chen X, Ventura E et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the ILsystem in the induction of central nervous system autoimmune demyelination. J Immunol 2002; 169: 7104-7110.
    • (2002) J Immunol , vol.169 , pp. 7104-7110
    • Gran, B.1    Zhang, G.2    Yu, S.3    Li, J.4    Chen, X.5    Ventura, E.6
  • 71
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • Becher B, Durell B, Noelle R. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J ClinInvest 2002; 110: 493-497.
    • (2002) J ClinInvest , vol.110 , pp. 493-497
    • Becher, B.1    Durell, B.2    Noelle, R.3
  • 72
    • 0037442020 scopus 로고    scopus 로고
    • Induction of experimental autoimmune encephalomyelitis in IL-receptor-beta 2-deficient mice: IL-responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system
    • Zhang G, Gran B, Yu S, Li J, Siglienti I, Chen X et al. Induction of experimental autoimmune encephalomyelitis in IL-receptor-beta 2-deficient mice: IL-responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol 2003; 170: 2153-2160.
    • (2003) J Immunol , vol.170 , pp. 2153-2160
    • Zhang, G.1    Gran, B.2    Yu, S.3    Li, J.4    Siglienti, I.5    Chen, X.6
  • 73
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for thegeneration of pathogenic effector THand regulatoryT cells
    • Bettelli E, Carrier Y, Gao W, Korn T, Strom T, Oukka M et al. Reciprocal developmental pathways for thegeneration of pathogenic effector THand regulatoryT cells. Nature 2006; 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.5    Oukka, M.6
  • 74
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-rather than interleukin-is the critical cytokine for autoimmune inflammation of the brain
    • Cua D, Sherlock J, Chen Y, MurphyC, Joyce B, Seymour B et al. Interleukin-rather than interleukin-is the critical cytokine for autoimmune inflammation of the brain. Nature 2003; : 744-748.
    • (2003) Nature , pp. 744-748
    • Cua, D.1    Sherlock, J.2    Chen, Y.3    Murphy, C.4    Joyce, B.5    Seymour, B.6
  • 76
    • 33846456970 scopus 로고    scopus 로고
    • Tcell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    • Hirota K, Hashimoto M, Yoshitomi H, Tanaka S, Nomura T, Yamaguchi T et al. Tcell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. J Exp Med 2007; 204:41-47.
    • (2007) J Exp Med , vol.204 , pp. 41-47
    • Hirota, K.1    Hashimoto, M.2    Yoshitomi, H.3    Tanaka, S.4    Nomura, T.5    Yamaguchi, T.6
  • 77
    • 38749111445 scopus 로고    scopus 로고
    • Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-production
    • Jain R, Tartar DM, Gregg RK, Divekar RD, Bell JJ, Lee HH et al. Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-production. J Exp Med 2008; 205: 207-218.
    • (2008) J Exp Med , vol.205 , pp. 207-218
    • Jain, R.1    Tartar, D.M.2    Gregg, R.K.3    Divekar, R.D.4    Bell, J.J.5    Lee, H.H.6
  • 78
    • 40749118987 scopus 로고    scopus 로고
    • Sphingosine- 1-phosphate reduces CD4+ T-cell activation in type diabetes through regulation of hypoxia-inducible factor short isoform I.and CD69
    • Srinivasan S, Bolick DT, LukashevD, Lappas C, SitkovskyM, Lynch KR. Sphingosine- 1-phosphate reduces CD4+ T-cell activation in type diabetes through regulation of hypoxia-inducible factor short isoform I.and CD69. Diabetes 2008; 57: 484-493.
    • (2008) Diabetes , vol.57 , pp. 484-493
    • Srinivasan, S.1    Bolick, D.T.2    Lukashev, D.3    Lappas, C.4    Sitkovsky, M.5    Lynch, K.R.6
  • 80
    • 34547188748 scopus 로고    scopus 로고
    • Zhou L, IvanovI, Spolski R, Min R, ShenderovK, Egawa Tet al. IL-programs T(H)-cell differentiation by promoting sequential engagement of the IL-and IL-23pathways. Nat Immunol 2007; 8:967-974.
    • Zhou L, IvanovI, Spolski R, Min R, ShenderovK, Egawa Tet al. IL-programs T(H)-cell differentiation by promoting sequential engagement of the IL-and IL-23pathways. Nat Immunol 2007; 8:967-974.
  • 81
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-in the generation of inflammatory T cells
    • Nurieva R, Yang X, Martinez G, Zhang Y, Panopoulos A, Ma L et al. Essential autocrine regulation by IL-in the generation of inflammatory T cells. Nature 2007; 448: 480-483.
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1    Yang, X.2    Martinez, G.3    Zhang, Y.4    Panopoulos, A.5    Ma, L.6
  • 82
    • 34547232503 scopus 로고    scopus 로고
    • IL-initiates an alternative pathway to induce proinflammatory T(H)cells
    • Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom T et al. IL-initiates an alternative pathway to induce proinflammatory T(H)cells. Nature 2007; 448: 484-487.
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1    Bettelli, E.2    Gao, W.3    Awasthi, A.4    Jager, A.5    Strom, T.6
  • 83
    • 42649110747 scopus 로고    scopus 로고
    • Cutting edge: NKT cells constitutively express IL-receptor and RORgammat and rapidly produce IL-upon receptor ligation in an IL-6-independent fashion
    • Rachitskaya AV, Hansen AM, Horai R, Li Z, Villasmil R, Luger D et al. Cutting edge: NKT cells constitutively express IL-receptor and RORgammat and rapidly produce IL-upon receptor ligation in an IL-6-independent fashion. J Immunol 2008; 180: 5167-5171.
    • (2008) J Immunol , vol.180 , pp. 5167-5171
    • Rachitskaya, A.V.1    Hansen, A.M.2    Horai, R.3    Li, Z.4    Villasmil, R.5    Luger, D.6
  • 85
    • 0032495536 scopus 로고    scopus 로고
    • Extreme THbias of invariant V-alpha-24J-alpha-Q T cells in type diabetes
    • Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M et al. Extreme THbias of invariant V-alpha-24J-alpha-Q T cells in type diabetes. Nature 1998; 391:177-181.
    • (1998) Nature , vol.391 , pp. 177-181
    • Wilson, S.B.1    Kent, S.C.2    Patton, K.T.3    Orban, T.4    Jackson, R.A.5    Exley, M.6
  • 86
    • 0034691205 scopus 로고    scopus 로고
    • Multiple differences in gene expression in regulatory Valpha24Jalpha QT cells from identical twins discordant for type diabetes
    • Wilson S, Kent S, Horton H, Hill A, Bollyky P, Hafler D et al. Multiple differences in gene expression in regulatory Valpha24Jalpha QT cells from identical twins discordant for type diabetes. Proc Natl Acad Sci USA 2000; 97: 7411-7416.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 7411-7416
    • Wilson, S.1    Kent, S.2    Horton, H.3    Hill, A.4    Bollyky, P.5    Hafler, D.6
  • 90
    • 0035659927 scopus 로고    scopus 로고
    • Clinical application of NKT cell assays to the prediction of type diabetes
    • Poulton L, Baxter A. Clinical application of NKT cell assays to the prediction of type diabetes. Diab Met Res Rev 2001; 17: 429-435.
    • (2001) Diab Met Res Rev , vol.17 , pp. 429-435
    • Poulton, L.1    Baxter, A.2
  • 91
    • 33748745463 scopus 로고    scopus 로고
    • Phenotypic and genetic analyses of T-cell-mediated immunoregulation in patients with type diabetes
    • Tsutsumi Y, Jie X, Ihara K, Nomura S, Kanemitsu H, Takada H et al. Phenotypic and genetic analyses of T-cell-mediated immunoregulation in patients with type diabetes. Diab Med 2006; 23: 1145-1150.
    • (2006) Diab Med , vol.23 , pp. 1145-1150
    • Tsutsumi, Y.1    Jie, X.2    Ihara, K.3    Nomura, S.4    Kanemitsu, H.5    Takada, H.6
  • 92
    • 33847768664 scopus 로고    scopus 로고
    • Reduced CD4+ subset and Thbias of the human iNKT cells in type diabetes mellitus
    • Kis J, Engelmann P, Klara F, Richman G, Eck S, Lolley J et al. Reduced CD4+ subset and Thbias of the human iNKT cells in type diabetes mellitus. J Leukoc Biol 2006; 81: 654-662.
    • (2006) J Leukoc Biol , vol.81 , pp. 654-662
    • Kis, J.1    Engelmann, P.2    Klara, F.3    Richman, G.4    Eck, S.5    Lolley, J.6
  • 94
    • 0037018101 scopus 로고    scopus 로고
    • Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining
    • Gumperz JE, Miyake S, Yamamura T, Brenner MB. Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 2002; 195: 625-636.
    • (2002) J Exp Med , vol.195 , pp. 625-636
    • Gumperz, J.E.1    Miyake, S.2    Yamamura, T.3    Brenner, M.B.4
  • 95
    • 0037018108 scopus 로고    scopus 로고
    • Distinct functional lineages of human V alpha-natural killer T cells
    • Lee PT, Benlagha K, Teyton L, Bendelac A. Distinct functional lineages of human V alpha-natural killer T cells. J Exp Med 2002; 195:637-641.
    • (2002) J Exp Med , vol.195 , pp. 637-641
    • Lee, P.T.1    Benlagha, K.2    Teyton, L.3    Bendelac, A.4
  • 97
    • 3042720630 scopus 로고    scopus 로고
    • Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: Implications for human studies
    • Berzins SP, Kyparissoudis K, Pellicci DG, Hammond KJ, Sidobre S, Baxter A et al. Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies. Immunol Cell Biol 2004; 82:247-252.
    • (2004) Immunol Cell Biol , vol.82 , pp. 247-252
    • Berzins, S.P.1    Kyparissoudis, K.2    Pellicci, D.G.3    Hammond, K.J.4    Sidobre, S.5    Baxter, A.6
  • 98
    • 25444519199 scopus 로고    scopus 로고
    • Lossof IL-secretion from human type 1a diabetic pancreatic draining lymph node NKT cells
    • Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C et al. Lossof IL-secretion from human type 1a diabetic pancreatic draining lymph node NKT cells. J Immunol 2005; 175: 4458-4464.
    • (2005) J Immunol , vol.175 , pp. 4458-4464
    • Kent, S.C.1    Chen, Y.2    Clemmings, S.M.3    Viglietta, V.4    Kenyon, N.S.5    Ricordi, C.6
  • 99
    • 0042173087 scopus 로고    scopus 로고
    • Polarization of Valpha24+ Vbeta11+ natural killer T cells of healthy volunteers and cancer patients using alpha-galactosylceramide-loaded and environmentally instructed dendritic cells
    • van der Vliet HJ, Molling JW, Nishi N, Masterson AJ, Kolgen W, Porcelli SA et al. Polarization of Valpha24+ Vbeta11+ natural killer T cells of healthy volunteers and cancer patients using alpha-galactosylceramide-loaded and environmentally instructed dendritic cells. Cancer Res 2003; 63: 4101-4106.
    • (2003) Cancer Res , vol.63 , pp. 4101-4106
    • van der Vliet, H.J.1    Molling, J.W.2    Nishi, N.3    Masterson, A.J.4    Kolgen, W.5    Porcelli, S.A.6
  • 101
    • 0034254662 scopus 로고    scopus 로고
    • Linkage analysis of systemic lupus erythematosus induced in diabetes-prone nonobese diabetic mice by Mycobacterium bovis
    • Jordan M, Silveira P, Shepherd D, Chu C, Kinder S, Chen J et al. Linkage analysis of systemic lupus erythematosus induced in diabetes-prone nonobese diabetic mice by Mycobacterium bovis. J Immunol 2000; 165: 1673-1684.
    • (2000) J Immunol , vol.165 , pp. 1673-1684
    • Jordan, M.1    Silveira, P.2    Shepherd, D.3    Chu, C.4    Kinder, S.5    Chen, J.6
  • 102
    • 0035949582 scopus 로고    scopus 로고
    • Transgenic rescue implicates B2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice
    • Hamilton-Williams E, Serreze D, CHarlton B, Johnson E, Marron M, Mullbacher A et al. Transgenic rescue implicates B2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proc Natl Acad Sci USA 2001; 98: 11533-11538.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11533-11538
    • Hamilton-Williams, E.1    Serreze, D.2    CHarlton, B.3    Johnson, E.4    Marron, M.5    Mullbacher, A.6
  • 103
    • 15444374149 scopus 로고    scopus 로고
    • Defective NKT cell development in mice and humans lacking the adapter SAP, the X- linked lymphoproliferative syndrome gene product
    • Pasquier B, Yin L, Fondaneche MC, Relouzat F, Bloch-Queyrat C, Lambert N et al. Defective NKT cell development in mice and humans lacking the adapter SAP, the X- linked lymphoproliferative syndrome gene product. J Exp Med 2005; 201:695-701.
    • (2005) J Exp Med , vol.201 , pp. 695-701
    • Pasquier, B.1    Yin, L.2    Fondaneche, M.C.3    Relouzat, F.4    Bloch-Queyrat, C.5    Lambert, N.6
  • 104
    • 20144387328 scopus 로고    scopus 로고
    • Regulation of NKT cell development by SAP, the protein defective in XLP
    • Nichols KE, Hom J, Gong SY, Ganguly A, Ma CS, Cannons JL et al. Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med 2005; 11:340-345.
    • (2005) Nat Med , vol.11 , pp. 340-345
    • Nichols, K.E.1    Hom, J.2    Gong, S.Y.3    Ganguly, A.4    Ma, C.S.5    Cannons, J.L.6
  • 105
    • 14844339362 scopus 로고    scopus 로고
    • Cutting edge: Signaling lymphocytic activation molecule-associated protein controls NKT cell functions
    • Chung B, Aoukaty A, Dutz J, Terhorst C, Tan R. Cutting edge: signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J Immunol 2005; 174: 3153-3157.
    • (2005) J Immunol , vol.174 , pp. 3153-3157
    • Chung, B.1    Aoukaty, A.2    Dutz, J.3    Terhorst, C.4    Tan, R.5
  • 106
    • 0032853934 scopus 로고    scopus 로고
    • Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice
    • Eberl G, Lowin-Kropf B, MacDonald HR. Cutting edge: NKT cell development is selectively impaired in Fyn-deficient mice. J Immunol 1999; 163: 4091-4094.
    • (1999) J Immunol , vol.163 , pp. 4091-4094
    • Eberl, G.1    Lowin-Kropf, B.2    MacDonald, H.R.3
  • 107
    • 0032723181 scopus 로고    scopus 로고
    • The Src family tyrosine kinase Fyn regulates natural killer T cell development
    • Gadue P, Morton N, Stein PL. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med 1999; 190: 1189-1196.
    • (1999) J Exp Med , vol.190 , pp. 1189-1196
    • Gadue, P.1    Morton, N.2    Stein, P.L.3
  • 108
    • 36049012716 scopus 로고    scopus 로고
    • Homotypic interactions mediated by Slamfand Slamfreceptors control NKT cell lineage development
    • Griewank K, Borowski C, Rietdijk S, Wang N, Julien A, Wei DG et al. Homotypic interactions mediated by Slamfand Slamfreceptors control NKT cell lineage development. Immunity 2007; 27: 751-762.
    • (2007) Immunity , vol.27 , pp. 751-762
    • Griewank, K.1    Borowski, C.2    Rietdijk, S.3    Wang, N.4    Julien, A.5    Wei, D.G.6
  • 109
    • 49049097166 scopus 로고    scopus 로고
    • Impaired SLAM- SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKTcells in nonobese diabetic mice
    • Baev D, Caielli S, Ronchi F, Coccia M, Facciotto F, Nichols K et al. Impaired SLAM- SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKTcells in nonobese diabetic mice. J Immunol 2008; 181:869-877.
    • (2008) J Immunol , vol.181 , pp. 869-877
    • Baev, D.1    Caielli, S.2    Ronchi, F.3    Coccia, M.4    Facciotto, F.5    Nichols, K.6
  • 110
    • 0031914643 scopus 로고    scopus 로고
    • Subcongenic analysis of the Iddlocus in NOD/Lt mice: Evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin
    • Serreze D, Bridgett M, Chapman H, Chen E, Richard S, Leiter E. Subcongenic analysis of the Iddlocus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin. J Immunol 1998; 160: 1472-1478.
    • (1998) J Immunol , vol.160 , pp. 1472-1478
    • Serreze, D.1    Bridgett, M.2    Chapman, H.3    Chen, E.4    Richard, S.5    Leiter, E.6
  • 111
    • 1442334370 scopus 로고    scopus 로고
    • The peroxisome: Orchestrating important developmental decisions from inside the cell
    • Titorenko V, Rachiubinski R. The peroxisome: orchestrating important developmental decisions from inside the cell. J Cell Biol 2004; 164: 641-645.
    • (2004) J Cell Biol , vol.164 , pp. 641-645
    • Titorenko, V.1    Rachiubinski, R.2
  • 112
    • 0034611003 scopus 로고    scopus 로고
    • PEXbinds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis
    • Sacksteder K, Jones J, South S, Li X, Liu Y, Gould S. PEXbinds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J Cell Biol 2000; 148: 931-944.
    • (2000) J Cell Biol , vol.148 , pp. 931-944
    • Sacksteder, K.1    Jones, J.2    South, S.3    Li, X.4    Liu, Y.5    Gould, S.6
  • 113
    • 17344372511 scopus 로고    scopus 로고
    • A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus
    • Concannon P, Gogolin-Ewens K, Hinds D, Wapelhorst B, Morrison V, Stirling B et al. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nat Genet 1998; 19: 292-296.
    • (1998) Nat Genet , vol.19 , pp. 292-296
    • Concannon, P.1    Gogolin-Ewens, K.2    Hinds, D.3    Wapelhorst, B.4    Morrison, V.5    Stirling, B.6
  • 115
    • 0942276861 scopus 로고    scopus 로고
    • Therapeutic activation of V{alpha}24+V{beta}11+NKT cellsin human subjectsresultsin highlycoordinated secondaryactivation of acquired and innate immunity
    • Nieda M, Okai M, Tazbirkova A, Lin H, Yamaura A, IdeK et al. Therapeutic activation of V{alpha}24+V{beta}11+NKT cellsin human subjectsresultsin highlycoordinated secondaryactivation of acquired and innate immunity. Blood 2004; 103: 383-389.
    • (2004) Blood , vol.103 , pp. 383-389
    • Nieda, M.1    Okai, M.2    Tazbirkova, A.3    Lin, H.4    Yamaura, A.5    IdeK6
  • 116
    • 0036896332 scopus 로고    scopus 로고
    • AphaseI studyof the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors
    • GiacconeG, PuntCJA, Ando Y, RuijterR, Nishi N, PetersM et al. AphaseI studyof the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors. Clin Cancer Res 2002; 8: 3702-3709.
    • (2002) Clin Cancer Res , vol.8 , pp. 3702-3709
    • Giaccone, G.1    Punt, C.J.A.2    Ando, Y.3    Ruijter, R.4    Nishi, N.5    Peters, M.6
  • 117
    • 20144388064 scopus 로고    scopus 로고
    • Aphase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lungcancer
    • IshikawaA, Motohashi S, IshikawaE, FuchidaH, HigashinoK, Otsuji M et al. Aphase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lungcancer. Clin Cancer Res 2005; 11:1910-1917.
    • (2005) Clin Cancer Res , vol.11 , pp. 1910-1917
    • Ishikawa, A.1    Motohashi, S.2    Ishikawa, E.3    Fuchida, H.4    Higashino, K.5    Otsuji, M.6
  • 118
    • 1242351228 scopus 로고    scopus 로고
    • Expansion of human Valpha24(+)NKT cells byrepeated stimulation with KRN7000
    • RogersPR, MatsumotoA, NaidenkoO, KronenbergM, MikayamaT, KatoS. Expansion of human Valpha24(+)NKT cells byrepeated stimulation with KRN7000. J Immunol Methods 2004; 285:197-214.
    • (2004) J Immunol Methods , vol.285 , pp. 197-214
    • RogersPR1    MatsumotoA2    NaidenkoO3    KronenbergM4    MikayamaT5    KatoS6
  • 119
    • 0035166455 scopus 로고    scopus 로고
    • Potent expansion of human natural killer T cells using alpha- galactosylceramide (KRN7000)-loaded monocyte-derived dendritic cells, cultured in the presence of IL-and IL-15
    • van der Vliet HJJ, Nishi N, Koezuka Y, von Blomberg BME, van den Eertwegh AJM, Porcelli SA et al. Potent expansion of human natural killer T cells using alpha- galactosylceramide (KRN7000)-loaded monocyte-derived dendritic cells, cultured in the presence of IL-and IL-15. J Immunol Methods 2001; 247:61-72.
    • (2001) J Immunol Methods , vol.247 , pp. 61-72
    • van der Vliet, H.J.J.1    Nishi, N.2    Koezuka, Y.3    von Blomberg, B.M.E.4    van den Eertwegh, A.J.M.5    Porcelli, S.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.